2018
Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds
Alvelo JL, Papademetris X, Mena-Hurtado C, Jeon S, Sumpio BE, Sinusas AJ, Stacy MR. Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds. Circulation Cardiovascular Imaging 2018, 11: e006932. PMID: 29748311, PMCID: PMC5951395, DOI: 10.1161/circimaging.117.006932.Peer-Reviewed Original ResearchMeSH KeywordsAnkle Brachial IndexCase-Control StudiesCritical IllnessDiabetic FootHumansIschemiaMicrocirculationOrganophosphorus CompoundsOrganotechnetium CompoundsPerfusion ImagingPredictive Value of TestsRadiopharmaceuticalsRegional Blood FlowSingle Photon Emission Computed Tomography Computed TomographyWound HealingConceptsCritical limb ischemiaAnkle-brachial indexStandardized uptake valueSPECT/CT imagingDiabetic patientsHealthy subjectsSPECT/CTFoot perfusionUptake valueLimb ischemiaMicrovascular perfusionSkeletal muscle microvascular perfusionCT imagingDiabetic CLI patientsMuscle microvascular perfusionPeripheral artery diseaseSingle photon emissionIntraclass correlation coefficientAngiosome perfusionCLI subjectsCLI patientsArtery diseaseDiabetes mellitusCT perfusionVascular territories
2016
Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease
Sumpio BJ, Citoni G, Chin JA, Sumpio BE. Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease. Journal Of Vascular Surgery 2016, 64: 1066-1073. PMID: 27266597, DOI: 10.1016/j.jvs.2016.03.463.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersBrachial ArteryCase-Control StudiesCoronary Artery DiseaseCross-Sectional StudiesEndothelium, VascularFemaleHemoglobinsHumansHyperemiaMaleMicrocirculationMiddle AgedMolecular ImagingOxyhemoglobinsPeripheral Arterial DiseasePilot ProjectsPredictive Value of TestsProspective StudiesReproducibility of ResultsSeverity of Illness IndexSkinSpectrum AnalysisUpper ExtremityVasodilationConceptsPeripheral artery diseaseCoronary artery diseaseCuff occlusionUpper armArtery diseaseVascular dysfunctionArterial diseasePresence of PADArterial disease patientsPeripheral arterial diseaseSystemic vascular dysfunctionAdvanced diseaseEndothelial dysfunctionVascular clinicProspective studySurgical historyControl cohortDisease patientsMedical recordsUpper extremityVascular bedHealthy volunteersPatientsHemoglobin concentrationDemographic data
2014
A comparison of open and endovascular revascularization for chronic mesenteric ischemia in a clinical decision model
Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Muhs BE, Sumpio BE. A comparison of open and endovascular revascularization for chronic mesenteric ischemia in a clinical decision model. Journal Of Vascular Surgery 2014, 60: 715-725.e2. PMID: 24721175, DOI: 10.1016/j.jvs.2014.03.009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComparative Effectiveness ResearchComputer SimulationCost-Benefit AnalysisDecision Support TechniquesEndovascular ProceduresFemaleHealth Care CostsHumansIschemiaMaleMarkov ChainsMesenteric IschemiaMiddle AgedPatient SelectionPredictive Value of TestsQuality of LifeQuality-Adjusted Life YearsReoperationRisk AssessmentRisk FactorsSex FactorsTime FactorsTreatment OutcomeVascular DiseasesVascular PatencyVascular Surgical ProceduresConceptsChronic mesenteric ischemiaIncremental cost-effectiveness ratioEndovascular revascularizationCost-effectiveness ratioMesenteric ischemiaFemale patientsMortality riskAge groupsGood short-term resultsDisease-specific mortality riskPatients 60 yearsOverall mortality riskMarkov state transition modelTreatment of choiceExpensive treatment strategiesShort-term resultsHealth care perspectiveHealth care costsDifferent clinical scenariosProbabilistic sensitivity analysesClinical decision modelDecision analysis modelOlder patientsConservative managementYounger patientsContemporary assessment of foot perfusion in patients with critical limb ischemia
Benitez E, Sumpio BJ, Chin J, Sumpio BE. Contemporary assessment of foot perfusion in patients with critical limb ischemia. Seminars In Vascular Surgery 2014, 27: 3-15. PMID: 25812754, DOI: 10.1053/j.semvascsurg.2014.12.001.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaLimb ischemiaFoot perfusionLower extremity perfusionPeripheral arterial diseaseTranscutaneous oxygen monitoringRevascularization techniquesArterial diseaseFoot ulcerationLimb salvageRevascularization therapyFluorescent angiographyPatient outcomesEndovascular proceduresDisease processPatient careIschemiaDiagnostic imagingPatientsPerfusionImaging modalitiesLaser DopplerOxygen monitoringPlanning interventionsModalities
2013
Clinical implications of the angiosome model in peripheral vascular disease
Sumpio BE, Forsythe RO, Ziegler KR, van Baal JG, Lepantalo MJ, Hinchliffe RJ. Clinical implications of the angiosome model in peripheral vascular disease. Journal Of Vascular Surgery 2013, 58: 814-826. PMID: 23972249, DOI: 10.1016/j.jvs.2013.06.056.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseVascular diseaseAngiosome modelVascular surgeryCritical limb ischemiaLarger patient populationReperfusion strategyProspective trialRevascularization attemptsSuccessful revascularizationLimb ischemiaSecondary amputationProspective studyFluorescent angiographyPatient populationVascular operationsAngiosome conceptEndovascular proceduresUnhealed woundsSystematic reviewClinical implicationsDiseaseSurgeryCurrent literatureSignificant rate
2009
The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy
Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy. Journal Of Vascular Surgery 2009, 50: 675-682.e1. PMID: 19595541, DOI: 10.1016/j.jvs.2009.05.017.Peer-Reviewed Original ResearchConceptsSemmes-Weinstein monofilament examinationDiabetic peripheral neuropathyNerve conduction studiesNegative predictive valuePositive predictive valueDiagnostic valueMonofilament examinationPeripheral neuropathyDiabetes mellitusPredictive valueLower extremity amputationRisk of ulcerationPublication date restrictionsCurrent literatureReference testConduction studiesExtremity amputationPlantar aspectDate restrictionsCurrent evidenceFifth metatarsalGreat toePubMed databaseEarly interventionIndependent investigators
1997
Effect of renal insufficiency on outcome following infrarenal aortic surgery
Powell R, Roddy S, Meier G, Gusberg R, Conte M, Sumpio B. Effect of renal insufficiency on outcome following infrarenal aortic surgery. The American Journal Of Surgery 1997, 174: 126-130. PMID: 9293827, DOI: 10.1016/s0002-9610(97)00069-x.Peer-Reviewed Original ResearchConceptsInfrarenal aortic surgeryIntensive care unitAortic surgeryDialysis dependencePostoperative mortalityVentilator daysRenal insufficiencyLower incidenceElective infrarenal aortic surgeryPostoperative intensive care unitElective aortic surgeryPreoperative renal insufficiencySerum creatinine elevationSuprarenal cross clampingRenal artery stenosisLower mortality rateICU stayPreoperative creatinineCreatinine elevationCreatinine clearanceRenal functionConsecutive patientsCross clampingArtery stenosisCare unit