2024
Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage
Rivier C, Renedo D, Marini S, Magid‐Bernstein J, de Havenon A, Rosand J, Hanley D, Ziai W, Mayer S, Woo D, Sansing L, Sheth K, Anderson C, Falcone G. Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage. Annals Of Neurology 2024 PMID: 39499118, DOI: 10.1002/ana.27123.Peer-Reviewed Original ResearchRisk of hematoma expansionHighest risk of hematoma expansionRisk of poor outcomesIntracerebral hemorrhageHematoma expansionHigh riskMale sexPoor outcomeOutcome of spontaneous intracerebral hemorrhageClinical characteristics of patientsStudies of intracerebral hemorrhageNon-traumatic intracerebral hemorrhageIndividual patient data meta-analysisPatient data meta-analysisSpontaneous intracerebral hemorrhageSingle-center studyIntracerebral hemorrhage patientsHigh risk of expansionCharacteristics of patientsIntracerebral hemorrhage severityPoor functional outcomeRandomized clinical trialsData meta-analysisHemorrhage volumeClinical characteristicsOral Health as a Risk Factor for Spontaneous Intracerebral Hemorrhage: A Mendelian Randomization Analysis (S34.001)
Rivier C, Clocchiatti-Tuozzo S, Huo S, Renedo D, Hawkes M, Sunmonu N, Sheth K, Falcone G. Oral Health as a Risk Factor for Spontaneous Intracerebral Hemorrhage: A Mendelian Randomization Analysis (S34.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204999.Peer-Reviewed Original ResearchSpontaneous intracerebral hemorrhageMendelian randomization analysisOral healthIntracerebral hemorrhageRandomization analysisRisk factorsHemorrhageCerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
Rivier C, Kamel H, Sheth K, Iadecola C, Gupta A, de Leon M, Ross E, Falcone G, Murthy S. Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage. JAMA Neurology 2024, 81: 163-169. PMID: 38147345, PMCID: PMC10751656, DOI: 10.1001/jamaneurol.2023.4918.Peer-Reviewed Original ResearchCerebral amyloid angiopathyMultivariable logistic regression analysisSubdural hemorrhageLogistic regression analysisIntracerebral hemorrhageIntracranial hemorrhageUK Biobank cohortAmyloid angiopathyMean ageUS cohortRisk factorsHigher oddsDiagnosis of CAAPopulation-based cohort studyBiobank cohortClinical Modification diagnosis codesCAA-related intracerebral hemorrhageCox proportional hazards modelRegression analysisAntithrombotic medication useIndependent risk factorCox regression analysisMultivariable logistic regressionNovel risk factorsSpontaneous intracerebral hemorrhage
2021
Chronic Kidney Disease is Associated with Higher Risk and Worse Outcome after Spontaneous Intracerebral Hemorrhage (2729)
Leasure A, Vanent K, Acosta J, Woo D, Murthy S, Kamel H, Cohen J, Townsend R, Petersen N, Sansing L, Gill T, Sheth K, Falcone G. Chronic Kidney Disease is Associated with Higher Risk and Worse Outcome after Spontaneous Intracerebral Hemorrhage (2729). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2729.Peer-Reviewed Original ResearchChronic kidney diseaseSpontaneous intracerebral hemorrhageIntracerebral hemorrhageKidney diseaseWorse outcomesHigh riskHemorrhageDiseaseAssociation of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage
