2006
p38 Mitogen-Activated Protein Kinase Activation in Endothelial Cell Is Implicated in Cell Alignment and Elongation Induced by Fluid Shear Stress
Kadohama T, Akasaka N, Nishimura K, Hoshino Y, Sasajima T, Sumpio BE. p38 Mitogen-Activated Protein Kinase Activation in Endothelial Cell Is Implicated in Cell Alignment and Elongation Induced by Fluid Shear Stress. Endothelium 2006, 13: 43-50. PMID: 16885066, DOI: 10.1080/10623320600660219.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesAtherosclerosisBlood PressureBlood VesselsCattleCell PolarityCell ShapeCells, CulturedDose-Response Relationship, DrugEndothelial CellsEnzyme ActivationEnzyme InhibitorsHemodynamicsMAP Kinase Signaling SystemP38 Mitogen-Activated Protein KinasesPhosphorylationRegional Blood FlowStress, MechanicalTime FactorsConceptsStatic endothelial cellsFluid shear stressP38 MAPKP38 Mitogen-Activated Protein Kinase ActivationMitogen-Activated Protein Kinase ActivationEndothelial cellsProtein kinase activationP38 MAPK inhibitor SB-203580Inhibitor SB 203580Cell alignmentProtein kinaseBovine aortic endothelial cellsLaminar shear stressKinase activationSB 203580P38 mitogenCultured bovine aortic endothelial cellsEC elongationAortic endothelial cellsMAPKCellsElongationActivationMorphometric analysisKinase
2001
Intermittent Pneumatic Compression Devices – Physiological Mechanisms of Action
Chen AH, Frangos SG, Kilaru S, Sumpio BE. Intermittent Pneumatic Compression Devices – Physiological Mechanisms of Action. European Journal Of Vascular And Endovascular Surgery 2001, 21: 383-392. PMID: 11352511, DOI: 10.1053/ejvs.2001.1348.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomechanical PhenomenaBlood CirculationBlood VesselsGravity SuitsHumansVenous ThrombosisConceptsLower extremity arterial diseaseDeep venous thrombosisExtremity arterial diseaseImprovement of circulationUse of IPCExact physiological mechanismsCultured endothelial cellsVenous thrombosisVenous ulcersArterial diseaseLower extremitiesTherapeutic effectClinical utilityClinical relevanceClinical settingBeneficial effectsEndothelial cellsSubsequent biochemical changesPutative mechanismsBiochemical changesPhysiological mechanismsThrombosisUlcersPatientsLymphoedema