1991
Amelioration of renal ischemic injury by phosphocreatine
Rodriguez R, Stepke M, Maitz S, Cuono C, Sumpio B. Amelioration of renal ischemic injury by phosphocreatine. Journal Of Surgical Research 1991, 51: 271-274. PMID: 1921364, DOI: 10.1016/0022-4804(91)90106-v.Peer-Reviewed Original ResearchConceptsRenal ischemic injuryInitial ischemic insultPerfusion of kidneysKrebs-bicarbonate solutionMin of normothermicMM phosphocreatineRenal functionIschemic injuryKidney functionIschemic insultRenal arteryVivo ischemiaWarm ischemiaKrebs solutionKidneyPhosphocreatineAddition of phosphocreatineIschemiaSignificant improvementRegeneration of ATPGFRArteryNormothermicUreterInjury
1989
The influence of perfusate viscosity, RBC deformability and drag on the function of an isolated perfused rat kidney
Sumpio B, Upchurch G, Johnson G. The influence of perfusate viscosity, RBC deformability and drag on the function of an isolated perfused rat kidney. Journal Of Surgical Research 1989, 46: 4-8. PMID: 2915534, DOI: 10.1016/0022-4804(89)90174-1.Peer-Reviewed Original ResearchConceptsRenal functionMean renal arterial pressureRat kidneyKrebs-HCO3 bufferRenal arterial pressureReabsorption of sodiumArterial pressureUrine flowOrgan functionClinical interestHCO3- bufferPerfusate solutionHematocritBlood rheologyFunctional parametersPerfusate viscosityRBC deformabilityKidneyPerfusateDegrees CRBCsDrag-reducing agentsGFRCreatinineAgents
1985
Renal handling of proteins in normal and disease states.
Sumpio B, Hayslett J. Renal handling of proteins in normal and disease states. QJM 1985, 57: 611-35. PMID: 4080952.Peer-Reviewed Original Research
1984
Renal hydrolysis of absorbed protein: influence of load and lysosomal pH
Camargo MJ, Sumpio BE, Maack T. Renal hydrolysis of absorbed protein: influence of load and lysosomal pH. American Journal Of Physiology 1984, 247: f656-f664. PMID: 6093557, DOI: 10.1152/ajprenal.1984.247.4.f656.Peer-Reviewed Original ResearchConceptsNormal filtered loadEfflux of radioactivityRenal tubular cellsEffect of alkalinizationProtein absorption dropletsRenal catabolismNormal lysosomal functionLysosomotropic weak basesFiltered loadTubular cellsKidney 1Abnormal depositionRat kidneyKidneyAbsorption dropletsSaturable processIntracellular hydrolysisSaturable functionLysosomal functionPerfusateLysosomal pHLow uptake rateSephadex chromatographyReversible mannerHalf timesKinetics of Renal Catabolism of Absorbed Proteins: Influence of Lysosomal pH
Camargo M, Sumpio B, Maack T. Kinetics of Renal Catabolism of Absorbed Proteins: Influence of Lysosomal pH. Contributions To Nephrology 1984, 42: 19-29. PMID: 6099789, DOI: 10.1159/000409957.Peer-Reviewed Original Research