2020
Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts
Yang M, Tao X, Titus S, Zhao T, Scott RT, Seli E. Analysis of accessible chromatin landscape in the inner cell mass and trophectoderm of human blastocysts. Molecular Human Reproduction 2020, 26: 702-711. PMID: 32663300, DOI: 10.1093/molehr/gaaa048.Peer-Reviewed Original ResearchConceptsInner cell massHuman preimplantation embryosEpigenetic regulationPreimplantation embryosCell lineage specificationChromatin accessibility landscapeAccessible chromatin landscapePreimplantation human blastocystsEarly embryonic developmentTranscription start siteCell massEarly embryo developmentHuman blastocystsDistal regionChromatin landscapeAccessible chromatinLineage specificationChromatin structureLow DNA inputATAC-seqTrophectoderm differentiationChromosome reorganizationAccessibility landscapeHuman embryonic materialEmbryonic development
2019
Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging
Seli E, Wang T, Horvath TL. Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertility And Sterility 2019, 111: 197-204. PMID: 30691623, DOI: 10.1016/j.fertnstert.2018.11.048.Peer-Reviewed Original ResearchConceptsMitochondrial unfolded protein responseTwo-cell embryo developmentUnfolded protein responseImpaired oocyte maturationMorphology of mitochondriaMitochondrial dysfunction resultsPremature reproductive agingNovel mechanistic insightsMitochondrial DNA contentReactive oxygen species productionPrevention of agingCLPP resultsProtein responseOxygen species productionReproductive agingPreimplantation embryosAge-related accumulationOxidative phosphorylationStress responseEmbryo developmentForm blastocystsMitochondrial functionMitochondriaMitochondrial dysfunctionEnergy metabolism
2018
Metabolism of the oocyte and the preimplantation embryo
Scott R, Zhang M, Seli E. Metabolism of the oocyte and the preimplantation embryo. Current Opinion In Obstetrics & Gynecology 2018, 30: 163-170. PMID: 29708901, DOI: 10.1097/gco.0000000000000455.Peer-Reviewed Original Research
2008
Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte
Seli E, Yaba A, Guzeloglu-Kayisli O, Lalioti MD. Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte. Molecular Human Reproduction 2008, 14: 393-398. PMID: 18492745, PMCID: PMC2453241, DOI: 10.1093/molehr/gan028.Peer-Reviewed Original ResearchConceptsExonic splicing enhancersAlternative splicing variantsSingle nucleotide polymorphismsAlternative splicingSplicing variantsSplicing enhancersExon 10Post-transcriptional controlMRNA alternative splicingEarly preimplantation embryosOocyte-specific proteinRNA editingMaternal mRNAsEarly embryosMouse embryonicBinding protein mRNAReal-time RT-PCR resultsGene expressionPreimplantation embryosSpliced formsSame locusSequence analysisBinding proteinSplicingParental origin
2005
An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos
Seli E, Lalioti MD, Flaherty SM, Sakkas D, Terzi N, Steitz JA. An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 367-372. PMID: 15630085, PMCID: PMC544294, DOI: 10.1073/pnas.0408378102.Peer-Reviewed Original ResearchConceptsZygotic gene activationGene activationEarly embryosSomatic cellsTranslational activationGene expressionEmbryo developmentEarly preimplantation embryo developmentEarly Xenopus developmentEarly preimplantation embryosEight-cell stageEarly embryo developmentPreimplantation embryo developmentTwo-cell embryosCytoplasmic PABPMouse orthologXenopus developmentMammalian oocytesProphase ISomatic tissuesChromosome 2Preimplantation embryosEPABMouse oocytesOne-cell