2004
17β-Estradiol Exposure Leads to Activation of ERK and p38 but Not JNK in Vascular Endothelial Cells
Knox R, Chen E, Wang X, Jeffries B, Yamaguchi M, Kim S, Sumpio B. 17β-Estradiol Exposure Leads to Activation of ERK and p38 but Not JNK in Vascular Endothelial Cells. International Journal Of Angiology 2004, 13: 67-70. DOI: 10.1007/s00547-004-1068-9.Peer-Reviewed Original ResearchEndothelial nitric oxide synthaseVascular endothelial cellsBovine aortic endothelial cellsEndothelial cellsNitric oxideNitric oxide synthaseEndothelial NO productionAnti-phosphospecific antibodiesEndothelial cell productionAortic endothelial cellsRapid activationAtheroprotective effectsActivation of ERKOxide synthaseFetal calf serumE2 exposureNO productionENOS activationActivity of JNKEstrogenBiphasic patternP38 phosphorylationMonophasic mannerTotal ERKERK phosphorylation17β-Estradiol exposure leads to activation of ERK and p38 but not JNK in vascular endothelial cells
Knox R, Chen E, Wang X, Jeffries B, Yamaguchi M, Kim S, Sumpio B. 17β-Estradiol exposure leads to activation of ERK and p38 but not JNK in vascular endothelial cells. International Journal Of Angiology 2004, 67-70. DOI: 10.1055/s-0031-1276450.Peer-Reviewed Original ResearchEndothelial nitric oxide synthaseVascular endothelial cellsBovine aortic endothelial cellsEndothelial cellsNitric oxideNitric oxide synthaseEndothelial NO productionAnti-phosphospecific antibodiesEndothelial cell productionAortic endothelial cellsRapid activationAtheroprotective effectsActivation of ERKOxide synthaseFetal calf serumE2 exposureNO productionENOS activationActivity of JNKEstrogenBiphasic patternP38 phosphorylationMonophasic mannerTotal ERKERK phosphorylation
1999
Phosphatidylinositol-3 Kinase Dependent MAP Kinase Activation via p21ras in Endothelial Cells Exposed to Cyclic Strain
Ikeda M, Kito H, Sumpio B. Phosphatidylinositol-3 Kinase Dependent MAP Kinase Activation via p21ras in Endothelial Cells Exposed to Cyclic Strain. Biochemical And Biophysical Research Communications 1999, 257: 668-671. PMID: 10208841, DOI: 10.1006/bbrc.1999.0532.Peer-Reviewed Original ResearchMeSH KeywordsAndrostadienesAnimalsAortaCalcium-Calmodulin-Dependent Protein KinasesCattleCells, CulturedChromonesEndothelium, VascularEnzyme ActivationGuanosine TriphosphateHemodynamicsMorpholinesOncogene Protein p21(ras)Phosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPhosphorylationSignal TransductionStress, MechanicalTime FactorsWortmanninConceptsERK1/2 activationPhosphatidylinositol-3 kinase inhibitorMAP kinase activationExtracellular signal-regulated protein kinases 1Endothelial cellsMechanical stretchKinase inhibitorsERK1/2 phosphorylationEffect of wortmanninPossible involvementHemodynamic forcesProtein kinase 1ActivationKinase 1Upstream pathwaysRapid activationKinase activationSignal transduction pathwaysP21ras activationLY294002ERK1 activationERK2 activation