2001
Topiramate Rapidly Raises Brain GABA in Epilepsy Patients
Petroff O, Hyder F, Rothman D, Mattson R. Topiramate Rapidly Raises Brain GABA in Epilepsy Patients. Epilepsia 2001, 42: 543-548. PMID: 11440351, DOI: 10.1046/j.1528-1157.2001.18800.x.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnticonvulsantsBrain ChemistryCarnosineDose-Response Relationship, DrugDrug Administration ScheduleEpilepsy, Complex PartialFructoseGamma-Aminobutyric AcidHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyOccipital LobePyrrolidinonesStimulation, ChemicalTopiramateConceptsBrain GABAOral doseLong-term pharmacodynamic effectsFirst oral doseComplex partial seizuresTPM dosesTPM therapyFirst doseFurther seizuresPartial seizuresPharmacodynamic effectsEpilepsy patientsOccipital cortexPatientsGABAPartial protectionDoseFirst dayAcid metabolismDose responseHomocarnosineSeizuresVivo measurementsSurface coilTopiramateHomocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures
Petroff O, Hyder F, Rothman D, Mattson R. Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures. Neurology 2001, 56: 709-715. PMID: 11274303, DOI: 10.1212/wnl.56.6.709.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarnosineEpilepsy, Complex PartialFemaleGamma-Aminobutyric AcidHumansMagnetic Resonance SpectroscopyMaleMiddle AgedMyoclonic Epilepsy, JuvenileTime FactorsConceptsComplex partial seizuresJuvenile myoclonic epilepsyGamma-aminobutyric acidHigher homocarnosine levelsGood seizure controlSeizure controlPoor seizure controlHomocarnosine levelsPartial seizuresMyoclonic epilepsyBrain gamma-aminobutyric acidLower GABA levelsType of epilepsyLower gamma-aminobutyric acidGABA levelsOccipital cortexPatientsVisual cortexEpilepsyValproateLamotrigineSeizuresCortexHomocarnosineMR spectrometer
2000
Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients
Petroff O, Hyder F, Rothman D, Mattson R. Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients. Epilepsia 2000, 41: 675-680. PMID: 10840398, DOI: 10.1111/j.1528-1157.2000.tb00227.x.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidFirst oral doseFirst doseOral doseAntiepileptic drugsEffect of gabapentinStandard daily doseSingle high doseGBP therapyDaily therapyNeuropathic painAnticonvulsant effectsFurther seizuresDaily doseEpilepsy patientsOccipital cortexHigh doseGabapentinPatientsPartial protectionDoseHomocarnosineTherapyVivo measurements
1999
Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial Seizures
Petroff O, Hyder F, Collins T, Mattson R, Rothman D. Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial Seizures. Epilepsia 1999, 40: 958-964. PMID: 10403220, DOI: 10.1111/j.1528-1157.1999.tb00803.x.Peer-Reviewed Original ResearchConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidDose of vigabatrinComplex partial seizuresPartial seizuresRefractory complex partial seizuresFirst oral doseVGB therapyFirst doseFurther seizuresAdjunct therapyDay dosingOral doseAcute effectsOral administrationOccipital cortexMedian increasePatientsVigabatrinChronic effectsNormal levelsPartial protectionSeizuresDoseHomocarnosineLocalized 1H NMR measurements of 2‐pyrrolidinone in human brain in vivo
Hyder F, Petroff O, Mattson R, Rothman D. Localized 1H NMR measurements of 2‐pyrrolidinone in human brain in vivo. Magnetic Resonance In Medicine 1999, 41: 889-896. PMID: 10332870, DOI: 10.1002/(sici)1522-2594(199905)41:5<889::aid-mrm6>3.0.co;2-r.Peer-Reviewed Original ResearchGABA Changes with Vigabatrin in the Developing Human Brain
Novotny E, Hyder F, Shevell M, Rothman D. GABA Changes with Vigabatrin in the Developing Human Brain. Epilepsia 1999, 40: 462-466. PMID: 10219272, DOI: 10.1111/j.1528-1157.1999.tb00741.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsBrainChildChild, PreschoolEpilepsyFemaleGamma-Aminobutyric AcidHumansInfantMagnetic Resonance SpectroscopyMaleOccipital LobeVigabatrinConceptsBrain GABA levelsGABA levelsBrain GABAVGB treatmentRole of GABASeizure controlGABA changesSeizure susceptibilityPediatric epilepsyEpileptic focusOccipital lobeNervous systemEpileptic regionsVigabatrinEpilepsyGABAGABA metabolismTreatmentAge 1Noninvasive measurementHuman brainSubjectsDrugsFivefold increaseChildrenTopiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy
Petroff O, Hyder F, Mattson R, Rothman D. Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy. Neurology 1999, 52: 473-478. PMID: 10025774, DOI: 10.1212/wnl.52.3.473.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnticonvulsantsBrainCarnosineEpilepsyFemaleFructoseGamma-Aminobutyric AcidHumansMagnetic Resonance SpectroscopyMaleMiddle AgedPyrrolidinonesTopiramateConceptsBrain gamma-aminobutyric acidGamma-aminobutyric acidComplex partial seizuresAntiepileptic actionPartial seizuresRefractory complex partial seizuresNew antiepileptic medicationsEffects of topiramateNew antiepileptic drugsDrug-free volunteersMultiple putative mechanismsPotent antiepileptic actionAntiepileptic medicationsAdditional patientsAntiepileptic drugsControl subjectsOccipital cortexTopiramatePatientsPutative mechanismsHomocarnosineEpilepsySeizuresVivo measurementsSurface coil
1998
Vigabatrin increases human brain homocarnosine and improves seizure control
Petroff O, Mattson R, Behar K, Hyder F, Rothman D. Vigabatrin increases human brain homocarnosine and improves seizure control. Annals Of Neurology 1998, 44: 948-952. PMID: 9851440, DOI: 10.1002/ana.410440614.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidSeizure controlGABA concentrationAddition of vigabatrinLow-dose vigabatrinImproved seizure controlMean GABA concentrationAntiepileptic drug vigabatrinInhibitory neuromodulatorDaily doseGABAergic neuronsGABA levelsLarge dosesHomocarnosine concentrationsVigabatrinDrug vigabatrinHomocarnosinePatientsHuman brainMagnetic resonance spectroscopyControlNeuromodulatorsNeuronsDoseDoses