2017
Evaluating biomarkers for prognostic enrichment of clinical trials
Kerr KF, Roth J, Zhu K, Thiessen-Philbrook H, Meisner A, Wilson FP, Coca S, Parikh CR. Evaluating biomarkers for prognostic enrichment of clinical trials. Clinical Trials 2017, 14: 629-638. PMID: 28795578, PMCID: PMC5714681, DOI: 10.1177/1740774517723588.Peer-Reviewed Original ResearchConceptsPrognostic enrichmentTrial eligibility criteriaClinical trialsEligibility criteriaTrial resultsClinical trial sample sizesOutcomes of interestTrial sample sizeTrial metricsOnly patientsBACKGROUND/Prognostic biomarkerPrognostic performanceHigh riskClinical settingScreening costsBiomarkersTrialsScreening thresholdCalendar timeTrial costsSample sizePatients
2014
Dialysis versus Nondialysis in Patients with AKI: A Propensity-Matched Cohort Study
Wilson FP, Yang W, Machado CA, Mariani LH, Borovskiy Y, Berns JS, Feldman HI. Dialysis versus Nondialysis in Patients with AKI: A Propensity-Matched Cohort Study. Clinical Journal Of The American Society Of Nephrology 2014, 9: 673-681. PMID: 24651073, PMCID: PMC3974360, DOI: 10.2215/cjn.07630713.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedBiomarkersCreatinineFemaleHospitalizationHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPatient SelectionPennsylvaniaPropensity ScoreProportional Hazards ModelsRenal DialysisRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeConceptsInitiation of dialysisSerum creatinine concentrationCreatinine concentrationDialysis initiationDialyzed patientsSevere AKICohort studyPropensity-matched cohort studyPropensity scoreElevated creatinine levelOverall hazard ratioGreater survival benefitProportional hazards analysisAcute care hospitalsTime-varying propensity scoresPennsylvania Health SystemCause mortalityCreatinine levelsHazard ratioSurvival benefitCare hospitalDL increaseNondialyzed patientsPatient factorsLaboratory variables