1987
Mitochondrial Respiratory and Calcium Studies
SUMPIO B, BAUE A, CHAUDRY I. Mitochondrial Respiratory and Calcium Studies. Annals Of Surgery 1987, 206: 655-660. PMID: 3499878, PMCID: PMC1493310, DOI: 10.1097/00000658-198711000-00017.Peer-Reviewed Original ResearchConceptsRespiratory control ratioVerapamil pretreatmentTotal tissue Ca2Tissue ATP levelsCyA-induced nephrotoxicityCyA treatmentPharmacologic regimenRenal functionMitochondrial respiratory functionSimultaneous administrationCalcium studiesRespiratory functionKrebs bufferCortical mitochondriaMumol/Tissue Ca2Rat kidneyADP/O ratioCyANephrotoxicityATP levelsControl ratioVerapamilMitochondrial respiratoryCa2
1986
Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney
Sumpio B, Hull M, Bauer A, Chaudry I. Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney. Biochimica Et Biophysica Acta 1986, 862: 303-308. PMID: 3778894, DOI: 10.1016/0005-2736(86)90232-4.Peer-Reviewed Original ResearchConceptsATP-MgCl2 administrationColloid oncotic pressureIntracellular ATPATP-MgCl2Exogenous administrationIntracellular ATP levelsRat kidneyOncotic pressureAdministrationTotal intracellular ATPPerfusate solutionKidneyIntracellular accumulationATP levelsAdenine nucleotidesSignificant accumulationATPPerfusate
1985
Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance
Sumpio B, Chaudry I, Baue A. Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance. JAMA Surgery 1985, 120: 233-240. PMID: 3872113, DOI: 10.1001/archsurg.1985.01390260091013.Peer-Reviewed Original ResearchConceptsIntracellular acidosisPerfusate flowATP levelsAdenosine triphosphate-magnesium chlorideRenal ATP levelsMinutes of reperfusionTissue ATP levelsEffects of ischemiaAdenosine triphosphateML/minPostischemic administrationReperfusion injuryRenal ischemiaWarm ischemiaATP-MgCl2ReperfusionIschemiaInorganic phosphate peakIntracellular adenosine triphosphatePi peakRat kidneyAcidosisATP depletionMinutesMagnetic resonance