2014
Characterization of Extracellular Signal-Regulated Kinase 5 Levels in Human Umbilical Vein Endothelial Cells Exposed to Disturbed and Uniform Flow
Shalaby S, Chitragari G, Sumpio BJ, Sumpio BE. Characterization of Extracellular Signal-Regulated Kinase 5 Levels in Human Umbilical Vein Endothelial Cells Exposed to Disturbed and Uniform Flow. International Journal Of Angiology 2014, 23: 187-192. PMID: 25317031, PMCID: PMC4169104, DOI: 10.1055/s-0034-1378136.Peer-Reviewed Original Research
2008
Synergistic Effect of Cool/Thaw Cycles on Vascular Cells in an In Vitro Model of Cryoplasty
Yiu WK, Cheng SW, Sumpio BE. Synergistic Effect of Cool/Thaw Cycles on Vascular Cells in an In Vitro Model of Cryoplasty. Journal Of Vascular And Interventional Radiology 2008, 19: 925-930. PMID: 18503909, DOI: 10.1016/j.jvir.2008.02.007.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsAkt activationEndothelial cellsApoptotic smooth muscle cellsActivation of AktBovine aortic smooth muscle cellsAortic smooth muscle cellsSurvival responseDeoxynucleotidyl transferase-mediated dUTP nick end labelingFetal bovine serumTerminal deoxynucleotidyl transferase-mediated dUTP nick end labelingTransferase-mediated dUTP nick end labelingImmunoblot analysisDUTP nick end labelingHigher apoptotic rateVascular cells
2005
Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells
Akasaka K, Akasaka N, Di Luozzo G, Sasajima T, Sumpio BE. Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells. Journal Of Vascular Surgery 2005, 41: 517-522. PMID: 15838488, DOI: 10.1016/j.jvs.2004.12.043.Peer-Reviewed Original ResearchConceptsEffect of homocysteineMigration of SMCsLevels of homocysteineProgressive intimal thickeningAortic smooth muscle cellsSmooth muscle cell migrationBovine aortic smooth muscle cellsPotential therapeutic implicationsSmooth muscle cellsP38 activationExposure of SMCMuscle cell migrationSMC chemotaxisRisk factorsSelective blockadeIntimal thickeningTherapeutic implicationsP38-dependent pathwaySMC proliferationBoyden chamberChemotactic potentialMuscle cellsHomocysteineFetal bovine serumP38 inhibitor
1996
Protein phosphatase 2A in stretch‐induced endothelial cell proliferation
Murata K, Mills I, Sumpio B. Protein phosphatase 2A in stretch‐induced endothelial cell proliferation. Journal Of Cellular Biochemistry 1996, 63: 311-319. PMID: 8913882, DOI: 10.1002/(sici)1097-4644(19961201)63:3<311::aid-jcb6>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsProtein phosphatase 2APhosphatase 2AProtein phosphatase 2A activityProtein phosphatase 1Phosphatase 2A activityProtein kinase CPhosphatase 1Bovine aortic endothelial cellsOkadaic acidGrowth suppressorEndothelial cellsKinase CEndothelial cell proliferationCell growthFetal bovine serumCellular proliferationAortic endothelial cellsCell proliferationCyclic strainBovine serumKey mechanismProliferationCellsStrainsSuppressor
1992
Isolation and characterization of rabbit cardiac endothelial cells: Response to cyclic strain and growth factors in vitro
Widmann M, Letsou G, Phan S, Baldwin J, Sumpio B. Isolation and characterization of rabbit cardiac endothelial cells: Response to cyclic strain and growth factors in vitro. Journal Of Surgical Research 1992, 53: 331-334. PMID: 1405613, DOI: 10.1016/0022-4804(92)90057-7.Peer-Reviewed Original ResearchConceptsRetina-derived growth factorCardiac endothelial cellsEndothelial cellsGrowth factorPure endothelial cellsEC proliferationProliferative responseExogenous growth factorsTrophic effectsRabbit heartsAcetylated LDLCardiac endotheliumCollagenase digestionFetal bovine serumPulsatile strainSignificant increaseBovine serumProliferationEC morphologyCellsRegimenResponseLDLEndotheliumFactors