2024
Addition of rapamycin or co-culture with cumulus cells from younger reproductive age women does not improve rescue in vitro oocyte maturation or euploidy rates in older reproductive age women
Esbert M, Tao X, Ballesteros A, Yildirim R, Scott R, Seli E. Addition of rapamycin or co-culture with cumulus cells from younger reproductive age women does not improve rescue in vitro oocyte maturation or euploidy rates in older reproductive age women. Molecular Human Reproduction 2024, 30: gaad048. PMID: 38180884, DOI: 10.1093/molehr/gaad048.Peer-Reviewed Original ResearchReproductive-age womenEuploidy rateCumulus cellsAutologous cumulus cellsAge womenReproductive ageRescue IVMOlder womenYoung donorsYoung reproductive age womenYoung womenOlder reproductive age womenOocyte maturationMetaphase II oocytesGerminal vesicle stage oocytesPolar bodyMaternal ageEuploid oocytesFirst polar bodyAddition of rapamycinHours of cultureII oocytesWomenCytogenetic constitutionRapamycin
2022
Distress response in granulosa cells of women affected by PCOS with or without insulin resistance
Cozzolino M, Herraiz S, Cakiroglu Y, Garcia-Velasco JA, Tiras B, Pacheco A, Rabadan S, Kohls G, Barrio AI, Pellicer A, Seli E. Distress response in granulosa cells of women affected by PCOS with or without insulin resistance. Endocrine 2022, 79: 200-207. PMID: 36149529, DOI: 10.1007/s12020-022-03192-8.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeHomeostasis model assessmentPCOS-IRInsulin resistanceHealthy oocyte donorsCumulus GCsOvarian syndromePCOS groupPlasma glucoseCONT groupMetabolic dysfunctionPathological changesFollicular microenvironmentConclusionOur findingsOocyte donorsGranulosa cellsModel assessmentQRT-PCRWomenER stressCONTMolecular mechanismsCell stressDistress responsesGroup
2021
Emerging follicular activation strategies to treat women with poor ovarian response and primary ovarian insufficiency
Reig A, Herraiz S, Pellicer A, Seli E. Emerging follicular activation strategies to treat women with poor ovarian response and primary ovarian insufficiency. Current Opinion In Obstetrics & Gynecology 2021, 33: 241-248. PMID: 33896920, DOI: 10.1097/gco.0000000000000703.Peer-Reviewed Original ResearchConceptsPoor ovarian responsePrimary ovarian insufficiencyLive birthsOngoing pregnancyOvarian responseOvarian insufficiencyAutologous platelet-rich plasmaBone marrow transplantFemale reproductive agingPlatelet-rich plasmaIntraovarian injectionOvarian transplantationMarrow transplantReproductive agingFertility treatmentReproductive medicineWomenPregnancyBirthInsufficiencyPrevious reportsPreliminary studyMechanical disruptionAkt stimulationCutting-edge strategiesNoninvasive prenatal testing in women undergoing in vitro fertilization with preimplantation genetic testing
Klimczak AM, Seli E, Scott RT. Noninvasive prenatal testing in women undergoing in vitro fertilization with preimplantation genetic testing. Current Opinion In Obstetrics & Gynecology 2021, 33: 184-187. PMID: 33797422, DOI: 10.1097/gco.0000000000000707.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingGenetic testingNoninvasive prenatal testing resultsPositive test resultsPrenatal screening toolPositive predictive valuePrenatal testing resultsPregnant womenEuploid embryosPredictive valueNoninvasive prenatal testingScreening toolWomenRecent evidenceIVFPrenatal testingPGTPregnancyPrevalencePrenatalTestingAnalysis of female demographics in the United States: life expectancy, education, employment, family building decisions, and fertility service utilization
Esencan E, Simsek B, Seli E. Analysis of female demographics in the United States: life expectancy, education, employment, family building decisions, and fertility service utilization. Current Opinion In Obstetrics & Gynecology 2021, 33: 170-177. PMID: 33797423, DOI: 10.1097/gco.0000000000000704.Peer-Reviewed Original ResearchConceptsReproductive technology treatmentMedian agePregnancy attemptsART cyclesMean ageService utilizationPregnancy rateFemale fertility ratesFamily-building decisionsFertility servicesFraction of womenTechnology treatmentDonor eggsFertility rateFirst birthWomenLife expectancyAgeFemale demographicDiagnosisMarried women
2020
Mitochondrial function in women with polycystic ovary syndrome.
