2019
Depression and all‐cause mortality risk in HIV‐infected and HIV‐uninfected US veterans: a cohort study
So‐Armah K, Gupta S, Kundu S, Stewart J, Goulet J, Butt A, Sico J, Marconi, Crystal S, Rodriguez‐Barradas M, Budoff M, Gibert C, Chang C, Bedimo R, Freiberg. Depression and all‐cause mortality risk in HIV‐infected and HIV‐uninfected US veterans: a cohort study. HIV Medicine 2019, 20: 317-329. PMID: 30924577, PMCID: PMC6459698, DOI: 10.1111/hiv.12726.Peer-Reviewed Original ResearchConceptsHIV infectionMajor depressive disorderHIV statusDepressive symptomsMedian followCause mortalityDepressive disorderMortality riskVeterans Aging Cohort Study (VACS) dataDeath rateMajor depressive disorder diagnosisFirst clinic visitCause mortality riskPHQ-9 scoresNinth Revision codesPatient Health QuestionnaireDepressive disorder diagnosisPHQ-9 dataCohort study dataContribution of depressionDepression definitionsClinic visitsCohort studyComorbid conditionsEligible participants
2015
Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients
Weisberg DF, Gordon KS, Barry DT, Becker WC, Crystal S, Edelman EJ, Gaither J, Gordon AJ, Goulet J, Kerns RD, Moore BA, Tate J, Justice AC, Fiellin DA. Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 69: 223-233. PMID: 26009831, PMCID: PMC4446730, DOI: 10.1097/qai.0000000000000591.Peer-Reviewed Original ResearchConceptsLong-term opioidsMorphine equivalent daily doseOpioid receiptRisk of deathLong-term prescriptionUninfected patientsOpioid dosesAntiretroviral therapyHazard ratioDaily dosePropensity scoreHigher opioid dosesCause mortalityHIV statusAvailable patientsMortality riskOpioidsHIVPatientsProspective analysisMortalityBenzodiazepinesDosesDeathRisk
2011
When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study.
Cain L, Logan R, Robins J, Sterne J, Sabin C, Bansi L, Justice A, Goulet J, van Sighem A, de Wolf F, Bucher H, von Wyl V, Esteve A, Casabona J, del Amo J, Moreno S, Seng R, Meyer L, Perez-Hoyos S, Muga R, Lodi S, Lanoy E, Costagliola D, Hernan M. When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. Annals Of Internal Medicine 2011, 154: 509-15. PMID: 21502648, PMCID: PMC3610527, DOI: 10.7326/0003-4819-154-8-201104190-00001.Peer-Reviewed Original ResearchConceptsCD4 cell countCombined end pointHazard ratioCell countCells/LAntiretroviral therapyCells/L.CD4 cell count thresholdBaseline CD4 cell countEnd pointVeterans Health Administration systemInitiation of cARTThreshold CD4 countCorresponding hazard ratiosMortality hazard ratioAIDS-free survivalProspective observational dataHIV-CAUSAL CollaborationMost clinical guidelinesHealth Administration systemUse of CD4Marginal structural modelsCell count thresholdCART initiationDynamic marginal structural modelsAlcohol consumption and depressive symptoms over time: A longitudinal study of patients with and without HIV infection
Sullivan LE, Goulet JL, Justice AC, Fiellin DA. Alcohol consumption and depressive symptoms over time: A longitudinal study of patients with and without HIV infection. Drug And Alcohol Dependence 2011, 117: 158-163. PMID: 21345624, PMCID: PMC3113463, DOI: 10.1016/j.drugalcdep.2011.01.014.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyNon-hazardous drinkersDepressive symptomsAlcohol consumptionAlcohol abuseCohort studyHIV infectionBinge drinkersBinge drinkingNon-hazardous drinkingAging Cohort StudyPatient Health QuestionnaireUnhealthy alcohol consumptionCurrent alcohol useHIV statusHealth QuestionnaireTime-varying outcomeHazardous drinkersPatientsHIVHazardous drinkingAlcohol dependenceSymptomsAlcohol useSimilar alterations
2010
Time to Depression Treatment in Primary Care Among HIV-infected and Uninfected Veterans
Hooshyar D, Goulet J, Chwastiak L, Crystal S, Gibert C, Mattocks K, Rimland D, Rodriguez-Barradas M, Justice AC, for the VACS Project Team. Time to Depression Treatment in Primary Care Among HIV-infected and Uninfected Veterans. Journal Of General Internal Medicine 2010, 25: 656-662. PMID: 20405335, PMCID: PMC2881956, DOI: 10.1007/s11606-010-1323-z.Peer-Reviewed Original ResearchConceptsPHQ-9 assessmentMental health visitsDepressed HIVUninfected patientsHIV serostatusDepression treatmentPrimary careDepression severityHealth visitsInclusion criteriaPatient Health Questionnaire scoresUntreated depressive symptomsPrimary care treatmentKaplan-Meier curvesPHQ-9 scoresGeneral medicine clinicProportional hazards methodsStudy inclusion criteriaMajority of depressionsAntidepressant receiptBackgroundMultiple factorsUninfected veteransPatient characteristicsProspective cohortTotal cohortPsychosocial distress in patients treated for cancer pain: a prospective observational study.
