1997
Gene Regulation by Mechanical Forces
Oluwole BO, Du W, Mills I, Sumpio BE. Gene Regulation by Mechanical Forces. Endothelium 1997, 5: 85-93. PMID: 9237042, DOI: 10.3109/10623329709079866.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell Adhesion MoleculesCell Culture TechniquesCells, CulturedEndothelinsEndothelium, VascularEpoprostenolFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGene Expression RegulationHemorheologyHumansMechanoreceptorsMembranes, ArtificialNitric OxideProtein-Tyrosine KinasesSignal TransductionStress, MechanicalTissue Plasminogen ActivatorTranscription FactorsTranscription, GeneticVacuumConceptsEndothelial cellsEndothelial cell functionCyclic strainVasoactive mediatorsSecond messenger cascadesNitric oxideBlood vesselsMechanical forcesCell functionMechanical deformationFlow of bloodMessenger cascadesLuminal surfaceSpecific response elementsPromoter geneResponse elementExternal forcesMediatorsCytoskeletal changesCellsForceProstacyclinExpressionTranscription levels
1995
Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: Species and vascular bed diversity
Du W, Mills I, Sumpio B. Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: Species and vascular bed diversity. Journal Of Biomechanics 1995, 28: 1485-1491. PMID: 8666588, DOI: 10.1016/0021-9290(95)00096-8.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 2AnimalsAortaCattleCell DivisionCyclic AMP Response Element-Binding ProteinEndothelium, VascularEpoprostenolGene Expression RegulationGenes, Immediate-EarlyHumansNF-kappa BNuclear ProteinsPhenotypeProtein Kinase CSpecies SpecificityStress, MechanicalTime FactorsTranscription Factor AP-1Transcription FactorsUmbilical VeinsConceptsHuman umbilical vein endothelial cellsBovine aortic endothelial cellsActivator protein-1NF-kBEndothelial cellsVascular bedDifferent vascular bedsUmbilical vein endothelial cellsAortic endothelial cellsCultured endothelial cellsTranscription factor activator protein-1Vein endothelial cellsProstacyclin secretionStretch-induced activationImmediate early genesEC exposureNuclear factorTime pointsHeterogeneous inductionCAMP response elementProtein 1Biphasic mannerSignificant inductionDivergent effectsHuman aortaEndothelial Cell Control of Vasomotor Tone
Oluwole B, McMillen M, Sumpio B. Endothelial Cell Control of Vasomotor Tone. Annals Of Vascular Surgery 1995, 9: 293-301. PMID: 7543275, DOI: 10.1007/bf02135291.Peer-Reviewed Original Research
1993
Enhanced Patency of Venous Dacron Grafts by Endothelial Cell Sodding
Wang Z, Li G, Wu J, Du W, Pu L, Zhang H, Wang D, Sumpio B. Enhanced Patency of Venous Dacron Grafts by Endothelial Cell Sodding. Annals Of Vascular Surgery 1993, 7: 429-436. PMID: 8268088, DOI: 10.1007/bf02002126.Peer-Reviewed Original ResearchConceptsInferior vena cavaDacron graftEndothelial cell soddingVena cavaLess thromboxane A2Production of prostacyclinCanine inferior vena cavaPatency ratesThromboxane A2Neointimal thickeningControl graftsGraftPatencyGraft surfaceCavaProstacyclinDensity gradient centrifugationCanine omentumSignificant improvementConfluent layerGradient centrifugationOmentumA2Rapid endothelializationNeointima
1991
Effect of cyclic stretch on endothelial cells from different vascular beds.
Iba T, Maitz S, Furbert T, Rosales O, Widmann MD, Spillane B, Shin T, Sonoda T, Sumpio BE. Effect of cyclic stretch on endothelial cells from different vascular beds. Journal Of Inflammation 1991, 35: 193-8. PMID: 1777956.Peer-Reviewed Original Research
1988
Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation.
Sumpio BE, Banes AJ. Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation. Surgery 1988, 104: 383-9. PMID: 3135629.Peer-Reviewed Original Research