Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension
Alenezi F, Mandawat A, Il'Giovine ZJ, Shaw LK, Siddiqui I, Tapson VF, Arges K, Rivera D, Romano MMD, Velazquez EJ, Douglas PS, Samad Z, Rajagopal S. Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension. Circulation Cardiovascular Imaging 2018, 11: e006984. PMID: 30571314, PMCID: PMC6309911, DOI: 10.1161/circimaging.117.006984.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionArterial hypertensionRA dysfunctionLongitudinal strainComplete echocardiographic dataResults Study subjectsRight atrial functionRight atrial enlargementComposite of timeEarly diastolic SRPeak longitudinal strainRA conduitRA reservoirMultivariable adjustmentPulmonary hypertensionAtrial functionComposite outcomeDiastolic SRAtrial enlargementAtrial sizePrimary outcomePrognostic importancePrognostic valueAdverse outcomesMean ageDiastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study
Butler J, Kalogeropoulos AP, Anstrom KJ, Hsue PY, Kim RJ, Scherzer R, Shah SJ, Shah SH, Velazquez EJ, Hernandez AF, Desvigne-Nickens P, Braunwald E. Diastolic Dysfunction in Individuals With Human Immunodeficiency Virus Infection: Literature Review, Rationale and Design of the Characterizing Heart Function on Antiretroviral Therapy (CHART) Study. Journal Of Cardiac Failure 2018, 24: 255-265. PMID: 29482027, PMCID: PMC5880702, DOI: 10.1016/j.cardfail.2018.02.001.Peer-Reviewed Original ResearchConceptsDiastolic dysfunctionAntiretroviral Therapy studyAntiretroviral therapyMyocardial fibrosisHeart functionMyocardial stressHuman immunodeficiency virus (HIV) infectionAge-matched control subjectsTherapy studiesLV diastolic dysfunctionVentricular systolic dysfunctionImmunodeficiency virus infectionCardiac magnetic resonance examinationHuman immunodeficiency virusMarkers of fibrosisImmune system activationSubclinical myocardial necrosisMagnetic resonance examinationOngoing inflammationSystolic dysfunctionAtrial functionCardiac involvementSystemic inflammationHIV individualsMyocardial effects