2012
Prostaglandin E2 Affects T Cell Responses through Modulation of CD46 Expression
Kickler K, Maltby K, Choileain S, Stephen J, Wright S, Hafler DA, Jabbour HN, Astier AL. Prostaglandin E2 Affects T Cell Responses through Modulation of CD46 Expression. The Journal Of Immunology 2012, 188: 5303-5310. PMID: 22544928, PMCID: PMC3758685, DOI: 10.4049/jimmunol.1103090.Peer-Reviewed Original ResearchConceptsG protein-coupled receptor kinasesCell functionProtein-coupled receptor kinasesT cell functionT cell activationG protein-coupled receptorsProtein-coupled receptorsCD46 expressionPrimary T cellsReceptor kinaseT cellsCD46 functionsCell activationRegulatory mechanismsDiverse rolesDifferentiation pathwayNovel roleCytokine productionProstanoid familyActivation signalsActivated T cellsT cell responsesChronic inflammatory diseaseSubtypes of receptorsCD46 activationProstaglandin E2 affects T cell responses through modulation of CD46 expression. (178.8)
Astier A, Kickler K, Ni Choileain S, Stephen J, Hafler D, Jabbour H. Prostaglandin E2 affects T cell responses through modulation of CD46 expression. (178.8). The Journal Of Immunology 2012, 188: 178.8-178.8. DOI: 10.4049/jimmunol.188.supp.178.8.Peer-Reviewed Original ResearchT cell functionCell functionReceptor kinase familyT cell activationProstaglandin E2CD46 expressionT cellsPrimary T cellsKinase familyCytokine productionCD46 functionsCell activationRegulatory mechanismsDiverse rolesDifferentiation pathwayNovel roleG proteinsCell surfaceRole of PGE2Addition of PGE2T cell surfaceT cell responsesChronic inflammatory diseaseComplement regulator CD46Activation signals
2008
Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis
Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. Journal Of Neuroimmunology 2008, 195: 140-145. PMID: 18403025, PMCID: PMC2702859, DOI: 10.1016/j.jneuroim.2008.01.002.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCentral nervous systemChemokine productionHealthy donorsCD46 activationPathogenesis of MSIL-23 secretionChronic inflammatory diseasePotent proinflammatory cytokineRole of CD46CCL2 levelsDC activationIL-23Dendritic cellsIL-23p19Proinflammatory cytokinesCCL5 productionInflammatory diseasesNervous systemPatientsPotential roleSclerosisCytokinesActivationElevated amounts
2006
The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus
De Jager PL, Graham R, Farwell L, Sawcer S, Richardson A, Behrens TW, Compston A, Hafler DA, Kere J, Vyse TJ, Rioux JD. The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. Genes & Immunity 2006, 7: 327-334. PMID: 16642031, DOI: 10.1038/sj.gene.6364303.Peer-Reviewed Original ResearchMeSH KeywordsChromosomes, Human, Pair 5ExonsGenetic Predisposition to DiseaseHumansInflammatory Bowel DiseasesIntracellular Signaling Peptides and ProteinsLupus Erythematosus, SystemicMembrane ProteinsMultiple SclerosisNod2 Signaling Adaptor ProteinPolymorphism, Single NucleotideTumor Suppressor ProteinsConceptsSystemic lupus erythematosusInflammatory bowel diseaseMultiple sclerosisRisk allelesLupus erythematosusInflammatory diseasesCases of SLERisk of SLECARD15/NOD2 geneGeneral susceptibility locusIBD risk allelesChronic inflammatory diseaseIBD5 locusComplex inflammatory diseaseInflammatory bowel disease susceptibility lociEvidence of associationLupus nephritisBowel diseaseSLE subjectsPooled analysisCARD15 geneSusceptibility lociNOD2 geneDiseaseErythematosus
2005
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis
De Jager PL, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, Langelier D, Bitton A, Compston A, Hafler DA, Rioux JD. Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis. European Journal Of Human Genetics 2005, 14: 317-321. PMID: 16391555, DOI: 10.1038/sj.ejhg.5201548.Peer-Reviewed Original ResearchMeSH KeywordsAllelesCanadaCase-Control StudiesCrohn DiseaseGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansInflammationModels, StatisticalMultiple SclerosisOdds RatioPolymorphism, GeneticProtein Tyrosine Phosphatase, Non-Receptor Type 1Protein Tyrosine Phosphatase, Non-Receptor Type 22Protein Tyrosine PhosphatasesRiskUnited KingdomConceptsSystemic lupus erythematosusCases of CDCrohn's diseaseMultiple sclerosisPTPN22 620W alleleAutoimmune thyroiditisRheumatoid arthritisInflammatory diseasesEvidence of associationCases of MSProtein tyrosine phosphatase PTPN22Chronic inflammatory diseaseType 1 diabetesTyrosine phosphatase PTPN22PTPN22 alleleLupus erythematosusPooled analysisControl subjectsModest odds ratiosOdds ratioDiseaseRisk allelesPhosphatase PTPN22SclerosisPossible role
1997
Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand
Balashov K, Smith D, Khoury S, Hafler D, Weiner H. Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 599-603. PMID: 9012830, PMCID: PMC19559, DOI: 10.1073/pnas.94.2.599.Peer-Reviewed Original ResearchConceptsIL-12 secretionIFN-gamma secretionMS patientsMultiple sclerosisT cellsIL-12Anti-CD40 ligand antibodyTh1-type immune activationCell-mediated autoimmune diseaseProgressive MS patientsProgressive multiple sclerosisIFN-gamma administrationRelapsing-remitting patientsExacerbation of diseaseInterleukin-12 productionChronic inflammatory diseaseCD40 ligand expressionCentral nervous systemActivated T cellsImmune interventionImmune activationAutoimmune diseasesInterleukin-12Inflammatory diseasesCD40 ligand
1992
T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.
Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. Journal Of Experimental Medicine 1992, 175: 993-1002. PMID: 1348083, PMCID: PMC2119186, DOI: 10.1084/jem.175.4.993.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAntigens, Differentiation, T-LymphocyteBase SequenceCD2 AntigensChronic DiseaseClone CellsCytokinesGene ExpressionHumansInterleukin-1Interleukin-2Interleukin-4Molecular Sequence DataMultiple SclerosisOligodeoxyribonucleotidesPolymerase Chain ReactionReceptors, Antigen, T-Cell, alpha-betaReceptors, ImmunologicRNA, MessengerConceptsTCR V alphaTCR repertoireBeta repertoireMultiple sclerosisV alphaActive lesionsMS plaquesT cellsAlpha/beta T cellsActive multiple sclerosis lesionsMS plaque tissueCentral nervous system tissueT cell recruitmentBeta T cellsActive MS plaquesChronic inflammatory diseaseIL-4 mRNAT cell expansionIL-1 mRNATCR V gene segmentsCentral nervous systemCases of subacuteNervous system tissueSites of inflammationTCR V genesT-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones.
Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D, Hafler DA. T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 2110-2114. PMID: 1549569, PMCID: PMC48606, DOI: 10.1073/pnas.89.6.2110.Peer-Reviewed Original ResearchConceptsIntercellular cell adhesion moleculeBlood T cellsT cell clonesT cell activationIL-2 receptorT cellsActivated T cellsHuman T-cell leukemia virus type I (HTLV-I) carriersSuch activated T cellsHAM/TSP patientsMyelopathy/tropical spastic paraparesisClass II major histocompatibility complex moleculesHAM/TSPChronic inflammatory diseaseExogenous interleukin-2HTLV-I infectionTropical spastic paraparesisMajor histocompatibility complex moleculesHuman T-cell leukemia virus type IVirus type IHistocompatibility complex moleculesCD2/LFATSP patientsSpastic paraparesisSpontaneous proliferationAutoreactive T Cells in Multiple Sclerosis
Zhang J, Weiner H, Hafler D. Autoreactive T Cells in Multiple Sclerosis. International Reviews Of Immunology 1992, 9: 183-201. PMID: 1285060, DOI: 10.3109/08830189209061790.Peer-Reviewed Original ResearchConceptsCentral nervous systemMultiple sclerosisInflammatory processT cellsCerebrospinal fluidNervous systemAcute MS plaquesActive inflammatory processAutoreactive T cellsChronic inflammatory diseaseCNS inflammatory processesIL-2 receptorPeripheral nervous systemActivated T cellsNeurologic disabilityNeurological functionMS plaquesSensory deficitsInflammatory diseasesOligoclonal immunoglobulinsPositive macrophagesT lymphocytesWhite matterVisual problemsDemyelination
1991
T-cell recognition of myelin basic protein
Wucherpfennig K, Weiner H, Hafler D. T-cell recognition of myelin basic protein. Trends In Immunology 1991, 12: 277-282. PMID: 1716903, DOI: 10.1016/0167-5699(91)90126-e.Peer-Reviewed Original ResearchConceptsChronic inflammatory diseaseCentral nervous systemT cell recognitionMyelin basic proteinMultiple sclerosisInflammatory diseasesNervous systemBasic proteinSclerosisDisease