2002
SPHINGOSINE-1-PHOSPHATE STIMULATES HUMAN CACO-2 INTESTINAL EPITHELIAL PROLIFERATION VIA p38 ACTIVATION AND ACTIVATES ERK BY AN INDEPENDENT MECHANISM
THAMILSELVAN V, LI W, SUMPIO BE, BASSON MD. SPHINGOSINE-1-PHOSPHATE STIMULATES HUMAN CACO-2 INTESTINAL EPITHELIAL PROLIFERATION VIA p38 ACTIVATION AND ACTIVATES ERK BY AN INDEPENDENT MECHANISM. In Vitro Cellular & Developmental Biology - Animal 2002, 38: 246-253. PMID: 12197778, DOI: 10.1290/1071-2690(2002)038<0246:spshci>2.0.co;2.Peer-Reviewed Original ResearchConceptsExtracellular signal-regulated kinases 1Mitogen-activated protein kinaseMAP kinase kinaseCaco-2 proliferationMAPK activationHuman intestinal epithelial proliferationP38 activationCell typesSignal-regulated kinases 1Role of ERKMitogenic effectCaco-2 intestinal epithelial cellsIntracellular second messengerMEK inhibitionP38 MAPK activationCancer cell invasionKinase kinaseHuman Caco-2 intestinal epithelial cellsProtein kinaseStimulation of proliferationCell motilityIntestinal epithelial cell proliferationInhibitor PD98059ERK2ERK activation
2000
Effects of increased ambient pressure on colon cancer cell adhesion
Basson M, Yu C, Herden‐Kirchoff O, Ellermeier M, Sanders M, Merrell R, Sumpio B. Effects of increased ambient pressure on colon cancer cell adhesion. Journal Of Cellular Biochemistry 2000, 78: 47-61. PMID: 10797565, DOI: 10.1002/(sici)1097-4644(20000701)78:1<47::aid-jcb5>3.0.co;2-m.Peer-Reviewed Original ResearchConceptsColon cancer cell adhesionCancer cell adhesionTyrosine phosphorylationCell adhesionPressure-stimulated adhesionFocal adhesion kinaseHuman colon cancer cellsIntestinal epithelial biologyColon cancer cellsColon cancer cell linesHuman colon cancer cell linesBeta1 integrin subunitsHuman colon cancerAdhesion kinaseBovine aortic smooth muscle cellsAortic smooth muscle cellsIntracellular proteinsEpithelial biologyMatrix proteinsAbsence of serumIntegrin subunitsCancer cell linesPrimary cellsSmooth muscle cellsKinase inhibition
1986
Perforated appendicitis and obstructing colonic carcinoma in the elderly
Sumpio B, Ballantyne G, Zdon M, Modlin I. Perforated appendicitis and obstructing colonic carcinoma in the elderly. Diseases Of The Colon & Rectum 1986, 29: 668-670. PMID: 3757711, DOI: 10.1007/bf02560335.Peer-Reviewed Original ResearchConceptsPerforated appendicitisColonic carcinomaPercent of patientsMajority of patientsYears of ageAppendiceal lumenElderly patientsFaecal fistulaLymphoid hyperplasiaOccult bloodCarcinoid tumorsSecond patientBarium enemaFirst patientColonic cancerDiagnostic colonoscopySigmoid carcinomaColonic neoplasmsCommon causeAppendicitisSuch lesionsPatientsCarcinomaAppendectomyMen