2005
On the bright right side
Wackers F. On the bright right side. Journal Of Nuclear Cardiology 2005, 12: 378-380. PMID: 16084425, DOI: 10.1016/j.nuclcard.2005.05.005.Peer-Reviewed Original Research
2003
Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction
Navare SM, Wackers FJ, Liu YH. Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction. European Journal Of Nuclear Medicine And Molecular Imaging 2003, 30: 1330-1337. PMID: 12838373, DOI: 10.1007/s00259-003-1231-0.Peer-Reviewed Original ResearchConceptsSingle photon emission tomographyEnd-diastolic volumeEnd-systolic volumePerfusion defectsEjection fractionMyocardial perfusionSPET imagesLV volumesLeft ventricular end-diastolic volumeVentricular end-diastolic volumeSmaller end-systolic volumeLarger end-diastolic volumeSignificant perfusion defectsMyocardial perfusion defectsRadiotracer doseHigher LVEFVentricular functionLow doseVentricular volumeEmission tomographyLV parametersDoseLVEFECG gatingPatients
2000
Effect of left ventricular volume on results of coronary artery bypass grafting
Kim R, Ugurlu B, Tereb D, Wackers F, Tellides G, Elefteriades J. Effect of left ventricular volume on results of coronary artery bypass grafting. The American Journal Of Cardiology 2000, 86: 1261-1264. PMID: 11090805, DOI: 10.1016/s0002-9149(00)01216-9.Peer-Reviewed Original ResearchConceptsCoronary artery bypassArtery bypassSignificant left ventricular dilationLeft ventricular dilationLV chamber sizeLV ejection fractionMedium-term survivalSurgical revascularizationAngina symptomsEjection fractionIschemic cardiomyopathyLV dilationVentricular dilationVentricular sizeVentricular volumePatientsSignificant reductionBypassChamber sizeDilationRevascularizationCardiomyopathySymptoms
1999
Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging
Shen M, Liu Y, Sinusas A, Fetterman R, Bruni W, Drozhinin O, Zaret B, Wackers F. Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging. Journal Of Nuclear Cardiology 1999, 6: 583-595. PMID: 10608585, DOI: 10.1016/s1071-3581(99)90095-8.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationDiastoleElectrocardiographyHeart VentriclesHumansImage Processing, Computer-AssistedModels, CardiovascularMyocardial InfarctionObserver VariationPhantoms, ImagingPilot ProjectsRadiopharmaceuticalsReproducibility of ResultsSoftwareSystoleTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonVentricular Function, LeftVentricular RemodelingVentriculography, First-PassConceptsPrior myocardial infarctionRegional wall thickeningNormal subjectsMyocardial infarctionWall thickeningNormal wall thickeningPilot studyRegional left ventricular functionLeft ventricular functionAbnormal wall thickeningPercent count increaseECG-gated SPECT imagesSingle photon emissionSPECT imagesCardiac cycleLeft ventricular wallReproducibility of interpretationRegional left ventricular wallPrior infarctionCoronary diseaseVentricular functionValidation studyInfarct areaNormal rangeAnatomic areasEjection fraction by radionuclide ventriculography and contrast left ventriculogram A tale of two techniques
Ureña P, Lamas G, Mitchell G, Flaker G, Smith S, Wackers F, McEwan P, Pfeffer M, investigators F. Ejection fraction by radionuclide ventriculography and contrast left ventriculogram A tale of two techniques. Journal Of The American College Of Cardiology 1999, 33: 180-185. PMID: 9935027, DOI: 10.1016/s0735-1097(98)00533-6.Peer-Reviewed Original ResearchConceptsRadionuclide ventriculographyEjection fractionCardiovascular eventsEvent ratesMyocardial infarctionPostinfarct patientsIndependent predictorsRisk stratificationAssess prognosisClinical eventsVentricular performanceClinical impressionPatientsMultivariate analysisPrognosisVentriculographyTercileEF measurementsBest predictorPredictorsComparative abilityCatheterizationInfarctionVentriculograms
1993
Frequency and significance of right ventricular dysfunction during inferior wall left ventricular myocardial infarction treated with thrombolytic therapy (results from the Thrombolysis in Myocardial Infarction [TIMI] II trial)
