2001
Clozapine in the treatment of aggression in an adolescent with autistic disorder.
Chen N, Bedair H, McKay B, Bowers M, Mazure C. Clozapine in the treatment of aggression in an adolescent with autistic disorder. The Journal Of Clinical Psychiatry 2001, 62: 479-80. PMID: 11465533, DOI: 10.4088/jcp.v62n0612h.Peer-Reviewed Original Research
1999
Olanzapine for Treatment-Refractory Psychosis in Patients Responsive to, but Intolerant of, Clozapine
Weiss E, Longhurst J, Bowers M, Mazure C. Olanzapine for Treatment-Refractory Psychosis in Patients Responsive to, but Intolerant of, Clozapine. Journal Of Clinical Psychopharmacology 1999, 19: 378-380.. PMID: 10440469, DOI: 10.1097/00004714-199908000-00017.Peer-Reviewed Original ResearchDrug-Responsive Mania in a Man With a Brain Tumor
Mazure C, Leibowitz K, Bowers M. Drug-Responsive Mania in a Man With a Brain Tumor. Journal Of Neuropsychiatry 1999, 11: 114-115. PMID: 9990567, DOI: 10.1176/jnp.11.1.114.Peer-Reviewed Original Research
1998
Pretreatment plasma HVA predicts neuroleptic response in manic psychosis
Mazure C, Bowers M. Pretreatment plasma HVA predicts neuroleptic response in manic psychosis. Journal Of Affective Disorders 1998, 48: 83-86. PMID: 9495606, DOI: 10.1016/s0165-0327(97)00159-6.Peer-Reviewed Original ResearchAcute Neuroleptic Treatment in Elderly Patients Without Dementia
Mazure C, Nelson J, Jatlow P, Bowers M. Acute Neuroleptic Treatment in Elderly Patients Without Dementia. American Journal Of Geriatric Psychiatry 1998, 6: 221-229. PMID: 9659955, DOI: 10.1097/00019442-199800630-00005.Peer-Reviewed Original ResearchConceptsNon-elderly adultsElderly patientsNeuroleptic treatmentAcute responseLow dosesLow-dose neuroleptic treatmentAcute neuroleptic treatmentAdverse effectsHigh-dose treatmentLow-dose treatmentDrug blood levelsPrimary psychotic illnessInitial doseBlood levelsPsychotic illnessEffective treatmentPatientsDose ratioLonger durationTreatmentLower ratesDosesAdultsResponseNeurolepticsManagement of the Adverse Effects of Clozapine
Young CR, Bowers MB, Mazure CM. Management of the Adverse Effects of Clozapine. Schizophrenia Bulletin 1998, 24: 381-390. PMID: 9718630, DOI: 10.1093/oxfordjournals.schbul.a033333.Peer-Reviewed Original ResearchConceptsAdverse effectsElevated liver enzymesPercent of patientsSuccessful pharmacological managementPositive therapeutic outcomesHypothesized pathophysiologyPharmacological managementRefractory schizophreniaNeuromuscular effectsTraditional neurolepticsLiver enzymesPharmacological interventionsClozapineAffective disordersTherapeutic outcomesNeurological disordersMental disordersMaximum doseObsessive-compulsive symptomsWeight gainDisordersPatientsPathophysiologyNew hopeTreatment
1997
The Expanding Indications for Clozapine
Young C, Longhurst J, Bowers M, Mazure C. The Expanding Indications for Clozapine. Experimental And Clinical Psychopharmacology 1997, 5: 216-234. PMID: 9260069, DOI: 10.1037/1064-1297.5.3.216.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsClozapineHumansMood DisordersNervous System DiseasesSchizophreniaConceptsUnique pharmacodynamic profileUse of clozapineTreatment-resistant schizophreniaTraditional drug treatmentExpanding IndicationsClozapine treatmentNeurologic conditionsPharmacodynamic profileClinical indicationsDrug treatmentMood disordersEffective treatmentClozapineSubstance abuseChildhood schizophreniaRelevant literatureSchizophreniaDisordersTreatmentAggressive behaviorIndicationsInitial rationaleAgranulocytosisPatientsBody of literatureChronic neuroleptic exposure in bipolar outpatients.