Cozzolino M, Seli E. Mitochondrial function in women with polycystic ovary syndrome. Current Opinion In Obstetrics & Gynecology 2020, 32: 205-212. PMID: 32068544, DOI: 10.1097/gco.0000000000000619.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeLower mtDNA copy numberOvary syndromePathogenesis of PCOSMitochondrial dysfunctionMtDNA copy numberPotential protective rolePCOS phenotypeInsulin resistancePathophysiological mechanismsCommon findingDiagnostic modalitiesMetabolic milieuFunctional alterationsMitochondrial functional alterationsProtective roleCommon diseaseOxidative stressWomenMitochondrial functionDysfunctionSyndromeCopy numberProtein responseReactive oxygen
2019
Diminished ovarian reserve versus ovarian aging: overlaps and differences.
Ata B, Seyhan A, Seli E. Diminished ovarian reserve versus ovarian aging: overlaps and differences. Current Opinion In Obstetrics & Gynecology 2019, 31: 139-147. PMID: 30870184, DOI: 10.1097/gco.0000000000000536.Peer-Reviewed Original ResearchConceptsNormal ovarian reserveOvarian reservePregnancy lossOocyte qualityReproductive technology cyclesAge-matched womenDiminished ovarian reserveLow ovarian reserveFetal chromosomal abnormalitiesQuantitative declineFecundity of womenOvarian stimulationNatural conceptionOvarian agingPoor responseART treatmentAged womenYoung womenChromosomal abnormalitiesAvailable evidenceDecreased numberQualitative declineOocyte poolWomenBlastocyst development
2018
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation
Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.Peer-Reviewed Original ResearchConceptsChronologic agePremature reproductive agingReproductive-age womenWhite blood cellsOvarian stimulationInfertile womenOvarian responsePatient ageInfertile patientsAge womenPoor responseFollicular somatic cellsReproductive agingFertility treatmentCumulus cellsBlood cellsTelomere lengthAgeWomenPatientsStimulationWBCFemale ageRiskReproductive senescenceAssisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications
Morin SJ, Seli E. Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications. Seminars In Reproductive Medicine 2018, 36: 195-203. PMID: 30866006, DOI: 10.1055/s-0038-1677048.Peer-Reviewed Original ResearchConceptsSevere male factor infertilityART-exposed childrenLow birth weightMale factor infertilityReproductive technologiesSevere monogenic disordersAssisted Reproductive TechnologyMultiple gestationsSubfertile womenFactor infertilityMetabolic derangementsPremature birthAbsolute riskBirth weightCardiovascular diseaseAdditional diagnosisNumber of womenClinical realityMultiple studiesMonogenic disordersNumber of couplesRiskOrigin of diseaseDiseaseWomenThe role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights
Cecchino GN, Seli E, Alves da Motta E, García-Velasco J. The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights. Reproductive BioMedicine Online 2018, 36: 686-697. PMID: 29598846, DOI: 10.1016/j.rbmo.2018.02.007.Peer-Reviewed Original ResearchConceptsMetabolic stress modelsMitochondrial functionFemale fertilityFemale reproductive processesPoor outcomeReplacement therapyOvarian agingMitochondrial DNA contentInfertility treatmentTherapeutic attemptsOocyte qualityClinical implicationsEmbryo potentialOocyte maturationReproductive processesPrecursor cellsEarly embryo developmentReproductive technologiesDisease-causing mutationsMitochondrial capacityRole of mitochondriaMitochondrial impactCurrent insightsTrophectoderm cellsWomen
2016
Same-sex reproduction
Greenfeld DA, Seli E. Same-sex reproduction. Current Opinion In Obstetrics & Gynecology 2016, 28: 202-205. PMID: 27077473, DOI: 10.1097/gco.0000000000000266.Peer-Reviewed Original ResearchConceptsSame-sex couplesSame-sex reproductionGay menPublic acceptanceSame-sex marriageSame-sex relationshipsSame-sex unionsHeterosexual parentsGay couplesHeterosexual couplesParenthoodHistorical significanceGreat endeavorNumber of menFertility treatment centreAssisted reproductionLesbiansGayWomenMarriageUnionAcceptanceRelationship satisfactionCouplesPositive functioning
