2012
Olive Oil Polyphenols Differentially Inhibit Smooth Muscle Cell Proliferation through a G1/S Cell Cycle Block Regulated by ERK1/2
Abe R, Beckett J, Abe R, Nixon A, Rochier A, Yamashita N, Sumpio B. Olive Oil Polyphenols Differentially Inhibit Smooth Muscle Cell Proliferation through a G1/S Cell Cycle Block Regulated by ERK1/2. International Journal Of Angiology 2012, 21: 069-076. PMID: 23730132, PMCID: PMC3444010, DOI: 10.1055/s-0032-1315630.Peer-Reviewed Original ResearchSmooth muscle cell proliferationMuscle cell proliferationCell cycle blockOlive oil polyphenolsCell cycle analysisDay 1SMC proliferationG1/S cell cycle blockCycle blockOil polyphenolsRisk of atherosclerosisCell proliferationOLE groupControl groupFlow cytometryVascular SMCsWestern blottingDays of exposureS phaseCycle analysisERK1/2 activationNumber of cellsCell populationsOlive oilG1 phase
2011
Olive Oil Polyphenol Oleuropein Inhibits Smooth Muscle Cell Proliferation
Abe R, Beckett J, Abe R, Nixon A, Rochier A, Yamashita N, Sumpio B. Olive Oil Polyphenol Oleuropein Inhibits Smooth Muscle Cell Proliferation. European Journal Of Vascular And Endovascular Surgery 2011, 41: 814-820. PMID: 21333557, DOI: 10.1016/j.ejvs.2010.12.021.Peer-Reviewed Original ResearchConceptsSmooth muscle cell proliferationMuscle cell proliferationCell cycle analysisSMC proliferationCell proliferationInhibits Smooth Muscle Cell ProliferationVascular smooth muscle cell proliferationCoronary artery diseaseNon-treated groupExtracellular signal-regulated kinase 1/2 activationCardiovascular mortalityArtery diseaseKinase 1/2 activationCell cycle blockG1-S phaseMediterranean dietDay 1Oleuropein treatmentGrowth of SMCsG1 phase regulatorsFlow cytometryVascular SMCsPresence of oleuropeinBeneficial effectsCycle analysis
2002
Inhibition of vascular smooth muscle cell proliferation with red wine and red wine polyphenols
Araim O, a J, Waterhouse AL, Sumpio BE. Inhibition of vascular smooth muscle cell proliferation with red wine and red wine polyphenols. Journal Of Vascular Surgery 2002, 35: 1226-1232. PMID: 12042735, DOI: 10.1067/mva.2002.124358.Peer-Reviewed Original ResearchConceptsRed wine polyphenol extractVascular SMC proliferationRed wine polyphenolsVascular smooth muscle cell proliferationSmooth muscle cell proliferationMuscle cell proliferationSMC proliferationAtherosclerotic diseaseBeneficial effectsWine polyphenolsVascular SMCsTrypan blue exclusion studiesDealcoholized red wineRed wine consumptionCell proliferationPolyphenol extractDose-dependent fashionInhibits SMC proliferationPotential beneficial effectsObserved beneficial effectsBovine aortic SMCDehydrogenase cytotoxicityAortic SMCsInhibitory effectRed wine