2001
The Integrin-Mediated Cyclic Strain-Induced Signaling Pathway in Vascular Endothelial Cells
Frangos S, Knox R, Yano Y, Chen E, Di Luozzo G, Chen A, Sumpio B. The Integrin-Mediated Cyclic Strain-Induced Signaling Pathway in Vascular Endothelial Cells. Endothelium 2001, 8: 1-10. PMID: 11409847, DOI: 10.3109/10623320109063153.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinase (MAPK) familyCytoplasmic protein kinaseProtein kinase familySignal transduction pathwaysFocal adhesion kinaseExtracellular matrix receptorsProcess of phosphorylationEndothelial cellsKinase familySignal transductionTranscription factorsAdhesion kinaseProtein kinaseTransduction pathwaysMatrix receptorsGene expressionTyrosine residuesSignaling pathwaysCyclic circumferential strainVascular endothelial cellsPathwayKinaseIntegrinsHemodynamic forcesVasculature results
1998
Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals
Han O, Di Li G, Sumpio B, Basson M. Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals. American Journal Of Physiology 1998, 275: g534-g541. PMID: 9724266, DOI: 10.1152/ajpgi.1998.275.3.g534.Peer-Reviewed Original Research
1997
Cyclic strain stimulates isoform‐specific PKC activation and translocation in cultured human keratinocytes
Takei T, Han O, Ikeda M, Male P, Mills I, Sumpio B. Cyclic strain stimulates isoform‐specific PKC activation and translocation in cultured human keratinocytes. Journal Of Cellular Biochemistry 1997, 67: 327-337. PMID: 9361188, DOI: 10.1002/(sici)1097-4644(19971201)67:3<327::aid-jcb5>3.0.co;2-y.Peer-Reviewed Original Research
1992
Immunocytochemical expression and localization of protein kinase C in bovine aortic endothelial cells
Rosales O, Isales C, Nathanson M, Sumpio B. Immunocytochemical expression and localization of protein kinase C in bovine aortic endothelial cells. Biochemical And Biophysical Research Communications 1992, 189: 40-46. PMID: 1449492, DOI: 10.1016/0006-291x(92)91522-r.Peer-Reviewed Original ResearchConceptsSerum-deprived mediumPKC activityPhorbol ester-induced increaseAortic endothelial cellsBovine aortic endothelial cellsBeta stainingSDM groupTotal PKC activityImmunocytochemical expressionBeta PKC isoformsEndothelial cellsParticulate fractionFBS groupProtein kinase CCalphostin CPKC inhibitorPhorbol esterConfocal microscopyDiffuse cytoplasmic localizationCytosolic fractionGamma-PKCKinase CPKC isoformsCytoplasmic localizationCells
1990
Mechanosensitive adenylate cyclase activity in coronary vascular smooth muscle cells
Mills I, Letsou G, Rabban J, Sumpio B, Gewirtz H. Mechanosensitive adenylate cyclase activity in coronary vascular smooth muscle cells. Biochemical And Biophysical Research Communications 1990, 171: 143-147. PMID: 2393388, DOI: 10.1016/0006-291x(90)91368-3.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsCoronary vascular smooth muscle cellsMuscle cellsCyclase activityPorcine coronary artery smooth muscle cellsCultured vascular smooth muscle cellsArtery smooth muscle cellsCoronary artery smooth muscle cellsVascular smooth muscleMagnitude of stretchStretch-induced reductionAdenylate cyclase activityPotential biochemical mechanismsPerfusion pressureCoronary circulationCycles/minMyogenic responseSmooth muscleMechanical stretchAdenylate cyclasePotential mechanismsEntire time courseUnstretched cellsTime course