2008
The Effect of Different Frequencies of Stretch on Human Dermal Keratinocyte Proliferation and Survival
Nishimura K, Blume P, Ohgi S, Sumpio BE. The Effect of Different Frequencies of Stretch on Human Dermal Keratinocyte Proliferation and Survival. Journal Of Surgical Research 2008, 155: 125-131. PMID: 19059608, DOI: 10.1016/j.jss.2008.07.029.Peer-Reviewed Original ResearchConceptsERK 1/2P38 MAPKProtein kinaseKeratinocyte proliferation rateCell deathAkt inhibitorCyclic stretchDNA synthesisAktTransferase-mediated dUTP nick-end labeling stainingRepetitive stretchApoptosisMAPKDUTP nick end labeling stainingProliferation rateHuman dermalCell numberNick end labeling stainingTUNEL-positive cellsDermal keratinocytesStretchTerminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) stainingBrdU stainingKeratinocyte proliferationProliferation
2005
Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis
Poussier B, Cordova AC, Becquemin JP, Sumpio BE. Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis. Journal Of Vascular Surgery 2005, 42: 1190-1190.e14. PMID: 16376213, DOI: 10.1016/j.jvs.2005.08.014.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsAnimals, NewbornAntioxidantsAorta, ThoracicApoptosisBlotting, WesternCattleCell ProliferationCells, CulturedDNADose-Response Relationship, DrugFlow CytometryIn Situ Nick-End LabelingIn Vitro TechniquesMuscle, Smooth, VascularProliferating Cell Nuclear AntigenResveratrolStilbenesConceptsSmooth muscle cell proliferationMuscle cell proliferationVascular smooth muscle cell proliferationDose-dependent mannerSMC proliferationCell proliferationG1-S phaseBeneficial effectsFrench paradoxDose-dependent apoptotic effectTerminal deoxynucleotidyl transferase-mediated dUTP-biotin nickTransferase-mediated dUTP-biotin nickCardiovascular death ratesRed wine intakeRed wine consumptionEffects of resveratrolAortic SMC proliferationEnd labeling stainingVascular SMC proliferationDUTP-biotin nickMajor polyphenol componentHealthy life styleCell cycle analysisCardiovascular mortalityFlow-activated cell sorting
2002
Transcription Factor Sp1 Phosphorylation Induced by Shear Stress Inhibits Membrane Type 1-Matrix Metalloproteinase Expression in Endothelium*
Yun S, Dardik A, Haga M, Yamashita A, Yamaguchi S, Koh Y, Madri JA, Sumpio BE. Transcription Factor Sp1 Phosphorylation Induced by Shear Stress Inhibits Membrane Type 1-Matrix Metalloproteinase Expression in Endothelium*. Journal Of Biological Chemistry 2002, 277: 34808-34814. PMID: 12093818, DOI: 10.1074/jbc.m205417200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCells, CulturedDNADNA-Binding ProteinsEarly Growth Response Protein 1Electrophoretic Mobility Shift AssayEndothelium, VascularImmediate-Early ProteinsMatrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesNogalamycinPhosphorylationPromoter Regions, GeneticRatsRats, Sprague-DawleyRNA, MessengerSp1 Transcription FactorStress, PhysiologicalTranscription FactorsConceptsMT1-MMP expressionEgr-1MRNA transcriptionMT1-MMP promoterPost-translational modificationsCalf intestinal phosphataseDistinct environmental stimuliTranscription factor expressionSp1 phosphorylationEgr-1 expressionSp1 DNAEndothelial cell migrationSerine phosphorylationPromoter sitesSp1Cell migrationEnvironmental stimuliMatrix remodelingIntestinal phosphataseProtein levelsTranscriptionTime-dependent fashionPhosphorylationMechanical forcesExpression
1998
Understanding molecular biology.
Gahtan V, Peyman JA, Sumpio BE. Understanding molecular biology. Seminars In Vascular Surgery 1998, 11: 125-33. PMID: 9763112.Peer-Reviewed Original ResearchAmbient Pulsatile Pressure Modulates Endothelial Cell Proliferation
Vouyouka A, Powell R, Ricotta J, Chen H, Dudrick D, Sawmiller C, Dudrick S, Sumpio B. Ambient Pulsatile Pressure Modulates Endothelial Cell Proliferation. Journal Of Molecular And Cellular Cardiology 1998, 30: 609-615. PMID: 9515036, DOI: 10.1006/jmcc.1997.0625.Peer-Reviewed Original Research
1997
Effect of strain on human keratinocytes in vitro
Takei T, Rivas‐Gotz C, Delling C, Koo J, Mills I, McCarthy T, Centrella M, Sumpio B. Effect of strain on human keratinocytes in vitro. Journal Of Cellular Physiology 1997, 173: 64-72. PMID: 9326450, DOI: 10.1002/(sici)1097-4652(199710)173:1<64::aid-jcp8>3.0.co;2-h.Peer-Reviewed Original Research
1994
Inhibition of smooth muscle cell proliferation by visible light-activated psoralen.
