2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionBinge-Eating Disorder Interventions: Review, Current Status, and Implications
Grilo C, Juarascio A. Binge-Eating Disorder Interventions: Review, Current Status, and Implications. Current Obesity Reports 2023, 12: 406-416. PMID: 37439970, PMCID: PMC10528223, DOI: 10.1007/s13679-023-00517-0.Peer-Reviewed Original ResearchConceptsPsychological treatmentSpecific psychological treatmentsEating-disorder psychopathologyEvidence-based treatmentsAdditional pharmacological optionsDisorder interventionsSerious psychiatric problemsBehavioral lifestyle interventionScalable interventionsEffective interventionsFuture researchCBTPsychiatric problemsBingeMixed outcomesInterventionCBTgshModest weight lossRecent findingsResearchPsychopathologyShameLifestyle interventionPharmacological optionsSubstantial morbidityNaltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlaceboCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapyPredictors and significance of rapid response to behaviorally based treatment of binge eating disorder
Yurkow S, Ivezaj V, Grilo C. Predictors and significance of rapid response to behaviorally based treatment of binge eating disorder. Obesity 2023, 31: 390-398. PMID: 36623872, PMCID: PMC9877118, DOI: 10.1002/oby.23648.Peer-Reviewed Original ResearchConceptsDemographic featuresTreatment attitudesWeight lossFourth treatment weekWeight loss outcomesPsychiatric variablesSuperior clinical outcomesWeight loss treatmentTreatment of bingeClinical severity variablesClinical outcomesPrognostic significanceTreatment weekClinical trialsBaseline predictorsLoss outcomesLoss treatmentPosttreatment outcomesBinge eatingIndependent assessorsBingeSeverity variablesDisordersPatientsTreatment
2016
Binge abstinence is associated with reduced energy intake after treatment in patients with binge eating disorder and obesity
Masheb RM, Dorflinger LM, Rolls BJ, Mitchell DC, Grilo CM. Binge abstinence is associated with reduced energy intake after treatment in patients with binge eating disorder and obesity. Obesity 2016, 24: 2491-2496. PMID: 27797154, PMCID: PMC5172456, DOI: 10.1002/oby.21664.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPsychological functioningBinge abstinencePsychological outcomesCombination of CBTBehavioral therapyBingeRecall interviewsFunctioningAbstinence ratesDietary recall interviewsReduced energy intakeAbstinenceSignificant reductionWeight statusPsychiatric morbidityGreater improvementAdult patientsDietary counselingFruit intakeSugar intakeEnergy intakeDisordersAbstinentComplete cessationPreferred descriptions for loss of control while eating and weight among patients with binge eating disorder
Roberto CA, Galbraith K, Lydecker JA, Ivezaj V, Barnes RD, White MA, Grilo CM. Preferred descriptions for loss of control while eating and weight among patients with binge eating disorder. Psychiatry Research 2016, 246: 548-553. PMID: 27821368, PMCID: PMC5161684, DOI: 10.1016/j.psychres.2016.09.045.Peer-Reviewed Original ResearchFood Thought Suppression Inventory: Test–retest reliability and relationship to weight loss treatment outcomes
Barnes RD, Ivezaj V, Grilo CM. Food Thought Suppression Inventory: Test–retest reliability and relationship to weight loss treatment outcomes. Eating Behaviors 2016, 22: 93-95. PMID: 27112114, PMCID: PMC5161461, DOI: 10.1016/j.eatbeh.2016.04.001.Peer-Reviewed Original ResearchConceptsFood Thought Suppression InventoryWeight loss treatmentBinge-eating episodesTest-retest reliabilityLoss treatmentWeight loss treatment outcomesWeight lossWeight loss goalsOriginal body weightWeek test-retest reliabilityPercent weight lossPrimary careTreatment outcomesIntra-class correlationBody weightBaselineTreatmentScoresEpisodesParticipantsPost assessmentHigh levelsBinge
2015
Evaluation of the DSM-5 severity indicator for bulimia nervosa
Grilo CM, Ivezaj V, White MA. Evaluation of the DSM-5 severity indicator for bulimia nervosa. Behaviour Research And Therapy 2015, 67: 41-44. PMID: 25744910, PMCID: PMC4361239, DOI: 10.1016/j.brat.2015.02.002.Peer-Reviewed Original Research
2014
Comparing weight gain in the year prior to treatment for overweight and obese patients with and without binge eating disorder in primary care
