2023
PET Quantification and Kinetic Analysis
Carson R, Naganawa M, Gallezot J. PET Quantification and Kinetic Analysis. 2023, 183-194. DOI: 10.1007/978-3-031-35098-6_12.ChaptersMathematical modelingLinearized techniqueModel simplificationApplication of modelingApplication of modelsModeling techniquesModel validationTracer kinetic modeling techniquesEquationsInput functionModelingKinetic modeling techniquesModelCompartment modelOptimizationAlternative approachAccurate measurementApplicationsSimplificationDynamics
2021
Generation of parametric Ki images for FDG PET using two 5‐min scans
Wu J, Liu H, Ye Q, Gallezot J, Naganawa M, Miao T, Lu Y, Chen M, Esserman DA, Kyriakides TC, Carson RE, Liu C. Generation of parametric Ki images for FDG PET using two 5‐min scans. Medical Physics 2021, 48: 5219-5231. PMID: 34287939, DOI: 10.1002/mp.15113.Peer-Reviewed Original ResearchConceptsPopulation-based input functionDynamic FDG-PET scansFDG-PET scansFDG-PETSUV changesPET scansClinical practiceSolid lung nodulesClinical usefulnessLate scansBone marrowRegion of interestLung nodulesInput functionScansPatlak analysisKi imagesMin/T-testCorrelation coefficientTumorsSubjectsNodulesDynamic imagingPET
2020
Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET
Naganawa M, Gallezot JD, Shah V, Mulnix T, Young C, Dias M, Chen MK, Smith AM, Carson RE. Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET. EJNMMI Physics 2020, 7: 67. PMID: 33226522, PMCID: PMC7683759, DOI: 10.1186/s40658-020-00330-x.Peer-Reviewed Original ResearchPopulation-based input functionImage-derived input functionInitial distribution volumeArterial input functionInjected doseBlood samplingWhole bodyStandard arterial input functionInitial plasma concentrationsArterial blood samplingOncological patientsPlasma concentrationsGold standard methodDistribution volumePET studiesPET imagingSubject heightInput functionAUCAUC valuesTest-retest dataClinical environmentLater time windowKi valuesImaging