Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity.
Sumpio B, Baue A, Chaudry I. Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity. Surgery 1987, 101: 315-22. PMID: 2950608.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateRenal perfusate flowTubular absorptionPerfusate flowUrine outputImmunosuppressive agentsVerapamil pretreatmentClearance periodMicrograms/ATP-MgCl2 treatmentControl clearance periodsUse of cyclosporineCombination of verapamilSerious side effectsTissue ATP levelsEffects of adenosineCyA treatmentCyA nephrotoxicityCyclosporine nephrotoxicityVerapamil treatmentTubular functionRenal flowNephrotoxic potentialFiltration rateATP-MgCl2T-Lymphocyte Subsets in Renal Allograft Recipients Treated with Cyclosporine and Azathioprine
SUMPIO B, DWYER J, FLYE M. T-Lymphocyte Subsets in Renal Allograft Recipients Treated with Cyclosporine and Azathioprine. Annals Of Surgery 1987, 205: 49-53. PMID: 3541801, PMCID: PMC1492880, DOI: 10.1097/00000658-198701000-00009.Peer-Reviewed Original ResearchConceptsT4/T8 ratioRenal allograft recipientsT cell subsetsAntithymocyte globulinAllograft recipientsT8 ratioImmunosuppressive agentsPlasma levelsT lymphocytesNormal T4/T8 ratioDifferent immunosuppression protocolsT lymphocyte subsetsT4/T8Monoclonal antibody OKT3Cytomegalovirus titersImmunosuppression protocolsT4 subsetAntibody OKT3CyclosporinePatientsAzathioprineOnly azathioprineSelective ablationPrednisoneOKT3