2005
Shear stress-stimulated endothelial cells induce smooth muscle cell chemotaxis via platelet-derived growth factor-BB and interleukin-1α
Dardik A, Yamashita A, Aziz F, Asada H, Sumpio BE. Shear stress-stimulated endothelial cells induce smooth muscle cell chemotaxis via platelet-derived growth factor-BB and interleukin-1α. Journal Of Vascular Surgery 2005, 41: 321-331. PMID: 15768016, DOI: 10.1016/j.jvs.2004.11.016.Peer-Reviewed Original ResearchConceptsSignal transduction pathwaysPlatelet-derived growth factorSMC chemotaxisCell signal transduction pathwaysMitogen-activated protein kinase pathwaySmooth muscle cell chemotaxisERK1/2 phosphorylationPDGF-BBExtracellular signal-regulated protein kinase 1/2Pathway inhibitor PD98059Protein kinase pathwayEndothelial cellsERK1/2 signal transduction pathwayProtein kinase 1/2Vascular smooth muscle cell migrationBovine aortic endothelial cellsKinase pathwayInhibitor PD98059Smooth muscle cell migrationHemodynamic forcesKinase 1/2Platelet-derived growthMuscle cell migrationWestern blot analysisTarget pathways
1998
Regulation of PDGF-B in Endothelial Cells Exposed to Cyclic Strain
Sumpio B, Du W, Galagher G, Wang X, Khachigian L, Collins T, Gimbrone M, Resnick N. Regulation of PDGF-B in Endothelial Cells Exposed to Cyclic Strain. Arteriosclerosis Thrombosis And Vascular Biology 1998, 18: 349-355. PMID: 9514402, DOI: 10.1161/01.atv.18.3.349.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCells, CulturedEndothelium, VascularHumansNuclear ProteinsPlatelet-Derived Growth FactorProto-Oncogene ProteinsProto-Oncogene Proteins c-sisStress, MechanicalTranscription, GeneticConceptsShear stress response element