2012
Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone
Lacar B, Herman P, Platel JC, Kubera C, Hyder F, Bordey A. Neural Progenitor Cells Regulate Capillary Blood Flow in the Postnatal Subventricular Zone. Journal Of Neuroscience 2012, 32: 16435-16448. PMID: 23152626, PMCID: PMC3520061, DOI: 10.1523/jneurosci.1457-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAnimals, NewbornAstrocytesCalcium SignalingCapillariesCerebral VentriclesCerebrovascular CirculationElectric StimulationElectroporationFemaleFluorescent Antibody TechniqueImage Processing, Computer-AssistedLaser-Doppler FlowmetryMaleMiceMuscle TonusMuscle, Smooth, VascularNeural Stem CellsPericytesVasoconstrictionVasodilationConceptsNeural progenitor cellsSubventricular zoneB cellsBlood flowSVZ cellsPurinergic receptorsPostnatal subventricular zoneVascular responsesCapillary constrictionTransgenic miceElectrical stimulationCalcium increaseBlood flow increasesLaser Doppler flowmetryCapillary blood flowAstrocyte-like cellsReceptor agonist UTPNeonatal electroporationNeurometabolic couplingIntraventricular injectionVasodilating factorsAcute slicesYoung miceDoppler flowmetryHemodynamic response
2001
Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging
Shulman R, Hyder F, Rothman D. Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6417-6422. PMID: 11344262, PMCID: PMC33483, DOI: 10.1073/pnas.101129298.Peer-Reviewed Original ResearchConceptsLactate concentrationBrain activationBrain lactate concentrationCerebral blood flowAdult mammalian brainBasal glucose oxidationPositron emission tomographyGlucose oxidationGlucose indexCerebral energeticsFunctional imaging dataNeurophysiological valuesBlood flowGlucose metabolismNeurotransmitter clearanceNeurochemical basisLactate effluxMammalian brainBasal physiological conditionsNeurotransmitter releaseAnaerobic glucose metabolismFunctional imagingComplete dataBrain activityMetabolic consumption rate