Ivezaj V, Kalebjian R, Grilo CM, Barnes RD. Comparing weight gain in the year prior to treatment for overweight and obese patients with and without binge eating disorder in primary care. Journal Of Psychosomatic Research 2014, 77: 151-154. PMID: 25077857, PMCID: PMC4118055, DOI: 10.1016/j.jpsychores.2014.05.006.Peer-Reviewed Original ResearchConceptsObese patientsBED patientsBinge-eating frequencyWeight gainPrimary careWeight changeCurrent weightGreater eating-disorder psychopathologyNBO patientsWeight change trajectoriesPrimary care physiciansWeight loss treatmentBeck Depression Inventory-IIFurther weight gainEating-disorder psychopathologyRapid weight gainEating Disorder ExaminationCare physiciansWeight historySelf-report questionnairesOverall groupDepression scoresIndependent significant contributionPatientsOverweightDevelopment and Validation of the Eating Loss of Control Scale
Blomquist KK, Roberto CA, Barnes RD, White MA, Masheb RM, Grilo CM. Development and Validation of the Eating Loss of Control Scale. Psychological Assessment 2014, 26: 77-89. PMID: 24219700, PMCID: PMC4021596, DOI: 10.1037/a0034729.Peer-Reviewed Original ResearchConceptsObjective bulimic episodesLoss of controlSelf-report questionnairesLOC episodesBulimic episodesControl ScaleBulimia nervosaEating Disorder Examination interviewGreater emotion dysregulationGreater eating pathologySelf-report measuresTreatment-seeking individualsSubjective bulimic episodesGood convergent validityGood internal reliabilityEmotion dysregulationEating PathologyNonclinical sampleExamination interviewValid self-report questionnaireConvergent validityLOC constructInternal reliabilityInitial validationLikert-type scale
2011
A Controlled Evaluation of the Distress Criterion for Binge Eating Disorder
Grilo CM, White MA. A Controlled Evaluation of the Distress Criterion for Binge Eating Disorder. Journal Of Consulting And Clinical Psychology 2011, 79: 509-514. PMID: 21707133, PMCID: PMC3264327, DOI: 10.1037/a0024259.Peer-Reviewed Original ResearchConceptsGreater eating-disorder psychopathologyEating-disorder psychopathologyBody mass indexBulimia nervosaBED groupDepressive levelsDistress criteriaDepression levelsComparison groupDiagnosis of BEDBinge Eating DisorderObese participantsMass indexStudy groupControlled EvaluationMarked distressMental disordersStatistical ManualBN groupResearch criteriaEating DisordersCommunity volunteersSelf-report instrumentDisordersCriterion CExamining the interpersonal model of binge eating and loss of control over eating in women
Ansell EB, Grilo CM, White MA. Examining the interpersonal model of binge eating and loss of control over eating in women. International Journal Of Eating Disorders 2011, 45: 43-50. PMID: 21321985, PMCID: PMC3582661, DOI: 10.1002/eat.20897.Peer-Reviewed Original ResearchDiagnostic Efficiency of DSM–IV Indicators for Binge Eating Episodes
White MA, Grilo CM. Diagnostic Efficiency of DSM–IV Indicators for Binge Eating Episodes. Journal Of Consulting And Clinical Psychology 2011, 79: 75-83. PMID: 21261436, PMCID: PMC3078698, DOI: 10.1037/a0022210.Peer-Reviewed Original Research
2010
Personality heterogeneity in female adolescent inpatients with features of eating disorders
Hopwood CJ, Ansell EB, Fehon DC, Grilo CM. Personality heterogeneity in female adolescent inpatients with features of eating disorders. Comprehensive Psychiatry 2010, 51: 585-591. PMID: 20965304, PMCID: PMC2962865, DOI: 10.1016/j.comppsych.2010.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAlcoholismAnorexia NervosaBody ImageBulimiaBulimia NervosaCluster AnalysisComorbidityDefense MechanismsFemaleHumansImpulsive BehaviorInternal-External ControlMood DisordersPatient AdmissionPersonality DisordersPersonality InventoryPsychometricsReproducibility of ResultsSelf ConceptSocial ConformitySubstance-Related DisordersConceptsImportant clinical implicationsDisorder featuresFemale adolescent inpatientsDisturbed eatingMood dysfunctionPersonality heterogeneityClinical implicationsAdult womenClinical useComorbid psychopathologyAdolescent inpatientsPersonality variabilitySubstance useDisorder symptomsAdolescent girlsFunctioning groupMood psychopathologyEatingHigh functioningDifferent personality modelsExternalizing groupWomenPrevious evidencePsychopathologySelf‐reported weight gain following smoking cessation: A function of binge eating behavior
