2013
From epoxomicin to carfilzomib : chemistry, biology, and medical outcomes
Kim KB, Crews CM. From epoxomicin to carfilzomib : chemistry, biology, and medical outcomes. Natural Product Reports 2013, 30: 600-604. PMID: 23575525, PMCID: PMC3815659, DOI: 10.1039/c3np20126k.Peer-Reviewed Original ResearchConceptsActive natural productsNatural productsNatural product-based drug discoveryAnti-tumor natural productParent lead compoundRational drug designUnprecedented selectivityHigh-throughput screeningPeptide structureMolecular probesImproved activityDrug designLead compoundsDrug discoveryPharmacophoreEpoxyketonesChemistryProductsSelectivityCompoundsTherapeutic agentsBiological processesDiscoveryScaffoldsBristol-Myers Squibb
2012
Exploring Biology with Small Organic Molecules
Aberle N, Crews C. Exploring Biology with Small Organic Molecules. 2012, 10-25. DOI: 10.1017/cbo9781139021500.004.Peer-Reviewed Original ResearchChemical geneticsSmall moleculesSmall organic moleculesFundamental biological processesProtein of interestGood target specificityOrganic moleculesSemisynthetic moleculesChemical genomicsBiological processesTarget specificityMoleculesGeneticsBiologyVast arrayActive ingredientsChemistryGenomicsCertain basic elementsHuman medicineTherapeuticsCompoundsPlantsProteinPhenotype
2006
Construction of Highly Substituted Stereodefined Dienes by Cross‐Coupling of α‐Allenic Acetates
Schneekloth J, Pucheault M, Crews C. Construction of Highly Substituted Stereodefined Dienes by Cross‐Coupling of α‐Allenic Acetates. European Journal Of Organic Chemistry 2006, 2007: 40-43. DOI: 10.1002/ejoc.200600721.Peer-Reviewed Original ResearchNatural product chemistryStraightforward reaction conditionsOrganic chemistryProduct chemistryOrganozinc reagentsSubstrate scopeReaction conditionsPalladium precatalystsHigh selectivityZ selectivityCross couplingSelectivityChemistryReactionLigandsDieneInteresting reversalPrecatalystOlefinsReagentsProductsAcetateAssemblyBroad useAppropriate choiceProbing Protein Function with Small Molecules
Gough JD, Crews CM. Probing Protein Function with Small Molecules. Ernst Schering Foundation Symposium Proceedings 2006, 58: 61-74. PMID: 16708999, DOI: 10.1007/978-3-540-37635-4_5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiotinylationCombinatorial Chemistry TechniquesDrug DesignDrug Evaluation, PreclinicalGenomicsGreen Fluorescent ProteinsHumansKetonesModels, ChemicalMolecular Probe TechniquesNanotechnologyOligopeptidesPhosphorylationProtein BindingProteinsReceptors, AndrogenRecombinant Fusion ProteinsSerineSesquiterpenesSignal TransductionUbiquitin-Protein Ligases
1996
Deciphering isozyme function: exploring cell biology with chemistry in the post-genomic era
Crews C. Deciphering isozyme function: exploring cell biology with chemistry in the post-genomic era. Cell Chemical Biology 1996, 3: 961-965. PMID: 9000005, DOI: 10.1016/s1074-5521(96)90162-3.Peer-Reviewed Original Research