Genome-wide Association Study for AKI
Bhatraju P, Stanaway I, Palmer M, Menon R, Schaub J, Menez S, Srivastava A, Wilson F, Kiryluk K, Palevsky P, Naik A, Sakr S, Jarvik G, Parikh C, Ware L, Ikizler T, Siew E, Chinchilli V, Coca S, Garg A, Go A, Kaufman J, Kimmel P, Himmelfarb J, Wurfel M. Genome-wide Association Study for AKI. Kidney360 2023, 4: 870-880. PMID: 37273234, PMCID: PMC10371295, DOI: 10.34067/kid.0000000000000175.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGene locusAssociation studiesSingle-cell RNA sequencing dataHealthy living donorsLoop of HenleThick ascending limbWide significant associationsGenetic variantsGenome-wide significanceRNA sequencing dataKidney biopsyCommon genetic riskLiving donorsSubsequent sequelaeSerial evaluationFunctional annotationIntergenic regionAscending limbGene expressionSequencing dataRisk of AKIKidney biopsy tissueProximal tubular epithelial cellsMember 1 geneEpigenome-Wide Meta-Analysis Reveals Differential DNA Methylation Associated With Estimated Glomerular Filtration Rate Among African American Men With HIV
Chen J, Hui Q, Wang Z, Wilson F, So-Armah K, Freiberg M, Justice A, Xu K, Zhao W, Ammous F, Smith J, Kardia S, Gwinn M, Marconi V, Sun Y. Epigenome-Wide Meta-Analysis Reveals Differential DNA Methylation Associated With Estimated Glomerular Filtration Rate Among African American Men With HIV. Kidney International Reports 2023, 8: 1076-1086. PMID: 37180517, PMCID: PMC10166785, DOI: 10.1016/j.ekir.2023.02.1085.Peer-Reviewed Original ResearchEpigenome-wide association studiesDNA methylationGlomerular filtration rateRenal diseaseFinger protein 20Differential DNA methylationKidney functionFiltration rateAfrican ancestryEnd-stage renal diseaseDifferent populationsProtein 20Ancestral groupsRenal disease progressionAssociation studiesDifferent ancestral groupsMethylationAfrican American menAncestryEuropean ancestryStudy cohortIndependent African American samplesDisease progressionFaster progressionGeneral population