2020
Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers
Tollenaar L, Slaghekke F, Lewi L, Ville Y, Lanna M, Weingertner A, Ryan G, Arévalo S, Khalil A, Brock C, Klaritsch P, Hecher K, Gardener G, Bevilacqua E, Kostyukov K, Bahtiyar M, Kilby M, Tiblad E, Oepkes D, Lopriore E, Middeldorp J, Haak M, Klumper F, Akkermans J, Delagrange H, Pandya V, Faiola S, Favre R, Hobson S, Rodo C, Thilaganathan B, Papanna R, Greimel P, de Sousa M, Carlin A, Gladkova K, Copel J. Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers. Ultrasound In Obstetrics And Gynecology 2020, 56: 378-387. PMID: 32291846, PMCID: PMC7497010, DOI: 10.1002/uog.22042.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequenceFetal therapy centersMonochorionic twin pregnanciesPost-laser twin anemia-polycythemia sequenceExpectant management groupSevere neonatal morbidityIntrauterine transfusionExpectant managementPerinatal mortalitySelective feticideTwin pregnanciesLaser surgeryNeonatal morbidityDelivery groupIUT groupDiagnosis of TAPSMiddle cerebral artery peak systolic velocityFetal middle cerebral artery peak systolic velocityBirth intervalLaser surgery groupProlongation of pregnancyTherapy CenterPeak systolic velocityLarge international cohortMedian diagnosis
1997
Increase of fetal hematocrit decreases the middle cerebral artery peak systolic velocity in pregnancies complicated by rhesus alloimmunization
Mari G, Rahman F, Olofsson P, Ozcan T, Copel J. Increase of fetal hematocrit decreases the middle cerebral artery peak systolic velocity in pregnancies complicated by rhesus alloimmunization. The Journal Of Maternal-Fetal Medicine 1997, 6: 206-208. PMID: 9260116, DOI: 10.1002/(sici)1520-6661(199707/08)6:4<206::aid-mfm3>3.0.co;2-n.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal hematocritTime of studyIntrauterine transfusionRed blood cellsFetal anemiaRhesus alloimmunizationGestational ageRh alloimmunizationDoppler ultrasoundBlood cellsHematocritAlloimmunizationPregnancyT-testP-valueDoppler measurementsStatistical comparisonTransfusionAnemiaDiagnosisIncrease of Fetal Hematocrit Decreases the Middle Cerebral Artery Peak Systolic Velocity in Pregnancies Complicated by Rhesus Alloimmunization
Mari G, Rahman F, Olofsson P, Ozcan T, Copel J. Increase of Fetal Hematocrit Decreases the Middle Cerebral Artery Peak Systolic Velocity in Pregnancies Complicated by Rhesus Alloimmunization. The Journal Of Maternal-Fetal Medicine 1997, 6: 206-208. DOI: 10.3109/14767059709161986.Peer-Reviewed Original ResearchMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal hematocritTime of studyIntrauterine transfusionRed blood cellsFetal anemiaRhesus alloimmunizationGestational ageRh alloimmunizationDoppler ultrasoundBlood cellsHematocritAlloimmunizationPregnancyT-testP-valueDoppler measurementsStatistical comparisonTransfusionAnemiaDiagnosis
1995
Management of the Rh-Sensitizeo Mother
Gollin Y, Copel J. Management of the Rh-Sensitizeo Mother. Clinics In Perinatology 1995, 22: 545-559. PMID: 8521681, DOI: 10.1016/s0095-5108(18)30268-9.ChaptersConceptsRh immune globulinManagement of complicationsRh D typingEarly referralIntrauterine transfusionImmune globulinRh isoimmunizationTertiary centerAnemic fetusesNeonatal careFetal bloodInvasive techniquesLung maturityPrompt identificationD typingClinical situationsOptimal managementFetusesMothersTransfusionComplicationsIsoimmunizationNeonatesNeonatologistsPerinatologists
1993
Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization.
