2013
Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy
Hyder F, Fulbright RK, Shulman RG, Rothman DL. Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 339-347. PMID: 23299240, PMCID: PMC3587823, DOI: 10.1038/jcbfm.2012.207.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance spectroscopy studyAwake resting stateFuture clinical investigationsMagnetic resonance imagingHigh resting activityAwake human brainGray matter regionsGlutamatergic functionGlutamatergic signalingMetabolic measuresClinical investigationAwake stateResting activityVisual cortexGlucose utilizationResonance imaging
1999
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics
Rothman D, Sibson N, Hyder F, Shen J, Behar K, Shulman R. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 1165-1177. PMID: 10466144, PMCID: PMC1692640, DOI: 10.1098/rstb.1999.0472.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGlutamate-glutamine cycleNerve terminalsNeurotransmitter cycleGlucose metabolismBlood oxygenation level-dependent magnetic resonance imagingLevel-dependent magnetic resonance imagingBrain glucose oxidationCortical glucose metabolismMagnetic resonance spectroscopy studyCortex of ratsMagnetic resonance imagingFunctional imaging studiesSpecific neuronal activityOxidative glucose metabolismGlial cellsNeuronal activityResonance imagingImaging studiesHuman cortexBrain functionBrain activityRatsCortexGlucose oxidationGlutamate