2022
Clinically adjudicated deceased donor acute kidney injury and graft outcomes
Mansour SG, Khoury N, Kodali R, Virmani S, Reese PP, Hall IE, Jia Y, Yamamoto Y, Thiessen-Philbrook HR, Obeid W, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Singh P, Weng FL, Moledina DG, Greenberg JH, Wilson FP, Parikh CR. Clinically adjudicated deceased donor acute kidney injury and graft outcomes. PLOS ONE 2022, 17: e0264329. PMID: 35239694, PMCID: PMC8893682, DOI: 10.1371/journal.pone.0264329.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryGraft failureAKI phenotypesKidney injuryUrine biomarkersLack of associationAKI casesGraft functionHigher DGFPotential kidneyGraft outcomeDeceased donorsOrgan utilizationMCP-1YKL-40Donor StudyEGFRDGFAncillary analysisAvailable chartsBiomarkersInjuryPhenotypeAssociation
2020
Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter Study
Moledina DG, Belliveau O, Yamamoto Y, Arora T, Carey KA, Churpek M, Martin M, Partridge CM, Mansour SG, Parikh CR, Koyner JL, Wilson FP. Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter Study. American Journal Of Kidney Diseases 2020, 77: 547-549. PMID: 33075389, PMCID: PMC8672301, DOI: 10.1053/j.ajkd.2020.08.013.Peer-Reviewed Original ResearchAcute kidney injury is associated with reversible platelet dysfunction in hospitalized patients with decompensated cirrhosis
Zanetto A, Rinder H, Deng Y, Ciarleglio M, Wilson F, Bulato C, Simioni P, Garcia-Tsao G. Acute kidney injury is associated with reversible platelet dysfunction in hospitalized patients with decompensated cirrhosis. Digestive And Liver Disease 2020, 52: e13. DOI: 10.1016/j.dld.2019.12.031.Peer-Reviewed Original Research
2018
Acute Kidney Injury in Real Time: Prediction, Alerts, and Clinical Decision Support
Wilson FP, Greenberg JH. Acute Kidney Injury in Real Time: Prediction, Alerts, and Clinical Decision Support. Nephron 2018, 140: 116-119. PMID: 30071528, PMCID: PMC6165685, DOI: 10.1159/000492064.Commentaries, Editorials and LettersConceptsPresence of AKIAcute kidney injury (AKI) researchShort-term adverse outcomesBest practice advisoryDetection of AKIEHR-based toolsAcute kidney injuryChronic kidney diseaseKidney injurySerum creatinineClinical decision supportAdverse outcomesElectronic health record systemsKidney diseaseAdministrative codingHarmful sequelaeHealth record systemsAKIInjury researchProvider behaviorRecord systemSequelaeCreatinineInjuryDisease
2017
Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery
Lin H, Scherzer R, Philbrook HT, Coca SG, Wilson FP, Garg AX, Shlipak MG, Parikh CR. Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery. Biomarkers In Medicine 2017, 11: 1091-1102. PMID: 29172665, PMCID: PMC5753615, DOI: 10.2217/bmm-2017-0060.Peer-Reviewed Original ResearchConceptsAdvanced acute kidney injuryAcute kidney injuryKidney injuryCardiac surgeryPatient groupSingle biomarkerIndividual biomarkersPostoperative biomarkersDistinct biomarker patternsNT-proBNPSecondary outcomesIL-10Clinical variablesIL-6Plasma biomarkersCK-MBRisk discriminationAbstractTextH-FABPBiomarkersSignificant differencesSurgeryBiomarker patternsInjuryOutcomesInformation Technology and Acute Kidney Injury: Alerts, Alarms, Bells, and Whistles
Wilson FP. Information Technology and Acute Kidney Injury: Alerts, Alarms, Bells, and Whistles. Advances In Kidney Disease And Health 2017, 24: 241-245. PMID: 28778364, PMCID: PMC5650118, DOI: 10.1053/j.ackd.2017.05.007.Commentaries, Editorials and LettersApproaches to Predicting Outcomes in Patients with Acute Kidney Injury
Saly D, Yang A, Triebwasser C, Oh J, Sun Q, Testani J, Parikh CR, Bia J, Biswas A, Stetson C, Chaisanguanthum K, Wilson FP. Approaches to Predicting Outcomes in Patients with Acute Kidney Injury. PLOS ONE 2017, 12: e0169305. PMID: 28122032, PMCID: PMC5266278, DOI: 10.1371/journal.pone.0169305.Peer-Reviewed Original ResearchConceptsAcute kidney injuryLength of stayKidney injuryReceiver operator characteristic curveOutcomes of interestOperator characteristic curveValidation cohortClinical eventsAccurate prognosticationOutcome eventsPredicting OutcomePrognostic modelDeath predictionLab valuesCharacteristic curveGood discrimination abilityPatientsStayInjuryDialysisModel discriminationOutcomesDaysMedicationsMorbidity
2016
Preventing acute kidney injury through nephrotoxin management
Perazella MA, Wilson FP. Preventing acute kidney injury through nephrotoxin management. Nature Reviews Nephrology 2016, 12: 511-512. PMID: 27374917, DOI: 10.1038/nrneph.2016.95.Commentaries, Editorials and LettersProvider acceptance of an automated electronic alert for acute kidney injury
Oh J, Bia JR, Ubaid-Ullah M, Testani JM, Wilson FP. Provider acceptance of an automated electronic alert for acute kidney injury. Clinical Kidney Journal 2016, 9: 567-571. PMID: 27478598, PMCID: PMC4957729, DOI: 10.1093/ckj/sfw054.Peer-Reviewed Original ResearchAcute kidney injuryElectronic alertsAKI alertsKidney injuryPatient careAKI alert systemElectronic AKI alertsNon-physician providersPercent of respondersHealthcare provider opinionsElectronic medical recordsClinical decision support systemMedical recordsSingle hospitalProviders' opinionsProvider acceptanceTrial durationPaucity of informationPatient-specific informationTrialsSignificant differencesAlert trialsInjuryApprovalCare
2014
A trial of in-hospital, electronic alerts for acute kidney injury: Design and rationale
Wilson FP, Reese PP, Shashaty MG, Ellenberg SS, Gitelman Y, Bansal AD, Urbani R, Feldman HI, Fuchs B. A trial of in-hospital, electronic alerts for acute kidney injury: Design and rationale. Clinical Trials 2014, 11: 521-529. PMID: 25023200, PMCID: PMC4156885, DOI: 10.1177/1740774514542619.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryElectronic alert systemHospitalized patientsElectronic alertsInformed consentStage 1 acute kidney injuryStage 3 acute kidney injuryAcute kidney injury severityStudy outcomesAcute kidney injury alertsLow-risk interventionBroad inclusion criteriaInpatient mortalitySerum creatinineMedical recordsClinical trialsPatient outcomesInclusion criteriaProvider recognitionEarly deathDichotomous outcomesInjury severityPatientsInjury
2011
Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD)
Wilson FP, Berns JS. Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD). Clinical Nephrology 2011, 77: 329-331. PMID: 22445477, PMCID: PMC3359699, DOI: 10.5414/cn106993.Peer-Reviewed Original ResearchConceptsContinuous renal replacement therapyContinuous venovenous hemodialysisAcute kidney injuryRenal replacement therapyPopulation of patientsDialysis flow rateKidney injuryVancomycin levelsIntensive careReplacement therapyIntermittent dialysisSubtherapeutic levelsLow bloodNephrology traineesAntibioticsHemodialysisPatientsInjuryTherapyPopulationVancomycinBloodDialysisCare