2022
Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy
Baker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. Journal For ImmunoTherapy Of Cancer 2022, 10: e004421. PMID: 35354588, PMCID: PMC8968986, DOI: 10.1136/jitc-2021-004421.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney injuryImmune checkpoint inhibitor therapyCheckpoint inhibitor therapyICI therapyKidney injuryInhibitor therapyInterstitial nephritisTime-varying Cox proportional hazards modelsHigher peak serum creatinineSevere acute kidney injuryCancer typesCox proportional hazards modelAssociations of biopsyBaseline laboratory valuesObservational cohort studyPeak serum creatinineFavorable treatment responseProportional hazards modelAKI patientsTherapy initiationCohort studySerum creatinineUnivariable analysisImmune activation
2013
The impact of documentation of severe acute kidney injury on mortality
Wilson FP, Bansal AD, Jasti SK, Lin JJ, Shashaty MG, Berns JS, Feldman HI, Fuchs BD. The impact of documentation of severe acute kidney injury on mortality. Clinical Nephrology 2013, 80: 417-425. PMID: 24075024, PMCID: PMC4018223, DOI: 10.5414/cn108072.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBaseline creatinineKidney injuryHigher Sequential Organ Failure Assessment scoreDocumentation of AKIRecognition of AKISequential Organ Failure Assessment scoreAngiotensin receptor blocker medicationHospital acute kidney injuryOrgan Failure Assessment scoreSevere acute kidney injuryHigher baseline creatinineHigher peak creatinineRetrospective cohort studyImproved clinical outcomesUniversity Health SystemSeverity of diseaseNephrology consultationPeak creatinineRapid discontinuationCohort studyImproved survivalClinical outcomesIllness severityKidney disease