Saade G, Moise K, Copel J, Belfort M, Carpenter R. Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization. Obstetrics And Gynecology 1993, 82: 987-91. PMID: 8233277.Peer-Reviewed Original ResearchConceptsRed cell alloimmunizationFetal platelet countPlatelet countNonhydropic fetusesBilirubin levelsReticulocyte countMaternal red cell alloimmunizationLow platelet countStudent's t-testFetal plateletsHydropic fetusesIntrauterine transfusionFetal anemiaGestational ageInitial transfusionAnemic fetusesHematopoietic stem cellsFetusesAlloimmunizationThrombocytopeniaTransfusionRegression analysisT-testAnemiaHydropic
1989
Fetal cardiac output in the isoimmunized pregnancy: A pulsed Doppler-echocardiographic study of patients undergoing intravascular intrauterine transfusion
Copel J, Grannum P, Green J, Belanger K, Hanna N, Jaffe C, Hobbins J, Kleinman C. Fetal cardiac output in the isoimmunized pregnancy: A pulsed Doppler-echocardiographic study of patients undergoing intravascular intrauterine transfusion. American Journal Of Obstetrics And Gynecology 1989, 161: 361-365. PMID: 2504042, DOI: 10.1016/0002-9378(89)90520-6.Peer-Reviewed Original ResearchConceptsCardiac outputAnemic fetusesIsoimmunized pregnanciesCombined ventricular outputDoppler echocardiographic studyFetal cardiac outputHigh output stateHigh cardiac outputIntravascular intrauterine transfusionSevere isoimmunizationCardiac indexIntrauterine transfusionIntravascular transfusionWeeks' gestationVentricular outputDoppler assessmentAge-specific normsControl fetusesHydrops fetalisControl groupMechanisms of developmentFetusesUnaffected fetusesTransfusionPregnancy
1988
Pulsed Doppler flow-velocity waveforms before and after intrauterine intravascular transfusion for severe erythroblastosis fetalis
Copel J, Grannum P, Belanger K, Green J, Hobbins J. Pulsed Doppler flow-velocity waveforms before and after intrauterine intravascular transfusion for severe erythroblastosis fetalis. American Journal Of Obstetrics And Gynecology 1988, 158: 768-774. PMID: 2966585, DOI: 10.1016/0002-9378(88)90070-1.Peer-Reviewed Original ResearchConceptsLate transfusionDoppler flow velocity waveformsIntrauterine intravascular transfusionFlow velocity waveformsSevere erythroblastosis fetalisFirst transfusionIntrauterine transfusionSubsequent transfusionsErythroblastosis fetalisIntravascular transfusionIsoimmunized pregnanciesDoppler studiesMaternal circulationDoppler ultrasoundTransfusionNormal fetusesHematocrit changesLack of changeHematocritDoppler parametersFetusesRapid volumeHydropsPregnancyFetalisThe reversal of hydrops fetalis by intravascular intrauterine transfusion in severe isoimmune fetal anemia
Grannum P, Copel J, Moya F, Scioscia A, Robert J, Winn H, Coster B, Burdine C, Hobbins J. The reversal of hydrops fetalis by intravascular intrauterine transfusion in severe isoimmune fetal anemia. American Journal Of Obstetrics And Gynecology 1988, 158: 914-919. PMID: 3284364, DOI: 10.1016/0002-9378(88)90094-4.Peer-Reviewed Original ResearchConceptsGm/dlIntrauterine intravascular transfusionIntravascular transfusionHematocrit levelsSurvival rateSevere respiratory distress syndromeReversal of hydropsOverall survival rateRespiratory distress syndromeTime of referralIntravascular intrauterine transfusionSevere erythroblastosis fetalisTotal proteinIntrauterine transfusionNeonatal morbidityErythroblastosis fetalisHydropic fetusesDistress syndromeFetal anemiaExchange transfusionNeonatal deathIntraperitoneal transfusionSevere erythroblastosisNewborn periodIntravascular treatment