Thrombospondin-1 induces matrix metalloproteinase-2 activation in vascular smooth muscle cells1 1Competition of interest: none.
Lee T, Esemuede N, Sumpio BE, Gahtan V. Thrombospondin-1 induces matrix metalloproteinase-2 activation in vascular smooth muscle cells1 1Competition of interest: none. Journal Of Vascular Surgery 2003, 38: 147-154. PMID: 12844104, DOI: 10.1016/s0741-5214(02)75468-2.Peer-Reviewed Original ResearchConceptsThrombospondin-1TSP-1-induced VSMC migrationVSMC migrationCell migrationMatrix metalloproteinase-2MMP2 activationMatrix barrierSerum-free mediumNorthern blot analysisVascular smooth muscle cell migrationCellular processesExtracellular matrix glycoproteinMMP2 activityPosttranslational mechanismsMatrix metalloproteinase-2 activationMetalloproteinase-2 activationSmooth muscle cell migrationMuscle cell migrationInvasion assaysStrong binding activityBinding activityECM degradationMatrix glycoproteinRNA expressionBlot analysis