2023
Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19
Menez S, Coca S, Moledina D, Wen Y, Chan L, Thiessen-Philbrook H, Obeid W, Garibaldi B, Azeloglu E, Ugwuowo U, Sperati C, Arend L, Rosenberg A, Kaushal M, Jain S, Wilson F, Parikh C, Consortium T, Deng J, Atta M, Bagnasco S, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19. American Journal Of Kidney Diseases 2023, 82: 322-332.e1. PMID: 37263570, PMCID: PMC10229201, DOI: 10.1053/j.ajkd.2023.03.010.Peer-Reviewed Original ResearchConceptsSoluble tumor necrosis factor receptor 1Major adverse kidney eventsAdverse kidney eventsAdverse kidney outcomesAcute kidney injuryKidney eventsTumor necrosis factor receptor 1Necrosis factor receptor 1Plasma biomarkersKidney outcomesC-indexFactor receptor 1Hospitalized patientsCOVID-19KDIGO stage 3 acute kidney injuryDialysis-requiring acute kidney injuryStage 3 acute kidney injuryLong-term adverse health outcomesReceptor 1Long-term kidney dysfunctionAvailable blood samplesIdentification of patientsProportional hazards regressionAdverse health outcomesCOVID-19 hospitalization
2012
Predictors of Death and Dialysis in Severe AKI: The UPHS-AKI Cohort
Wilson FP, Yang W, Feldman HI. Predictors of Death and Dialysis in Severe AKI: The UPHS-AKI Cohort. Clinical Journal Of The American Society Of Nephrology 2012, 8: 527-537. PMID: 23258795, PMCID: PMC3613955, DOI: 10.2215/cjn.06450612.Peer-Reviewed Original ResearchConceptsSevere AKIC-indexIntensive care unit locationPredictors of deathEffective risk stratificationEndpoint of deathMore effective therapeutic interventionsHigh-risk subgroupsHarrell's C-indexLower overall mortalityProportional hazards modelEffective therapeutic interventionsPennsylvania Health SystemBaseline creatinineHospital AKIPressor medicationsSerum creatinineClinical factorsDerivation cohortHigher creatinineHospital admissionOverall mortalityLiver diseaseRisk stratificationValidation cohort