2015
Oocyte Cryopreservation as a Preventive Measure for Age-Related Fertility Loss
Cil AP, Turkgeldi L, Seli E. Oocyte Cryopreservation as a Preventive Measure for Age-Related Fertility Loss. Seminars In Reproductive Medicine 2015, 33: 429-435. PMID: 26562287, DOI: 10.1055/s-0035-1567819.Peer-Reviewed Original ResearchConceptsAge-related declineOocyte cryopreservationAge-related fertility lossGood ovarian reserveFertility preservation strategiesPublic health campaignsPreconceptional counselingOvarian reserveAdvanced ageHealth campaignsPreventive measuresHealth informationMedical professionalsLater stagesWomenYoung adolescentsPreservation strategiesPatientsFertility lossIncidencePublic awareness
2010
Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH
Gerasimova T, Thanasoula MN, Zattas D, Seli E, Sakkas D, Lalioti MD. Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 529-536. PMID: 20061434, PMCID: PMC2840851, DOI: 10.1210/jc.2009-1304.Peer-Reviewed Original ResearchConceptsOvarian responseFSH receptorFSHR mRNAAbnormal ovarian responseOvarian stimulation protocolsForms of infertilityOocytes of womenExtracellular ligand-binding portionHormone receptor variantsOvarian hyperstimulationOvarian stimulationFSHR variantsPoor responseInfertility treatmentT cellsStimulation protocolFollicle growthFSHFertility clinicsCAMP activationCumulus cellsReceptor variantsGenetic causeRT-PCRWomen
2009
Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer
Seli E, Vergouw CG, Morita H, Botros L, Roos P, Lambalk CB, Yamashita N, Kato O, Sakkas D. Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertility And Sterility 2009, 94: 535-542. PMID: 19589524, DOI: 10.1016/j.fertnstert.2009.03.078.Peer-Reviewed Original ResearchConceptsSingle embryo transferDay 3 embryosDay 2Embryo transferImplantation rateEmbryo culture mediumMetabolomic profilingPositive fetal cardiac activityAssisted reproductive technology programViability indexNoninvasive metabolomic profilingFetal cardiac activityReproductive technology programHuman embryo culture mediaRetrospective studyMAIN OUTCOMEDay 3Morphology gradeBlinded analysisCardiac activityReproductive potentialEmbryo assessmentCulture mediumBlinded validationWomen
2004
Treatment of PCOS with metformin and other insulin-sensitizing agents
Seli E, Duleba AJ. Treatment of PCOS with metformin and other insulin-sensitizing agents. Current Diabetes Reports 2004, 4: 69-75. PMID: 14764283, DOI: 10.1007/s11892-004-0014-8.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeInsulin-sensitizing agentsSerum insulinInsulin resistanceTreatment of PCOSType 2 diabetes mellitusElevated serum insulinUse of metforminTreatment of womenOvary syndromeCompensatory hyperinsulinemiaDiabetes mellitusOvulatory functionD-chiro-inositolAndrogen levelsCardiovascular disordersMetforminHyperinsulinemiaWomenSignificant proportionTreatmentInsulinAgentsHyperandrogenismAnovulation
1998
Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells.
Bahtiyar MO, Seli E, Oral E, Senturk LM, Zreik TG, Arici A. Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells. Human Reproduction 1998, 13: 3492-3495. PMID: 9886538, DOI: 10.1093/humrep/13.12.3492.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsFollicular fluidPeritoneal fluidEndometrial cellsCell proliferationStromal cellsEndometrial stromal cell culturesFollicular fluid contentEndometrial cell proliferationOocyte retrievalStromal cell culturesPeritoneal environmentCell proliferation assaysEndometriosisGrowth-promoting factorsGrowth-promoting effectProliferation assaysWomenMaximum cell proliferationProliferationCellsCell culturesHigher cell proliferationFluid content