2014
Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity
Lin AL, Coman D, Jiang L, Rothman DL, Hyder F. Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1440-1443. PMID: 24984898, PMCID: PMC4158670, DOI: 10.1038/jcbfm.2014.114.Peer-Reviewed Original ResearchConceptsOld CR ratsNeuronal activityYoung controlsCR ratsCaloric restriction (CR) prolongs lifespanHealthy agingNeuronal glucose oxidationBrain mitochondrial functionNeuronal energy productionMitochondrial functionAge-related declineNeurotransmitter cyclingOlder controlsNeurotransmission ratesBrain physiologyRatsGlucose oxidationProlong lifespanVivo nuclear magnetic resonance (NMR) spectroscopyMagnetic resonance spectroscopyDetrimental effectsAgingControl
2013
Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels
Hyder F, Rothman DL, Bennett MR. Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3549-3554. PMID: 23319606, PMCID: PMC3587194, DOI: 10.1073/pnas.1214912110.Peer-Reviewed Original ResearchConceptsGlucose oxidation ratesCerebral cortexNeuronal activityActivity levelsGlucose metabolic dataHuman cerebral cortexMetabolic dataOxidative demandAwake valuesCortical neuronsSynaptic transmissionGlucose metabolismAwake stateSensory stimulationAnatomic dataRatsCortexMammalian speciesIsoelectricityMagnetic resonance spectroscopy resultsSignaling requirementsAstrocytesCell membraneLevelsNeurons
2000
Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study
Hyder F, Kennan R, Kida I, Mason G, Behar K, Rothman D. Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 485-498. PMID: 10724113, DOI: 10.1097/00004647-200003000-00007.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCapillary bedOxygen deliveryML xCerebral oxygen deliveryNicotine hydrogen tartrateRespective control conditionsValues of CBFMorphine anesthesiaSensorimotor cortexForepaw stimulationSodium pentobarbitalRat brainBlood flowCMRO2Mature ratsCortical activityResonance imagingBasal conditionsPercentage changeRatsAdministrationCBF
1999
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics
Rothman D, Sibson N, Hyder F, Shen J, Behar K, Shulman R. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 1165-1177. PMID: 10466144, PMCID: PMC1692640, DOI: 10.1098/rstb.1999.0472.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGlutamate-glutamine cycleNerve terminalsNeurotransmitter cycleGlucose metabolismBlood oxygenation level-dependent magnetic resonance imagingLevel-dependent magnetic resonance imagingBrain glucose oxidationCortical glucose metabolismMagnetic resonance spectroscopy studyCortex of ratsMagnetic resonance imagingFunctional imaging studiesSpecific neuronal activityOxidative glucose metabolismGlial cellsNeuronal activityResonance imagingImaging studiesHuman cortexBrain functionBrain activityRatsCortexGlucose oxidationGlutamate
1994
Dynamic Magnetic Resonance Imaging of the Rat Brain during Forepaw Stimulation
Hyder F, Behar K, Martin M, Blamire A, Shulman R. Dynamic Magnetic Resonance Imaging of the Rat Brain during Forepaw Stimulation. Cerebrovascular And Brain Metabolism Reviews 1994, 14: 649-655. PMID: 8014212, DOI: 10.1038/jcbfm.1994.81.Peer-Reviewed Original ResearchConceptsSomatosensory areaChloralose-anesthetized ratsDynamic magnetic resonance imagingMagnetic resonance imagingForelimb motorForepaw stimulationRat brainBrain mapping methodsElectrical stimulationMR signal intensityParietal cortexResonance imagingBrain tissueCoronal planeFractional signal changeStimulationSignal changesOxygenation stateSignal intensityRatsAnteriorCortexBloodBrain