Sernyak MJ, Godleski LS, Griffin RA, Mazure CM, Woods SW. Chronic neuroleptic exposure in bipolar outpatients. The Journal Of Clinical Psychiatry 1997, 58: 193-5. PMID: 9184612, DOI: 10.4088/jcp.v58n0503.Peer-Reviewed Original ResearchConceptsChronic neuroleptic exposureNeuroleptic exposureBipolar outpatientsBipolar disorderConnecticut Mental Health CenterChronic neuroleptic administrationMental health centersComputerized administrative databasesNeuroleptic medicationChlorpromazine equivalentsNeuroleptic administrationChronic useMedical recordsAdministrative databasesNeuroleptic dosageHealth centersBipolar patientsPatientsOutpatientsReview criteriaDisordersExposurePast yearMedicationsDiagnosisRecent life stressors and biological markers in newly admitted psychotic patients
Mazure C, Quinlan D, Bowers M. Recent life stressors and biological markers in newly admitted psychotic patients. Biological Psychiatry 1997, 41: 865-870. PMID: 9099413, DOI: 10.1016/s0006-3223(96)00222-3.Peer-Reviewed Original Research
1995
Developmental and Biologic Correlates of Early Neuroleptic Response
Bowers M, Mazure C, Glick M, Zigler E. Developmental and Biologic Correlates of Early Neuroleptic Response. Journal Of Clinical Psychopharmacology 1995, 15: 224-225.. PMID: 7636003, DOI: 10.1097/00004714-199506000-00014.Peer-Reviewed Original ResearchAssessment of extrapyramidal symptoms during acute neuroleptic treatment.
Mazure CM, Cellar JS, Bowers MB, Nelson JC, Takeshita J, Zigun B. Assessment of extrapyramidal symptoms during acute neuroleptic treatment. The Journal Of Clinical Psychiatry 1995, 56: 94-100. PMID: 7883736.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAkathisia, Drug-InducedAntipsychotic AgentsBasal Ganglia DiseasesDystoniaFemaleHumansMaleMiddle AgedParkinson Disease, SecondaryPhysical ExaminationPsychiatric Status Rating ScalesPsychotic DisordersReproducibility of ResultsSeverity of Illness IndexStatistics, NonparametricConceptsExtrapyramidal symptomsDrug regimenAcute treatmentNeuroleptic drugsSide effectsInterrater reliabilityAcute neuroleptic treatmentPatient's drug regimenExtrapyramidal Symptoms ScaleExtrapyramidal side effectsTraditional neuroleptic drugsLow nonsignificant correlationsRatings of symptomsAcute administrationNeuroleptic treatmentAdverse reactionsParkinson's diseasePsychotic symptomsSymptom ScalePsychotic patientsEPS scaleSymptomsClinician ratersCliniciansInterrater agreement
1993
Premorbid social competence and the effectiveness of early neuroleptic treatment
Glick M, Mazure C, Bowers M, Zigler E. Premorbid social competence and the effectiveness of early neuroleptic treatment. Comprehensive Psychiatry 1993, 34: 396-401. PMID: 7907536, DOI: 10.1016/0010-440x(93)90064-b.Peer-Reviewed Original Research
1990
Psychotogenic Drug Use and Neuroleptic Response
Bowers MB, Mazure CM, Nelson JC, Jatlow PI. Psychotogenic Drug Use and Neuroleptic Response. Schizophrenia Bulletin 1990, 16: 81-85. PMID: 1970670, DOI: 10.1093/schbul/16.1.81.Peer-Reviewed Original ResearchConceptsDrug useNeuroleptic responseDual diagnosis patientsDoses of haloperidolPsychotic malesDevelopment of psychosisPsychotogenic drugsDiagnosis patientsDopaminergic mechanismsPrior historyPsychotic disordersMeans of effectsRefractorinessSeparate studiesMalesEarly stagesHaloperidolPatientsIllnessPsychosisDoses