1998
Antiproliferative effect of elevated glucose in human microvascular endothelial cells
Kamal K, Du W, Mills I, Sumpio B. Antiproliferative effect of elevated glucose in human microvascular endothelial cells. Journal Of Cellular Biochemistry 1998, 71: 491-501. PMID: 9827695, DOI: 10.1002/(sici)1097-4644(19981215)71:4<491::aid-jcb4>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsMicrovascular endothelial cellsElevated glucoseHMEC-1Endothelial cellsAntiproliferative effectsDiabetic microangiopathyDiabetic foot ulcerationHuman dermal microvascular endothelial cellsCyclic AMP accumulationMicrovascular endothelial cell lineDermal microvascular endothelial cellsHuman microvascular endothelial cellsImmortalized human dermal microvascular endothelial cell lineHigh D-glucoseDeleterious effectsHuman dermal microvascular endothelial cell linePrimary cultured cellsEndothelial cell lineFoot ulcerationHMEC-1 proliferationProliferative responseAMP accumulationPathological complicationsMolecular pathophysiologyRp-cAMPS
1997
Strain activation of bovine aortic smooth muscle cell proliferation and alignment: Study of strain dependency and the role of protein kinase A and C signaling pathways
Mills I, Cohen C, Kamal K, Li G, Shin T, Du W, Sumpio B. Strain activation of bovine aortic smooth muscle cell proliferation and alignment: Study of strain dependency and the role of protein kinase A and C signaling pathways. Journal Of Cellular Physiology 1997, 170: 228-234. PMID: 9066778, DOI: 10.1002/(sici)1097-4652(199703)170:3<228::aid-jcp2>3.0.co;2-q.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 2Adenylyl CyclasesAnimalsAortaCattleCell DivisionCells, CulturedCyclic AMPCyclic AMP Response Element-Binding ProteinCyclic AMP-Dependent Protein KinasesEndothelium, VascularLeucine ZippersMuscle, Smooth, VascularProtein Kinase CSignal TransductionStress, MechanicalTranscription FactorsConceptsBovine aortic SMCSMC proliferationCAMP response elementAortic SMCsAC/cAMP/PKAAortic smooth muscle cell proliferationSmooth muscle cell proliferationProtein levelsCyclic AMP accumulationMuscle cell proliferationSmooth muscle cell phenotypeExposure of SMCAdenylate cyclase activityMuscle cell phenotypeAMP accumulationInhibition of PKACAMP/PKACyclic AMP pathwayMultifactorial natureProtein kinase C activityCyclase activityProtein kinase A (PKA) activityLack of involvementEnhanced proliferationCell proliferation