2016
β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
Holmes SE, Esterlis I, Mazure CM, Lim YY, Ames D, Rainey-Smith S, Martins RN, Salvado O, Dore V, Villemagne VL, Rowe CC, Laws SM, Masters CL, Maruff P, Pietrzak RH, Australian Imaging B. β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal Of Geriatric Psychiatry 2016, 24: 1191-1195. PMID: 27742526, DOI: 10.1016/j.jagp.2016.08.007.Peer-Reviewed Original ResearchConceptsBDNF genotypeNormal older womenAnxiety symptomsOlder adultsΕ4 carriageOlder womenDepressive symptomsΒ-amyloidGreater severityAustralian Imaging BiomarkersNon-ε4 carriersSeverity of depressiveMet allele carriersSeverity of anxietyGreater depressive symptomsNormal older adultsGreater anxiety symptomsLifestyle StudyΕ4 carriersAPOE genotypeAllele carriersAnalysis of covarianceImaging biomarkersSymptomsDepressive
1989
Depression in late life: age of onset as marker of a subtype
Conwell Y, Nelson J, Kim K, Mazure C. Depression in late life: age of onset as marker of a subtype. Journal Of Affective Disorders 1989, 17: 189-195. PMID: 2527894, DOI: 10.1016/0165-0327(89)90042-6.Peer-Reviewed Original ResearchConceptsAge of onsetLate-onset depressionElderly depressivesEarly-onset illnessLonger hospital stayRecurrent affective disordersDistinct pathological processesMore residual symptomsUnipolar major depressivesPresence of psychosisHospital stayClinical featuresMedical illnessResidual symptomsAffective illnessFamily historyLower incidenceMajor depressiveAffective disordersSymptom severityIllnessPathological processesDepressiveLater lifeAge