In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis.
Shulman R, Bloch G, Rothman D. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8535-8542. PMID: 7567971, PMCID: PMC41002, DOI: 10.1073/pnas.92.19.8535.Peer-Reviewed Original ResearchMeSH KeywordsAllosteric RegulationAnimalsDiabetes Mellitus, Type 2Gene Expression Regulation, EnzymologicGlucose-6-PhosphateGlucosephosphatesGlycogenGlycogen SynthaseHumansModels, BiologicalMusclesPhosphorylationRatsConceptsCovalent phosphorylationGlycogen synthesisGlycogen synthaseMuscle glycogen synthaseVivo NMR methodsPositive allosteric effectorMetabolic control theoryAllosteric effectorsVivo regulationGSaseVivo NMR experimentsNMR experimentsPhosphorylationSynthesis fluxProximal stepMuscle glycogen synthesisSynthaseVivo NMRRegulationNMR methodsMetabolite levelsHuman muscleRat muscleEffectorsEnzyme