Leasure AC, Kuohn LR, Vanent KN, Bevers MB, Kimberly WT, Steiner T, Mayer SA, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage. Stroke 2021, 52: 1733-1740. PMID: 33682454, PMCID: PMC8085132, DOI: 10.1161/strokeaha.120.032888.Peer-Reviewed Original ResearchConceptsIL-6 levelsPerihematomal edema volumeIntracerebral hemorrhageIL-6Edema volumeFunctional outcomeICH locationICH volumeTreatment groupsSerum IL-6 levelsBaseline ICHAcute brain injuryLarge intracerebral hemorrhageSerum IL-6Predictors of outcomeSpontaneous intracerebral hemorrhageRankin ScalePoor outcomeProinflammatory cytokinesTrial populationBrain injurySecondary analysisStrong associationFast trialsOutcomesAdmission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage
Acosta JN, Leasure AC, Kuohn LR, Both CP, Petersen NH, Sansing LH, Matouk CC, Testai F, Langefeld CD, Woo D, Kamel H, Murthy SB, Qureshi A, Mayer SA, Sheth KN, Falcone GJ. Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage. Critical Care Medicine 2021, 49: 828-837. PMID: 33591003, PMCID: PMC8611893, DOI: 10.1097/ccm.0000000000004891.Peer-Reviewed Original ResearchConceptsAdmission hemoglobin levelsHemoglobin levelsNontraumatic intracerebral hemorrhageIntracerebral hemorrhageHematoma volumePoor outcomeHematoma expansionIntracerebral hemorrhage patientsPredictors of outcomeSpontaneous intracerebral hemorrhageIndividual patient dataHigher hemoglobin levelsAdmission hematoma volumeExposure of interestDose-response analysisAdmission hemoglobinRankin ScalePrimary outcomeHemorrhage patientsFunctional outcomeRepeat CTClinical trialsObservational studyHemorrhage sizeBetter outcomesIntracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset
Witsch J, Falcone GJ, Leasure AC, Matouk C, Endres M, Sansing L, Woo D, Sheth KN. Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset. Neurocritical Care 2021, 35: 418-427. PMID: 33479920, PMCID: PMC8578176, DOI: 10.1007/s12028-020-01180-2.Peer-Reviewed Original ResearchConceptsLoss of consciousnessIntraventricular hemorrhageIntracerebral hemorrhageSymptom onsetICH onsetUnfavorable outcomeAdmission Glasgow Coma ScoreAdmission systolic blood pressureOnset of ICHGlasgow Coma ScoreSystolic blood pressureSpontaneous intracerebral hemorrhageAdmission serum glucoseThousand seven hundredVolumetric CT measurementsBackgroundIn patientsComa ScoreBlood pressureMedical chartsICH volumeMental statusSerum glucoseICH casesInclusion criteriaPatients
2020
Statin treatment and cerebral microbleeds: A systematic review and meta-analysis
Katsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, Boasquevisque D, Falcone GJ, Sheth KN, Romero JR, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A, Initiative T. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis. Journal Of The Neurological Sciences 2020, 420: 117224. PMID: 33183779, DOI: 10.1016/j.jns.2020.117224.Peer-Reviewed Original ResearchConceptsCMB presenceStatin useCurrent statin useStatin treatmentRandomized-controlled clinical trialSpontaneous intracerebral hemorrhageRandom-effects modelCMB prevalenceIschemic strokeHemorrhagic strokeAdjusted analysisCerebral microbleedsIntracerebral hemorrhageRandomized trialsUnadjusted analysesClinical trialsEligible studiesAncillary studiesObservational studyPooled estimatesGeneral populationSystematic reviewUnadjusted probabilitySystematic searchCross-sectional data
2019
Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage
Dhar R, Falcone GJ, Chen Y, Hamzehloo A, Kirsch EP, Noche RB, Roth K, Acosta J, Ruiz A, Phuah CL, Woo D, Gill TM, Sheth KN, Lee JM. Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage. Stroke 2019, 51: 648-651. PMID: 31805845, PMCID: PMC6993878, DOI: 10.1161/strokeaha.119.027657.Peer-Reviewed Original ResearchConceptsSupratentorial intracerebral hemorrhagePerihematomal edemaIntracerebral hemorrhagePHE volumeResults Two hundred twentyIntracerebral Hemorrhage (ERICH) studyMechanism of injuryIntracerebral hemorrhage patientsSpontaneous intracerebral hemorrhageLarge cohort studyComputed tomography scanSecondary outcomesCohort studyPrimary outcomeHemorrhage patientsSecondary injuryTomography scanHundred twentyMedian volumeLarge cohortHemorrhagePatientsQuantification of hemorrhageFirst cohortDisease biologyAntiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes
Murthy SB, Biffi A, Falcone GJ, Sansing LH, Torres Lopez V, Navi BB, Roh DJ, Mandava P, Hanley DF, Ziai WC, Kamel H, Rosand J, Sheth KN, Butcher K, Davis S, Gregson B, Lees K, Lyden P, Mayer S, Muir K, Steiner T. Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes. Stroke 2019, 50: 3057-3063. PMID: 31895618, PMCID: PMC6941441, DOI: 10.1161/strokeaha.119.025972.Peer-Reviewed Original ResearchConceptsAntiplatelet therapyIntracerebral hemorrhageFunctional outcomeHematoma locationCause mortalityMajor disabilityVirtual International Stroke Trials Archive databaseCox proportional regression analysisConclusions Antiplatelet therapyRecurrent intracerebral hemorrhageProportional regression analysisPoor functional outcomeRandomized clinical trialsSpontaneous intracerebral hemorrhagePaucity of dataAntiplatelet medicationsStroke RegistryThromboembolic riskHazard ratioMulticenter cohortPrimary outcomeMedian timeICH patientsClinical trialsMeta-analyzed dataAssociation of Intensive Blood Pressure Reduction With Risk of Hematoma Expansion in Patients With Deep Intracerebral Hemorrhage
Leasure AC, Qureshi AI, Murthy SB, Kamel H, Goldstein JN, Woo D, Ziai WC, Hanley DF, Salman R, Matouk CC, Sansing LH, Sheth KN, Falcone GJ. Association of Intensive Blood Pressure Reduction With Risk of Hematoma Expansion in Patients With Deep Intracerebral Hemorrhage. JAMA Neurology 2019, 76: 949-955. PMID: 31081862, PMCID: PMC6515816, DOI: 10.1001/jamaneurol.2019.1141.Peer-Reviewed Original ResearchIntensive Blood Pressure ReductionDeep intracerebral hemorrhageBlood pressure reductionIntracerebral hemorrhageHematoma expansionStandard treatmentIntensive treatmentPressure reductionMAIN OUTCOMEModified Rankin scale score distributionIntensive blood pressure treatmentRankin Scale score distributionBasal ganglia intracerebral hemorrhageThalamic intracerebral hemorrhageBasal ganglia hemorrhageBlood pressure treatmentStandard treatment groupModified Rankin ScaleRankin Scale scorePrimary intracerebral hemorrhageAcute care settingStrong risk factorSpontaneous intracerebral hemorrhageDeep brain nucleiAntihypertensive treatmentIntensive Blood Pressure Reduction and Perihematomal Edema Expansion in Deep Intracerebral Hemorrhage
Leasure AC, Qureshi AI, Murthy SB, Kamel H, Goldstein JN, Walsh KB, Woo D, Shi FD, Huttner HB, Ziai WC, Hanley DF, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Intensive Blood Pressure Reduction and Perihematomal Edema Expansion in Deep Intracerebral Hemorrhage. Stroke 2019, 50: 2016-2022. PMID: 31272326, PMCID: PMC6646091, DOI: 10.1161/strokeaha.119.024838.Peer-Reviewed Original ResearchConceptsDeep intracerebral hemorrhageIntensive BP reductionBasal ganglia intracerebral hemorrhageBlood pressure reductionIntracerebral hemorrhageBP reductionPoor outcomeATACH-2Intensive Blood Pressure ReductionPressure reductionPerihematomal edema expansionSecondary brain injurySupratentorial intracerebral hemorrhagePerihematomal edema volumeSpontaneous intracerebral hemorrhageRelevant end pointsDeep locationBaseline characteristicsEdema volumeBasal gangliaBrain injuryClinical trialsTomography scanEdema expansionTreatment groupsIdentification and Validation of Hematoma Volume Cutoffs in Spontaneous, Supratentorial Deep Intracerebral Hemorrhage