Sumpio BE, Li G, Deckelbaum LI, Gasparro FP. Inhibition of smooth muscle cell proliferation by visible light-activated psoralen. Circulation Research 1994, 75: 208-213. PMID: 8033334, DOI: 10.1161/01.res.75.2.208.Peer-Reviewed Original Research
1993
Control of smooth muscle cell proliferation by psoralen photochemotherapy
Sumpio B, Phan S, Gasparro F, Deckelbaum L. Control of smooth muscle cell proliferation by psoralen photochemotherapy. Journal Of Vascular Surgery 1993, 17: 1010-1018. DOI: 10.1016/0741-5214(93)90671-8.Peer-Reviewed Original ResearchConceptsSmooth muscle cell proliferationMuscle cell proliferationSMC proliferationPsoralen photochemotherapyPeripheral vascular diseaseLong-term therapyCell proliferationInhibits SMC proliferationTrypan blue exclusionBypass graftDistal anastomosisBalloon angioplastyUVA photochemotherapyVascular diseaseIntimal hyperplasiaGrowth of SMCsBlue exclusionPhotochemotherapySMC viabilityTime courseProliferationUVADNA synthesisDaysAngioplastyControl of smooth muscle cell proliferation by psoralen photochemotherapy.
Sumpio B, Phan S, Gasparro F, Deckelbaum L. Control of smooth muscle cell proliferation by psoralen photochemotherapy. Journal Of Vascular Surgery 1993, 17: 1010-6; discussion 1016-8. PMID: 8505779, DOI: 10.1067/mva.1993.45747.Peer-Reviewed Original ResearchConceptsSmooth muscle cell proliferationMuscle cell proliferationSMC proliferationPsoralen photochemotherapyPeripheral vascular diseaseLong-term therapyCell proliferationInhibits SMC proliferationTrypan blue exclusionBypass graftDistal anastomosisBalloon angioplastyUVA photochemotherapyVascular diseaseIntimal hyperplasiaGrowth of SMCsBlue exclusionPhotochemotherapySMC viabilityTime courseProliferationUVADNA synthesisDaysAngioplastyTHE EXCITATION OF 8‐METHOXYPSORALEN WITH VISIBLE LIGHT: REVERSED PHASE HPLC QUANTITATION OF MONOADDUCTS and CROSS‐LINKS
Gasparro F, Gattolin P, Olack G, Deckelbaum L, Sumpio B. THE EXCITATION OF 8‐METHOXYPSORALEN WITH VISIBLE LIGHT: REVERSED PHASE HPLC QUANTITATION OF MONOADDUCTS and CROSS‐LINKS. Photochemistry And Photobiology 1993, 57: 1007-1009. PMID: 8367529, DOI: 10.1111/j.1751-1097.1993.tb02963.x.Peer-Reviewed Original Research
1988
Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension in vitro.
Buckley MJ, Banes AJ, Levin LG, Sumpio BE, Sato M, Jordan R, Gilbert J, Link GW, Tran Son Tay R. Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension in vitro. Bone And Mineral 1988, 4: 225-36. PMID: 2847838.Peer-Reviewed Original ResearchResponse of porcine aortic smooth muscle cells to cyclic tensional deformation in culture
Sumpio B, Banes A. Response of porcine aortic smooth muscle cells to cyclic tensional deformation in culture. Journal Of Surgical Research 1988, 44: 696-701. PMID: 3379947, DOI: 10.1016/0022-4804(88)90103-5.Peer-Reviewed Original Research
1987
Mechanical stress stimulates aortic endothelial cells to proliferate
Sumpio B, Banes A, Levin L, Johnson G. Mechanical stress stimulates aortic endothelial cells to proliferate. Journal Of Vascular Surgery 1987, 6: 252-256. PMID: 3625881, DOI: 10.1016/0741-5214(87)90037-1.Peer-Reviewed Original Research