2024
Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk
Marini S, Kimball T, Mayerhofer E, Tack R, Senff J, Prapiadou S, Rivier C, Duskin J, Kourkoulis C, Falcone G, Yechoor N, Tanzi R, Rosand J, Singh S, Parodi L, Anderson C. Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk. Neurology 2024, 103: e210014. PMID: 39504504, DOI: 10.1212/wnl.0000000000210014.Peer-Reviewed Original ResearchConceptsLate-life depressionGenetic riskDementia riskUK Biobank (UKBEffects of healthy lifestylesHealth-related behaviorsGenetic predispositionElevated genetic riskProspective cohort studyHazard of strokeCox proportional hazards modelsAge-related brain diseasesLifestyle behaviorsCare scoresUKB participantsProportional hazards modelHealthy lifestyleIncidence of strokeMultivariate Cox proportional hazards modelPolygenic scoresTargeted interventionsLifestyle adjustmentsAggregate risk estimatesRisk estimatesCohort studyThe predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1373797. PMID: 39109366, PMCID: PMC11301016, DOI: 10.3389/fpsyt.2024.1373797.Peer-Reviewed Original ResearchIncident late-life depressionLate-life depressionBrain health outcomesCare scoresHealth outcomesHealthy lifestyle choicesOutcome of dementiaUK Biobank cohortRisk factorsComposite outcomeCox proportional hazards modelsCare providersBiobank cohortProportional hazards modelIncident casesMultivariate Cox proportional hazards modelRisk of strokeLifestyle changesClinical careLifestyle choicesDementiaBrain healthFuture depressionBaseline evaluationComplete dataAPOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart diseaseRadiomic Features of Acute Cerebral Hemorrhage on Non-Contrast CT Associated with Patient Survival
Zaman S, Dierksen F, Knapp A, Haider S, Karam G, Qureshi A, Falcone G, Sheth K, Payabvash S. Radiomic Features of Acute Cerebral Hemorrhage on Non-Contrast CT Associated with Patient Survival. Diagnostics 2024, 14: 944. PMID: 38732358, PMCID: PMC11083693, DOI: 10.3390/diagnostics14090944.Peer-Reviewed Original ResearchInternational Normalized RatioArea under the curveNational Institutes of Health Stroke ScaleIntracerebral hemorrhageRadiomic featuresAntihypertensive Treatment of Acute Cerebral Hemorrhage IINon-contrast head CT scanBaseline International Normalized RatioAssociated with worse survival outcomesAcute intracerebral hemorrhageSupratentorial intracerebral hemorrhageWorse survival outcomesKaplan-Meier analysisHead CT scanCox proportional hazards modelsPredictors of mortalityAcute cerebral hemorrhageReceiver Operating Characteristic (ROC) analysisFirst-order energyHigher mortality riskProportional hazards modelHealth Stroke ScaleCT radiomicsHematoma expansionPost-ICH
2016
Cortical superficial siderosis predicts early recurrent lobar hemorrhage
Roongpiboonsopit D, Charidimou A, William CM, Lauer A, Falcone GJ, Martinez-Ramirez S, Biffi A, Ayres A, Vashkevich A, Awosika OO, Rosand J, Gurol ME, Silverman SB, Greenberg SM, Viswanathan A. Cortical superficial siderosis predicts early recurrent lobar hemorrhage. Neurology 2016, 87: 1863-1870. PMID: 27694268, PMCID: PMC5100711, DOI: 10.1212/wnl.0000000000003281.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisConvexity subarachnoid hemorrhageCerebral amyloid angiopathyRecurrent ICHSuperficial siderosisAcute convexity subarachnoid hemorrhageDisseminated cortical superficial siderosisSingle-center cohort studyBaseline ICH volumeRecurrent lobar hemorrhageProportional hazards modelWhite matter hyperintensitiesIntracerebral hemorrhage recurrenceLobar hemorrhageLobar ICHSymptomatic ICHBoston criteriaConsecutive survivorsCohort studyAmyloid angiopathyHemorrhage recurrenceIndependent predictorsUnivariable analysisCerebral microbleedsIndex event
2014
Dietary Fiber and Amyotrophic Lateral Sclerosis: Results From 5 Large Cohort Studies
Fondell E, O'Reilly É, Fitzgerald KC, Falcone GJ, Kolonel LN, Park Y, McCullough ML, Ascherio A. Dietary Fiber and Amyotrophic Lateral Sclerosis: Results From 5 Large Cohort Studies. American Journal Of Epidemiology 2014, 179: 1442-1449. PMID: 24816788, PMCID: PMC4051879, DOI: 10.1093/aje/kwu089.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisCohort studyALS riskFiber intakeLateral sclerosisCause of ALSLarge prospective cohort studyRisk of ALSProspective cohort studyHigh fiber intakeMedian survival timeCase-control studyLarge cohort studyProportional hazards modelCohort-specific estimatesRandom-effects modelInflammatory markersProspective studyHighest quintileALS casesDietary intakeCereal fiberSurvival timeLower riskHazards model
2013
Magnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studies
Fondell E, O’Reilly É, Fitzgerald KC, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Magnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studies. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2013, 14: 356-361. PMID: 23777266, PMCID: PMC3743429, DOI: 10.3109/21678421.2013.803577.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisMagnesium intakeALS riskCohort studyLateral sclerosisCases of ALSLarge prospective cohort studyProspective cohort studyDietary magnesium intakeLow magnesium intakeCase-control studyLarge cohort studyProportional hazards modelCohort-specific estimatesRandom-effects modelProspective studyHighest quintileDietary intakeProtective effectHazards modelIntakeMagnesium absorptionSclerosisHeavy metal exposureRisk
2012
Premorbid body mass index and risk of amyotrophic lateral sclerosis
O'Reilly ÉJ, Wang H, Weisskopf MG, Fitzgerald KC, Falcone G, McCullough ML, Thun M, Park Y, Kolonel LN, Ascherio A. Premorbid body mass index and risk of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2012, 14: 205-211. PMID: 23134505, PMCID: PMC3615420, DOI: 10.3109/21678421.2012.735240.Peer-Reviewed Original ResearchConceptsBody mass indexHealthy body mass indexPremorbid body mass indexALS ratesMass indexCohort-specific Cox proportional hazard modelsLower premorbid Body Mass IndexLower body mass indexCox proportional hazards modelAmyotrophic lateral sclerosis riskProportional hazards modelAmyotrophic lateral sclerosisRandom-effects modelOngoing cohortUnhealthy weightLateral sclerosisHazards modelUndiagnosed diseaseCurrent weightWeight lossObeseALSAssociationMalesFemalesNon-steroidal anti-inflammatory drugs and amyotrophic lateral sclerosis: Results from five prospective cohort studies
Fondell E, O'Reilly ÉJ, Fitzgerald KC, Falcone GJ, McCullough ML, Thun MJ, Park Y, Kolonel LN, Ascherio A. Non-steroidal anti-inflammatory drugs and amyotrophic lateral sclerosis: Results from five prospective cohort studies. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2012, 13: 573-579. PMID: 22871075, PMCID: PMC3474335, DOI: 10.3109/17482968.2012.703209.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drugsProspective cohort studyNSAID useALS riskAnti-inflammatory drugsCohort studyNon-aspirin NSAID useNon-aspirin NSAID usersAmyotrophic lateral sclerosis (ALS) pathologyLarge prospective cohort studyProportional hazards modelAmyotrophic lateral sclerosisCohort-specific estimatesRandom-effects modelAspirin useNSAID usersProspective dataRelative riskPathological studiesLateral sclerosisHazards modelRiskEffects modelDrugsOverall effect