1987
Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity.
Sumpio B, Baue A, Chaudry I. Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity. Surgery 1987, 101: 315-22. PMID: 2950608.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateRenal perfusate flowTubular absorptionPerfusate flowUrine outputImmunosuppressive agentsVerapamil pretreatmentClearance periodMicrograms/ATP-MgCl2 treatmentControl clearance periodsUse of cyclosporineCombination of verapamilSerious side effectsTissue ATP levelsEffects of adenosineCyA treatmentCyA nephrotoxicityCyclosporine nephrotoxicityVerapamil treatmentTubular functionRenal flowNephrotoxic potentialFiltration rateATP-MgCl2
1985
Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 438-445. PMID: 3872964, DOI: 10.1016/0022-4804(85)90059-9.Peer-Reviewed Original ResearchConceptsDrug-induced nephrotoxicityGlomerular filtration rateRenal perfusate flowATP-MgCl2Filtration ratePerfusate flowMM ATP-MgCl2Prevention of nephrotoxicityGentamicin-induced nephrotoxicitySignificant clinical problemNon-pulsatile perfusionIsolated kidney preparationMin of perfusionHr of perfusionDose-dependent mannerTubular absorptionUrinary flowGentamicin treatmentProtein reabsorptionClinical problemNephrotoxicityPerfusate concentrationFractional clearanceClearance periodSodium absorption
1982
Kinetics, competition, and selectivity of tubular absorption of proteins
Sumpio BE, Maack T. Kinetics, competition, and selectivity of tubular absorption of proteins. American Journal Of Physiology 1982, 243: f379-f392. PMID: 7124951, DOI: 10.1152/ajprenal.1982.243.4.f379.Peer-Reviewed Original ResearchConceptsBeta 2MTubular absorptionHuman growth hormoneLow perfusate calcium concentrationsPerfusate calcium concentrationMorphologic damageTubular epitheliumProximal tubulesGrowth hormoneRat kidneyCationic proteinCalcium concentrationSaturable processSaturating loadSelective effectLuminal wallLow apparent affinityTubulesImportant determinantReversible mannerApparent affinityMicrovilliProteinKidney