Berger P, Ruocco N, Ryan T, Jacobs A, Zaret B, Wackers F, Frederick M, Faxon D, Group R. Frequency and significance of right ventricular dysfunction during inferior wall left ventricular myocardial infarction treated with thrombolytic therapy (results from the Thrombolysis in Myocardial Infarction [TIMI] II trial). The American Journal Of Cardiology 1993, 71: 1148-1152. PMID: 8097614, DOI: 10.1016/0002-9149(93)90637-r.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngioplasty, Balloon, CoronaryCombined Modality TherapyConstriction, PathologicCoronary VesselsFemaleHeart DiseasesHeart VentriclesHumansMaleMiddle AgedMyocardial InfarctionRadionuclide VentriculographyThrombolytic TherapyTissue Plasminogen ActivatorVentricular Function, LeftVentricular Function, RightConceptsRV wall motion abnormalitiesRight ventricular dysfunctionRV dysfunctionVentricular myocardial infarctionWall motion abnormalitiesVentricular dysfunctionThrombolytic therapyRadionuclide ventriculographyMyocardial infarctionMotion abnormalitiesInferior wallLower mean left ventricular ejection fractionMean left ventricular ejection fractionLeft ventricular ejection fractionBaseline clinical characteristicsInfarct-related arteryMyocardial Infarction (TIMI) II trialVentricular ejection fractionEquilibrium radionuclide ventriculographyHospital complicationsMultivessel diseaseII trialClinical characteristicsHospital dischargeEjection fraction
1990
Silent left ventricular dysfunction during routine activity after thrombolytic Therapy for acute myocardial infarction
Kayden D, Wackers F, Zaret B. Silent left ventricular dysfunction during routine activity after thrombolytic Therapy for acute myocardial infarction. Journal Of The American College Of Cardiology 1990, 15: 1500-1507. PMID: 2345230, DOI: 10.1016/0735-1097(90)92817-l.Peer-Reviewed Original ResearchConceptsTransient left ventricular dysfunctionLeft ventricular dysfunctionSilent left ventricular dysfunctionVentricular dysfunctionMyocardial infarctionCardiac eventsHospital dischargeEjection fractionThrombolytic therapySubmaximal supine bicycle exerciseNormal activityBaseline ejection fractionExercise test resultsSubsequent cardiac eventsSupine bicycle exerciseVentricular function monitoringAcute myocardial infarctionChest painPeak exerciseBicycle exerciseAmbulatory patientsElectrocardiographic changesPoor outcomePrognostic informationFunction monitoring
1989
Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial
Wackers F, Terrin M, Kayden D, Knatterud G, Forman S, Braunwald E, Zaret B, Investigators. Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial. Journal Of The American College Of Cardiology 1989, 13: 998-1005. PMID: 2494246, DOI: 10.1016/0735-1097(89)90250-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorLeft ventricular ejection fractionInfarct-related arteryVentricular ejection fractionGlobal left ventricular ejection fractionRegional left ventricular functionLeft ventricular functionEjection fractionAcute myocardial infarctionRegional ejection fractionVentricular functionMyocardial infarctionMean global left ventricular ejection fractionIntravenous recombinant tissue-type plasminogen activatorRegional left ventricular ejection fractionEffect of thrombolysisMyocardial Infarction trialRegional ventricular functionTissue-type plasminogen activatorPatients 185Sustained reperfusionIntravenous streptokinaseAngiographic reperfusionThrombolytic therapyPatency rates
1988
Electrophysiologic effects of thrombolytic therapy in patients with a transmural anterior myocardial infarction complicated by left ventricular aneurysm formation
Sager P, Perlmutter R, Rosenfeld L, McPherson C, Wackers F, Batsford W. Electrophysiologic effects of thrombolytic therapy in patients with a transmural anterior myocardial infarction complicated by left ventricular aneurysm formation. Journal Of The American College Of Cardiology 1988, 12: 19-24. PMID: 3379204, DOI: 10.1016/0735-1097(88)90350-6.Peer-Reviewed Original ResearchConceptsGroup B patientsLeft ventricular aneurysm formationTransmural anterior myocardial infarctionGroup A patientsVentricular aneurysm formationAnterior myocardial infarctionThrombolytic therapyB patientsVentricular tachycardiaA patientsVentricular arrhythmiasMyocardial infarctionAneurysm formationNew bundle branch blockPeak creatine kinase-MB levelsLeft ventricular ejection fractionCreatine kinase-MB levelsClinical arrhythmic eventsEarly thrombolytic therapyCongestive heart failureVentricular ejection fractionSustained ventricular tachycardiaInduced ventricular arrhythmiasBundle branch blockPostmyocardial infarction patientsThe Role of Nuclear Cardiology in Assessment of Acute Myocardial Infarction
den D, Wackers F, Zaret B. The Role of Nuclear Cardiology in Assessment of Acute Myocardial Infarction. Cardiology Clinics 1988, 6: 81-95. PMID: 3048676, DOI: 10.1016/s0733-8651(18)30503-4.Peer-Reviewed Original ResearchConceptsConvalescent phaseVentricular functionExercise-induced ischemiaAcute myocardial infarctionSalvaged myocardiumThallium imagingThrombolytic therapyAcute interventionIschemic myocardiumMyocardial infarctionPrognostic informationFurther interventionMyocardial perfusionPerfusion imagingAmbulatory monitoringMetabolic imagingMyocardiumNuclear cardiologyAppropriate management strategiesInterventionImagingInfarctionIschemiaPatientsTherapy
1987
Right ventricular myocardial infarction with anterior wall left ventricular infarction: An autopsy study
