1997
Gene Regulation by Mechanical Forces
Oluwole BO, Du W, Mills I, Sumpio BE. Gene Regulation by Mechanical Forces. Endothelium 1997, 5: 85-93. PMID: 9237042, DOI: 10.3109/10623329709079866.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell Adhesion MoleculesCell Culture TechniquesCells, CulturedEndothelinsEndothelium, VascularEpoprostenolFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGene Expression RegulationHemorheologyHumansMechanoreceptorsMembranes, ArtificialNitric OxideProtein-Tyrosine KinasesSignal TransductionStress, MechanicalTissue Plasminogen ActivatorTranscription FactorsTranscription, GeneticVacuumConceptsEndothelial cellsEndothelial cell functionCyclic strainVasoactive mediatorsSecond messenger cascadesNitric oxideBlood vesselsMechanical forcesCell functionMechanical deformationFlow of bloodMessenger cascadesLuminal surfaceSpecific response elementsPromoter geneResponse elementExternal forcesMediatorsCytoskeletal changesCellsForceProstacyclinExpressionTranscription levels
1995
Endothelial Cell Control of Vasomotor Tone
Oluwole B, McMillen M, Sumpio B. Endothelial Cell Control of Vasomotor Tone. Annals Of Vascular Surgery 1995, 9: 293-301. PMID: 7543275, DOI: 10.1007/bf02135291.Peer-Reviewed Original ResearchEndothelins: polyfunctional cytokines.
McMillen MA, Sumpio BE. Endothelins: polyfunctional cytokines. Journal Of The American College Of Surgeons 1995, 180: 621-37. PMID: 7749544.Peer-Reviewed Original ResearchAdrenal GlandsAmino Acid SequenceCell Transformation, NeoplasticCytokinesDigestive SystemEndothelinsEndothelium, VascularHumansInsulinKidneyLiverLungMacrophagesMolecular Sequence DataMonocytesMuscle, Smooth, VascularMyocardiumNeutrophilsParathyroid GlandsPeripheral Vascular DiseasesPituitary Gland, AnteriorProtein BindingReceptors, EndothelinThyroid GlandEndothelial-leukocyte interactions in the neutrophil cascade
McMillen M, Sumpio B. Endothelial-leukocyte interactions in the neutrophil cascade. The American Journal Of Surgery 1995, 169: 186-187. PMID: 7817990, DOI: 10.1016/s0002-9610(99)80130-5.Peer-Reviewed Original ResearchEndothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6
McMillen M, Huribal M, Cunningham M, Kumar R, Sumpio B. Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6. Critical Care Medicine 1995, 23: 34-40.. PMID: 8001384, DOI: 10.1097/00003246-199501000-00009.Peer-Reviewed Original ResearchConceptsEndothelin-1Intracellular calciumHuman monocytesIL-6Production of interleukinIL-6 productionIL-1 productionIntracellular calcium concentrationBasic science laboratoryM endothelinInterleukin-6Healthy donorsFura-2Control monocytesIschemic endotheliumMonocytesEndothelinCalcium concentrationMean valueCalciumTissue cultureInterleukinPhytohemagglutininEndotheliumEndotoxin
1994
ENDOTHELIN-STIMULATED MONOCYTE SUPERNATANTS ENHANCE NEUTROPHIL SUPEROXIDE PRODUCTION
Huribal M, Kumar R, Cunningham M, Sumpio B, McMillen M. ENDOTHELIN-STIMULATED MONOCYTE SUPERNATANTS ENHANCE NEUTROPHIL SUPEROXIDE PRODUCTION. Shock 1994, 1: 184-187. PMID: 7735949, DOI: 10.1097/00024382-199403000-00005.Peer-Reviewed Original ResearchConceptsEndothelin-1Neutrophil superoxide productionIL-8Monocyte supernatantsSuperoxide productionInterleukin-8 contentHuman peripheral blood monocytesPotent neutrophil activatorVascular smooth musclePeripheral blood monocytesIncubation of neutrophilsInterleukin-6M ETNeutrophil activatorProstaglandin E2Smooth muscleVasoconstrictive peptideBlood monocytesMonocytesBasal levelsNeutrophilsSupernatantH incubationDirect effectEndothelin
1993
Endothelin-Stimulated Human Monocytes Produce Prostaglandin E2 but Not Leukotriene B4
McMillen M, Huribal M, Kumar R, Sumpio B. Endothelin-Stimulated Human Monocytes Produce Prostaglandin E2 but Not Leukotriene B4. Journal Of Surgical Research 1993, 54: 331-335. PMID: 8392650, DOI: 10.1006/jsre.1993.1053.Peer-Reviewed Original ResearchConceptsProstaglandin E2Pg/Human monocytesPost-traumatic immunosuppressionMonocytes/macrophagesBacterial lipopolysaccharide (LPS) stimulationEndothelin increaseM endothelinInterleukin-6Immune functionLeukotriene B4PGE2 productionVascular endotheliumEndothelinLipopolysaccharide (LPS) stimulationInjuryMonocytesAcid peptideE2B4HrActivationImmunosuppressionIschemiaMajor role
1990
Enhanced production of endothelium-derived contracting factor by endothelial cells subjected to pulsatile stretch.
Sumpio BE, Widmann MD. Enhanced production of endothelium-derived contracting factor by endothelial cells subjected to pulsatile stretch. Surgery 1990, 108: 277-81; discussion 281-2. PMID: 2200155.Peer-Reviewed Original Research