2019
Polymicrobial Nature of Tick-Borne Diseases
Sanchez-Vicente S, Tagliafierro T, Coleman J, Benach J, Tokarz R, Azad A, Fikrig E, Munderloh U, Telford S. Polymicrobial Nature of Tick-Borne Diseases. MBio 2019, 10: e02055-19. PMID: 31506314, PMCID: PMC6737246, DOI: 10.1128/mbio.02055-19.Peer-Reviewed Original ResearchConceptsPolymicrobial infectionsClinical spectrumTick-borne diseasesFatal infectionPowassan virusDisproportionate incidenceTick-borne diseaseDifficult diagnosisNew pathogensNew agentsPolymicrobial natureDisease severityInfectionDiseaseLyme diseasePrevalent pathogenBorreliaHigh rateIncidenceDiagnosisSeverityRickettsiaTick vectorVirusClimate change
2006
The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks
Li X, Pal U, Ramamoorthi N, Liu X, Desrosiers DC, Eggers CH, Anderson JF, Radolf JD, Fikrig E. The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Molecular Microbiology 2006, 63: 694-710. PMID: 17181780, DOI: 10.1111/j.1365-2958.2006.05550.x.Peer-Reviewed Original Research
2000
The Emergence of Another Tickborne Infection in the 12-Town Area around Lyme, Connecticut: Human Granulocytic Ehrlichiosis
IJdo J, Meek J, Cartter M, Magnarelli L, Wu C, Tenuta S, Fikrig E, Ryder R. The Emergence of Another Tickborne Infection in the 12-Town Area around Lyme, Connecticut: Human Granulocytic Ehrlichiosis. The Journal Of Infectious Diseases 2000, 181: 1388-1393. PMID: 10751139, DOI: 10.1086/315389.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisTickborne infectionProspective population-based surveillanceGranulocytic ehrlichiosisCommon tickborne infectionPopulation-based surveillancePrimary care providersSubset of seraIndirect fluorescent antibody methodIllness suggestiveCare providersLaboratory evidenceImportant causeProbable casesFluorescent antibody methodImmunoblot assayLyme diseaseInfectionAntibody methodIncidenceEhrlichiosisLymeMorbidityDiseaseSuggestive
1987
Epidemiology of American Cutaneous Leishmaniasis Due to Leishmania braziliensis brasiliensis
Jones T, Johnson W, Barretto A, Lago E, Badaro R, Cerf B, Reed S, Netto E, Tada M, Franca F, Wiese K, Golightly L, Fikrig E, Costa J, Cuba C, Marsden P. Epidemiology of American Cutaneous Leishmaniasis Due to Leishmania braziliensis brasiliensis. The Journal Of Infectious Diseases 1987, 156: 73-83. PMID: 3598227, DOI: 10.1093/infdis/156.1.73.Peer-Reviewed Original ResearchConceptsPrimary lesionMucosal diseaseCutaneous leishmaniasisFive-year prospective studyLeishmania braziliensis braziliensisYears of ageAmerican cutaneous leishmaniasisAntimony therapyAnnual incidenceSkin testingProspective studyRecent lesionsSkin testSkin lesionsEndemic areasPatientsLesionsDiseaseMost diseasesLeishmaniasisYearsTherapyEpidemiologyPrevalenceIncidence