Cabin H, Clubb K, Wackers F, Zaret B. Right ventricular myocardial infarction with anterior wall left ventricular infarction: An autopsy study. American Heart Journal 1987, 113: 16-23. PMID: 3799430, DOI: 10.1016/0002-8703(87)90004-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedFemaleHeart AneurysmHeart VentriclesHumansMaleMiddle AgedMyocardial InfarctionConceptsRight ventricular myocardial infarctionVentricular myocardial infarctionAnterior myocardial infarctionMyocardial infarctionVentricular infarctionVentricular free wallRadionuclide angiographyVentricular infarctAnterior wallFree wallInferior left ventricular infarctionRight ventricular free wallRight ventricular dysfunctionRight ventricular infarctRight ventricular necrosisLeft ventricular infarctionLeft ventricular free wallEquilibrium radionuclide angiographyVentricular necrosisVentricular dysfunctionAutopsy studyGlobal dysfunctionInfarctionTherapeutic implicationsClinical importance
1983
Serial radionuclide assessment of doxorubicin cardiotoxicity in cancer patients with abnormal baseline resting left ventricular performance
Choi B, Berger H, Schwartz P, Alexander J, Wackers F, Gottschalk A, Zaret B. Serial radionuclide assessment of doxorubicin cardiotoxicity in cancer patients with abnormal baseline resting left ventricular performance. American Heart Journal 1983, 106: 638-643. PMID: 6613807, DOI: 10.1016/0002-8703(83)90080-7.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionCongestive heart failureLeft ventricular performanceVentricular performanceEjection fractionAbnormal baselineHeart failureDoxorubicin therapyDoxorubicin cardiotoxicityRadionuclide angiocardiographyAbnormal left ventricular ejection fractionFinal left ventricular ejection fractionAntecedent cardiovascular diseaseSerial radionuclide studiesFirst-pass radionuclide angiocardiographyIdentification of patientsUse of doxorubicinSafe discontinuationThoracic radiationVentricular functionCancer patientsCumulative doseCardiovascular diseaseRadionuclide assessment
1982
Gold-195m, a new generator-produced short-lived radionuclide for sequential assessment of ventricular performance by first pass radionuclide angiocardiography
Wackers F, Giles R, Hoffer P, Lange R, Berger H, Zaret B, Pytlik L, Plankey M. Gold-195m, a new generator-produced short-lived radionuclide for sequential assessment of ventricular performance by first pass radionuclide angiocardiography. The American Journal Of Cardiology 1982, 50: 89-94. PMID: 7046410, DOI: 10.1016/0002-9149(82)90013-3.Peer-Reviewed Original ResearchRadionuclide angiographic exercise left ventricular performance in chronic aortic regurgitation: Relationship to resting echographic ventricular dimensions and systolic wall stress index
Lewis S, Riba A, Berger H, Davies R, Wackers F, Alexander J, Sands M, Cohen L, Zaret B. Radionuclide angiographic exercise left ventricular performance in chronic aortic regurgitation: Relationship to resting echographic ventricular dimensions and systolic wall stress index. American Heart Journal 1982, 103: 498-504. PMID: 7064791, DOI: 10.1016/0002-8703(82)90336-2.Peer-Reviewed Original ResearchConceptsChronic aortic regurgitationExercise reserveAortic regurgitationRadius/wall thickness ratioEjection fractionRadionuclide angiocardiographyLV dimensionsEchocardiographic LV dimensionsUpright bicycle exerciseFirst-pass radionuclide angiocardiographyM-mode echocardiographyWall stress indexAR patientsSymptomatic patientsBicycle exerciseVentricular dimensionsVentricular performanceExercise responseExercise performancePatientsEnd systoleEnd diastoleAbsolute changeRegurgitationWall thickness ratioRadionuclide Assessment of Left Ventricular Function in Patients Requiring Intraoperative Balloon Pump Assistance
Davies R, Laks H, Wackers F, Berger H, Williams B, Hammond G, Geha A, Gottschalk A, Zaret B. Radionuclide Assessment of Left Ventricular Function in Patients Requiring Intraoperative Balloon Pump Assistance. The Annals Of Thoracic Surgery 1982, 33: 123-131. PMID: 7065774, DOI: 10.1016/s0003-4975(10)61896-6.Peer-Reviewed Original ResearchConceptsLV ejection fractionPerioperative myocardial infarctionIntraaortic balloon pump assistanceLeft ventricular functionEjection fractionMyocardial infarctionPreoperative valuesCardiopulmonary bypassVentricular functionPump assistanceCreatine kinase MB fractionExercise radionuclide studiesIntraaortic balloon assistanceNormal LV responseNew Q wavesLV dysfunctionMyocardial depressionBalloon assistanceLV performancePreoperative measurementsLV responseRadionuclide assessmentQ wavesRadionuclide studiesPatients
1981
Pathophysiologic correlates of right ventricular thallium-201 uptake in a canine model.
