2021
Jazf1 acts as a regulator of insulin‐producing β‐cell differentiation in induced pluripotent stem cells and glucose homeostasis in mice
Park S, Kwon W, Park S, Jeong J, Kim D, Jang S, Kim S, Sung Y, Kim M, Choi S, Ryoo Z. Jazf1 acts as a regulator of insulin‐producing β‐cell differentiation in induced pluripotent stem cells and glucose homeostasis in mice. The FEBS Journal 2021, 288: 4412-4427. PMID: 33555104, DOI: 10.1111/febs.15751.Peer-Reviewed Original Research
2020
Enhanced Meningeal Lymphatic Drainage Ameliorates Neuroinflammation and Hepatic Encephalopathy in Cirrhotic Rats
Hsu SJ, Zhang C, Jeong J, Lee SI, McConnell M, Utsumi T, Iwakiri Y. Enhanced Meningeal Lymphatic Drainage Ameliorates Neuroinflammation and Hepatic Encephalopathy in Cirrhotic Rats. Gastroenterology 2020, 160: 1315-1329.e13. PMID: 33227282, PMCID: PMC7956141, DOI: 10.1053/j.gastro.2020.11.036.Peer-Reviewed Original ResearchConceptsMeningeal lymphatic drainageLymphatic drainageMicroglia activationMotor functionBile duct ligation modelTumor necrosis factor αSerious neurologic complicationsMeningeal lymphatic systemNecrosis factor αDuct ligation modelNew therapeutic strategiesBrain inflammationNeurologic complicationsHepatic encephalopathyLiver cirrhosisLymph nodesRotarod testMotor dysfunctionCirrhotic ratsInterleukin-1βLigation modelInterferon γProinflammatory genesCisterna magnaTherapeutic strategies
2019
Lin28a expression protects against streptozotocin‐induced β‐cell destruction and prevents diabetes in mice
Sung Y, Jeong J, Kang R, Choi M, Park S, Kwon W, Lee J, Jang S, Park S, Kim S, Yi J, Choi S, Lee M, Liu K, Dong Z, Ryoo Z, Kim M. Lin28a expression protects against streptozotocin‐induced β‐cell destruction and prevents diabetes in mice. Cell Biochemistry And Function 2019, 37: 139-147. PMID: 30883865, DOI: 10.1002/cbf.3376.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCell growthΒ-cell destructionImportant regulatorLet-7 biogenesisLet-7 regulationPancreatic β-cell functionRole of Lin28Family of miRNAsRecent genome-wide association studiesΒ-cell functionPancreatic β-cell deathCell cycle progressionCell cycle regulatorsLin28/letΒ-cell deathOverexpression of Lin28aMiRNA biogenesisSkeletal myogenesisPrecise modulationEmbryonic developmentLin28a/Pancreatic β-cellsCycle regulatorsCycle progression
2016
Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1
Jang W, Jeong J, Kim S, Kang M, Sung Y, Choi M, Park S, Kim M, Kim S, Ryoo Z. Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1. Applied Physiology Nutrition And Metabolism 2016, 41: 640-648. PMID: 27218680, DOI: 10.1139/apnm-2015-0369.Peer-Reviewed Original ResearchConceptsHigh-fat dietSAA1 levelsAmyloid depositionTg miceMetabolic disturbancesTransgenic miceHepatic serum amyloid A1Elevated levelsImpaired glucose toleranceLow-grade inflammationLocal cytokine expressionChronic inflammatory conditionsHigh-fat diet challengeSerum amyloid A1Acute phase response proteinsMajor precursor proteinCrohn's diseaseGlucose toleranceCytokine expressionInflammatory conditionsMetabolic parametersSerum amyloidMetabolic disordersAmyloid depositsDiet challenge