Leasure AC, Sheth KN, Comeau M, Aldridge C, Worrall BB, Vashkevich A, Rosand J, Langefeld C, Moomaw CJ, Woo D, Falcone GJ. Identification and Validation of Hematoma Volume Cutoffs in Spontaneous, Supratentorial Deep Intracerebral Hemorrhage. Stroke 2019, 50: 2044-2049. PMID: 31238829, PMCID: PMC6646054, DOI: 10.1161/strokeaha.118.023851.Peer-Reviewed Original ResearchConceptsDeep intracerebral hemorrhageBasal ganglia intracerebral hemorrhageIntracerebral hemorrhagePoor outcomeValidation cohortC-statisticVolume cutoffDeep ICH patientsMultivariable outcome modelsThalamic intracerebral hemorrhageSpontaneous intracerebral hemorrhageATACH-2 trialClinical trial designCharacteristic curve analysisDeep brain nucleiEffects of interventionsATACH-2Complete neuroimagingICH variesICH patientsICH volumeBasal gangliaCandidate therapiesInclusion criteriaOutcome data
2018
Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage
Ormseth CH, Falcone GJ, Jasak SD, Mampre DM, Leasure AC, Miyares LC, Hwang DY, James ML, Testai FD, Becker KJ, Tirschwell DL, Langefeld CD, Woo D, Sheth KN. Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage. Neurocritical Care 2018, 29: 419-425. PMID: 29949003, PMCID: PMC6286261, DOI: 10.1007/s12028-018-0554-4.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageHematoma volumeAdmission Glasgow Coma ScaleEthnic/Racial VariationsNon-traumatic intracerebral hemorrhageIntracerebral Hemorrhage (ERICH) studyProspective cohort studyGlasgow Coma ScaleIntensive care unitWithdrawal of careSpontaneous intracerebral hemorrhageSimilar mortality ratesLogistic regression analysisRace/ethnicity modifiesRace/ethnicityCMO patientsHospital mortalityCohort studyRankin ScaleWhite patientsComa ScaleBlack patientsCare unitEndotracheal intubationICH patientsPlasma IL-6 Levels are Independently Associated with Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral Hemorrhage (P4.296)
Leasure A, Steinschneider A, Falcone G, Gilmore E, Sansing L, Sheth K. Plasma IL-6 Levels are Independently Associated with Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral Hemorrhage (P4.296). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.296.Peer-Reviewed Original ResearchPlasma IL-6 levelsIL-6 levelsSpontaneous intracerebral hemorrhageIntracerebral hemorrhageSecondary injuryFunctional outcomeHemorrhageInjury
2014
CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery
Brouwers HB, Raffeld MR, van Nieuwenhuizen KM, Falcone GJ, Ayres AM, McNamara KA, Schwab K, Romero JM, Velthuis BK, Viswanathan A, Greenberg SM, Ogilvy CS, van der Zwan A, Rinkel GJ, Goldstein JN, Klijn CJ, Rosand J. CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery. Neurology 2014, 83: 883-889. PMID: 25098540, PMCID: PMC4153853, DOI: 10.1212/wnl.0000000000000747.Peer-Reviewed Original ResearchConceptsPostoperative rebleedingIntracerebral hemorrhageSpontaneous intracerebral hemorrhageSpot signActive bleedingHematoma evacuationIntraoperative bleedingCase fatalityICH volumeCT angiography spot signBrainstem ICHOnly independent markerSurgical hematoma evacuationSpontaneous ICH patientsMultivariable logistic regressionConsecutive spontaneous ICH patientsFuture surgical trialsSpot sign presenceCTA spot signAntiplatelet usePostoperative bleedingResidual hematomaICH patientsFemale sexSurgical trials