Wackers F, Klay J, Laks H, Schnitzer J, Zaret B, Geha A. Pathophysiologic correlates of right ventricular thallium-201 uptake in a canine model. Circulation 1981, 64: 1256-1264. PMID: 6457702, DOI: 10.1161/01.cir.64.6.1256.Peer-Reviewed Original ResearchRadionuclide assessment of peripheral intravascular capacity: a technique to measure intravascular volume changes in the capacitance circulation in man.
Rutlen D, Wackers F, Zaret B. Radionuclide assessment of peripheral intravascular capacity: a technique to measure intravascular volume changes in the capacitance circulation in man. Circulation 1981, 64: 146-152. PMID: 6786793, DOI: 10.1161/01.cir.64.1.146.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood VolumeCoronary CirculationForearmHeart VentriclesHumansLegNitroglycerinPlethysmographyRadionuclide ImagingConceptsCapacitance vasculatureVascular capacityIntravascular spaceIntegrated cardiovascular functionIntravascular volume changesGamma camera imagingVenous returnLeg elevationSublingual nitroglycerinVentricular performanceContralateral forearmCardiovascular functionCardiac performanceRadionuclide assessmentBlood volumeRadionuclide imagingPathophysiologic statesPatientsCardiac imagingTwo minutesForearmMenNitroglycerinCountVasculatureMultigated equilibrium radionuclide angiocardiography: improved detection of left ventricular wall motion abnormalities and aneurysms by the addition of the left lateral view.
Kelly MJ, Giles RW, Simon TR, Berger HJ, Langou RA, Zaret BL, Wackers FJ. Multigated equilibrium radionuclide angiocardiography: improved detection of left ventricular wall motion abnormalities and aneurysms by the addition of the left lateral view. Radiology 1981, 139: 167-73. PMID: 7208919, DOI: 10.1148/radiology.139.1.7208919.Peer-Reviewed Original ResearchExercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiograms, and angiographically normal coronary arteries.
Berger HJ, Sands MJ, Davies RA, Wackers FJ, Alexander J, Lachman AS, Williams BW, Zaret BL. Exercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiograms, and angiographically normal coronary arteries. Annals Of Internal Medicine 1981, 94: 186-91. PMID: 7469209, DOI: 10.7326/0003-4819-94-2-186.Peer-Reviewed Original ResearchConceptsNormal coronary arteriesLeft ventricular performanceChest painVentricular performanceCoronary arteryExercise electrocardiogramAbnormal ejection fraction responseMaximal upright bicycle exerciseCoronary arterial spasmUpright bicycle exerciseEjection fraction responseFirst-pass radionuclide angiocardiographyThallium-201 imagingErgonovine testingVentricular dysfunctionArterial spasmBicycle exerciseErgonovine provocationAdditional patientsTreadmill exercisePerfusion defectsRadionuclide angiocardiographyRegional dysfunctionPatientsFraction response
1980
Comparison of exercise radionuclide angiocardiography and thallium-201 myocardial perfusion imaging in coronary artery disease
Johnstone D, Sands M, Berger H, Reduto L, Lachman A, Wackers F, Cohen L, Gottschalk A, Zaret B. Comparison of exercise radionuclide angiocardiography and thallium-201 myocardial perfusion imaging in coronary artery disease. The American Journal Of Cardiology 1980, 45: 1113-1119. PMID: 7377108, DOI: 10.1016/0002-9149(80)90467-1.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseExercise thallium studiesArtery diseaseVentricular reserveEjection fractionThallium studiesPerfusion defectsLeft ventricular ejection fractionThallium-201 myocardial perfusion imagingThallium-201 myocardial perfusionExercise-induced perfusion defectsRegional wall motion abnormalitiesExercise thallium imagesNormal coronary arteriesUpright bicycle exerciseSingle-vessel diseaseT segment depressionVentricular ejection fractionAbnormal exerciseThallium perfusion defectsWall motion abnormalitiesMyocardial perfusion imagingRegional wall motionExercise radionuclideIschemic S