2023
Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gains
2017
Neuroeconomic approach to trauma related psychopathology: A version to ambiguous losses in PTSD
Harpaz-Rotem I, Jia R, Ruderman L, Pietrzak R, Levy I. Neuroeconomic approach to trauma related psychopathology: A version to ambiguous losses in PTSD. European Psychiatry 2017, 41: s358. DOI: 10.1016/j.eurpsy.2017.02.349.Peer-Reviewed Original ResearchAnxious arousal symptomsArousal symptomsAmbiguity attitudesCombat exposureTrauma-related symptomatologyTrauma-Related PsychopathologyTrauma-related symptomsWhole-brain analysisBehavioral economics techniquesSeverity of PTSDDisclosure of interestNeuroeconomic approachNeural underpinningsTraditional diagnostic categoriesSpecific brain areasCombat veteransRelated psychopathologyAmbiguous optionBehavioral outcomesFMRI dataBrain analysisPTSDLoss domainAmbiguous lossBrain areas