White MA, Masheb RM, Grilo CM. Self‐reported weight gain following smoking cessation: A function of binge eating behavior. International Journal Of Eating Disorders 2010, 43: 572-575. PMID: 19718662, PMCID: PMC2895960, DOI: 10.1002/eat.20729.Peer-Reviewed Original Research
2007
Naltrexone and Cognitive Behavioral Coping Skills Therapy for the Treatment of Alcohol Drinking and Eating Disorder Features in Alcohol‐Dependent Women: A Randomized Controlled Trial
O'Malley SS, Sinha R, Grilo CM, Capone C, Farren CK, McKee SA, Rounsaville BJ, Wu R. Naltrexone and Cognitive Behavioral Coping Skills Therapy for the Treatment of Alcohol Drinking and Eating Disorder Features in Alcohol‐Dependent Women: A Randomized Controlled Trial. Alcohol Clinical And Experimental Research 2007, 31: 625-634. PMID: 17374042, DOI: 10.1111/j.1530-0277.2007.00347.x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAlcohol DrinkingAlcoholismAttitudeBody Mass IndexBulimiaCognitive Behavioral TherapyCombined Modality TherapyDepressionFeeding and Eating DisordersFemaleGamma-GlutamyltransferaseHumansNaltrexoneNarcotic AntagonistsPsychiatric Status Rating ScalesTreatment OutcomeConceptsCognitive Behavioral Coping Skills TherapyAlcohol-dependent womenEfficacy of naltrexoneCoping skills therapyAlcohol dependenceOutpatient research clinicSkills therapyCo-occurring psychiatric conditionsEating Disorder FeaturesDSM-IV criteriaPercentage of participantsPrimary outcomeControlled TrialsAlcohol drinkingMedication conditionResearch clinicNaltrexonePsychiatric conditionsSecondary analysisImportant gender differencesTotal abstinenceHeavy drinkingPathologyWomenDrinking outcomes
2006
The prognostic significance of regular binge eating in extremely obese gastric bypass patients: 12-month postoperative outcomes.
White MA, Masheb RM, Rothschild BS, Burke-Martindale CH, Grilo CM. The prognostic significance of regular binge eating in extremely obese gastric bypass patients: 12-month postoperative outcomes. The Journal Of Clinical Psychiatry 2006, 67: 1928-35. PMID: 17194271, DOI: 10.4088/jcp.v67n1213.Peer-Reviewed Original ResearchConceptsNon-binge eatersRegular bingeBinge eatersObese gastric bypass patientsAssessment of bingeBinge-eating groupBinge-eating statusObese bariatric surgery candidatesRobust improvementBariatric surgery candidatesBody dissatisfactionInfrequent bingePsychosocial functioningPreoperative bingePsychological problemsPsychosocial problemsBingeEatersMonths postsurgerySurgery candidatesEatingGastric bypass surgery patientsPostoperative outcomesPrognostic significanceSharp improvement
2005
Cognitive Behavioral Therapy Guided Self-Help and Orlistat for the Treatment of Binge Eating Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
Grilo CM, Masheb RM, Salant SL. Cognitive Behavioral Therapy Guided Self-Help and Orlistat for the Treatment of Binge Eating Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. Biological Psychiatry 2005, 57: 1193-1201. PMID: 15866560, DOI: 10.1016/j.biopsych.2005.03.001.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyWeight lossSelf-help cognitive behavioral therapyAddition of placeboFacilitate weight lossTreat remission ratesPercent of patientsDouble-blind fashionPlacebo-controlled studyAddition of orlistatGreater weight lossGuided Self-HelpObese BED patientsBinge Eating DisorderRemission rateTreatment discontinuationClinical improvementObesity medicationsBED patientsCBTgshOrlistatPlaceboBehavioral therapyDisorder psychopathologyComparable improvementEfficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: A randomized double-blind placebo-controlled comparison
Grilo CM, Masheb RM, Wilson GT. Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: A randomized double-blind placebo-controlled comparison. Biological Psychiatry 2005, 57: 301-309. PMID: 15691532, DOI: 10.1016/j.biopsych.2004.11.002.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBehavioral therapyEfficacy of CBTTreatment of bingeTreat remission ratesCBT conditionCognitive featuresPsychological featuresPsychological distressDimensional measuresBingeRemission rateDouble-blind placebo-controlled comparisonDouble-blind fashionPlacebo-controlled comparisonPlacebo-controlled studyConsistent findingCompletersIndividual treatmentCertain medicationsPharmacological therapyITT analysisFluoxetineDisordersPlacebo