2017
A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus
Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E. A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus. Antimicrobial Agents And Chemotherapy 2017, 61: 10.1128/aac.00113-17. PMID: 28438938, PMCID: PMC5487661, DOI: 10.1128/aac.00113-17.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntifreeze ProteinsBiofilmsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsStaphylococcus aureusTicksConceptsNovel alternative therapeutic strategyAlternative therapeutic strategiesEfficacy of antibioticsTherapeutic strategiesTransgenic miceBacterial infectionsInfection modelDifferent antibioticsAntibioticsAntibiotic resistanceStaphylococcus aureusPotency of antibioticsClinical pathogensPeptides representativeImproved permeationPathogensPotent antibiofilm propertiesIAFGP
2014
Antivirulence Properties of an Antifreeze Protein
Heisig M, Abraham NM, Liu L, Neelakanta G, Mattessich S, Sultana H, Shang Z, Ansari JM, Killiam C, Walker W, Cooley L, Flavell RA, Agaisse H, Fikrig E. Antivirulence Properties of an Antifreeze Protein. Cell Reports 2014, 9: 417-424. PMID: 25373896, PMCID: PMC4223805, DOI: 10.1016/j.celrep.2014.09.034.Peer-Reviewed Original ResearchConceptsAntifreeze proteinsDiverse bacteriaProtein bindsWild-type animalsBiofilm formationAntivirulence agentsIAFGPMethicillin-resistant Staphylococcus aureusHost controlProteinAntifreeze glycoproteinsIxodes scapularisAntivirulence propertiesBacteriaSeptic shockTherapeutic strategiesBacterial infectionsInfectious diseasesMicrobesStaphylococcus aureusFliesBindsInfectionCatheter tubingPathogens
2001
Inhibition of Borrelia burgdorferi-Tick Interactions In Vivo by Outer Surface Protein A Antibody
Pal U, Montgomery R, Lusitani D, Voet P, Weynants V, Malawista S, Lobet Y, Fikrig E. Inhibition of Borrelia burgdorferi-Tick Interactions In Vivo by Outer Surface Protein A Antibody. The Journal Of Immunology 2001, 166: 7398-7403. PMID: 11390491, DOI: 10.4049/jimmunol.166.12.7398.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntibodies, BacterialAntibodies, MonoclonalAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBinding Sites, AntibodyBorrelia burgdorferi GroupDigestive SystemEpitopesFemaleImmune SeraInjections, IntraperitonealInjections, SubcutaneousIxodesLipoproteinsLyme DiseaseLyme Disease VaccinesMiceMice, SCIDMutationProtein Structure, TertiaryRecombinant ProteinsConceptsB. burgdorferi sensu strictoBurgdorferi sensu strictoB. burgdorferi N40Treatment of miceOuter Surface ProteinsB. burgdorferi sensu lato genospeciesSurface protein AOuter surface protein ASCID miceMurine modelB. burgdorferi attachmentLyme diseaseMiceB. burgdorferiBorrelia afzeliiB. afzeliiTick gutBorrelia gariniiOspAVivoAdherenceAntiserumPresent studySurface proteinsGut
1998
Human Granulocytic Ehrlichiosis During Pregnancy Treated Successfully with Rifampin
Buitrago MI, IJdo JW, Rinaudo P, Simon H, Copel J, Gadbaw J, Heimer R, Fikrig E, Bia FJ. Human Granulocytic Ehrlichiosis During Pregnancy Treated Successfully with Rifampin. Clinical Infectious Diseases 1998, 27: 213-215. PMID: 9675481, DOI: 10.1086/517678.Peer-Reviewed Case Reports and Technical Notes