O'Mahony S, Goulet JL, Payne R. Psychosocial distress in patients treated for cancer pain: a prospective observational study. Journal Of Opioid Management 2010, 6: 211-22. PMID: 20642250, DOI: 10.5055/jom.2010.0019.Peer-Reviewed Original Research
2009
Erectile Dysfunction Drug Receipt, Risky Sexual Behavior and Sexually Transmitted Diseases in HIV-infected and HIV-uninfected Men
Cook RL, McGinnis KA, Samet JH, Fiellin DA, Rodriquez-Barradas M, Kraemer KL, Gibert CL, Braithwaite RS, Goulet JL, Mattocks K, Crystal S, Gordon AJ, Oursler KK, Justice AC. Erectile Dysfunction Drug Receipt, Risky Sexual Behavior and Sexually Transmitted Diseases in HIV-infected and HIV-uninfected Men. Journal Of General Internal Medicine 2009, 25: 115-121. PMID: 19921112, PMCID: PMC2837496, DOI: 10.1007/s11606-009-1164-9.Peer-Reviewed Original ResearchConceptsErectile dysfunction drugsRisky sexual behaviorSexual behaviorUnprotected sexAdministrative pharmacy dataMinority of HIVUnknown HIV statusSample of HIVPercent of menElectronic medical recordsThousand seven hundredUninfected menHIV statusOutpatient clinicMore prescriptionsPharmacy dataMedical recordsCharacteristics of menPrevention interventionsCare providersDrug receiptHIVMultivariate analysisSubstance usersSeven hundredThe Association Between the Receipt of Lipid Lowering Therapy and HIV Status Among Veterans Who Met NCEP/ATP III Criteria for the Receipt of Lipid Lowering Medication
Freiberg MS, Leaf DA, Goulet JL, Goetz MB, Oursler KK, Gibert CL, Rodriguez-Barradas MC, Butt AA, Justice AC. The Association Between the Receipt of Lipid Lowering Therapy and HIV Status Among Veterans Who Met NCEP/ATP III Criteria for the Receipt of Lipid Lowering Medication. Journal Of General Internal Medicine 2009, 24: 334-340. PMID: 19127386, PMCID: PMC2642578, DOI: 10.1007/s11606-008-0891-7.Peer-Reviewed Original ResearchConceptsNCEP/ATP III criteriaATP III criteriaHIV viral loadViral loadAdult Treatment Panel guidelinesHigher HIV viral loadFive-site studyLipid lowering medicationsVeterans Aging CohortHIV infection statusLipid-Lowering TherapyProspective observational cohortCross-sectional analysisHIV-HCVLowering therapiesModifiable mediatorsObservational cohortResultsThe prevalenceHIV infectionHIV statusPharmacy dataCardiovascular diseasePanel guidelinesMAIN OUTCOMELow prevalence
2008
Impact of Pneumococcal Vaccination on the Incidence of Pneumonia by HIV Infection Status among Patients Enrolled in the Veterans Aging Cohort 5-Site Study
Rodriguez-Barradas MC, Goulet J, Brown S, Goetz MB, Rimland D, Simberkoff MS, Crothers K, Justice AC. Impact of Pneumococcal Vaccination on the Incidence of Pneumonia by HIV Infection Status among Patients Enrolled in the Veterans Aging Cohort 5-Site Study. Clinical Infectious Diseases 2008, 46: 1093-1100. PMID: 18444830, PMCID: PMC3115628, DOI: 10.1086/529201.Peer-Reviewed Original ResearchConceptsPneumococcal polysaccharide vaccineVeterans Aging CohortPPV vaccinationIncidence of pneumoniaAging CohortCox proportional hazards regression methodsLow CD4 cell countsProportional hazards regression methodsCD4 cell countHIV infection statusRisk of pneumoniaLower hemoglobin levelsBenefits of vaccinationHuman immunodeficiency virusOngoing prospective studyElectronic medical recordsPneumococcal vaccinationPneumonia eventsUnvaccinated patientsCurrent smokingPneumococcal diseasePolysaccharide vaccineVaccination statusHIV infectionRetrospective reviewQuantifying the Decrement in Utility from Perceived Side Effects of Combination Antiretroviral Therapies in Patients with HIV
Braithwaite RS, Goulet J, Kudel I, Tsevat J, Justice AC. Quantifying the Decrement in Utility from Perceived Side Effects of Combination Antiretroviral Therapies in Patients with HIV. Value In Health 2008, 11: 975-979. PMID: 18225989, PMCID: PMC3121315, DOI: 10.1111/j.1524-4733.2007.00315.x.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyBothersome symptomsSF-6D utilitiesAntiretroviral therapyCD4 countSide effectsVeterans Aging Cohort StudyAging Cohort StudySF-12 scoresAfrican American raceHazardous alcohol consumptionQuality of lifeRecent drug useCART initiationMild anginaCohort studyMultivariable analysisCigarette smokingUnivariate analysisAmerican raceAlcohol consumptionDrug useUtility decrementsPatientsClinical decision
2006
Veterans Aging Cohort Study (VACS)
Justice AC, Dombrowski E, Conigliaro J, Fultz SL, Gibson D, Madenwald T, Goulet J, Simberkoff M, Butt AA, Rimland D, Rodriguez-Barradas MC, Gibert CL, Oursler KA, Brown S, Leaf DA, Goetz MB, Bryant K. Veterans Aging Cohort Study (VACS). Medical Care 2006, 44: s13-s24. PMID: 16849964, PMCID: PMC3049942, DOI: 10.1097/01.mlr.0000223741.02074.66.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyHuman immunodeficiency virusAging Cohort StudyCohort studyHIV infectionGeneral medical clinicMultisite observational studyElectronic medical record systemRace/ethnicityUninfected patientsBaseline characteristicsMedical record systemTarget enrollmentImmunodeficiency virusObservational studyNational VAMedical clinicsInfectious diseasesDisease controlTelephone interviewsStudy designAlcohol useEnrollment targetsCareVeterans