2019
Impact of modulation of the α7 nicotinic acetylcholine receptor on nicotine reward in the mouse conditioned place preference test
Jackson A, Alkhlaif Y, Papke RL, Brunzell DH, Damaj MI. Impact of modulation of the α7 nicotinic acetylcholine receptor on nicotine reward in the mouse conditioned place preference test. Psychopharmacology 2019, 236: 3593-3599. PMID: 31302720, PMCID: PMC6895411, DOI: 10.1007/s00213-019-05331-y.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsConditioning, ClassicalDose-Response Relationship, DrugMaleMiceMice, Inbred ICRNicotineNicotinic AgonistsRewardConceptsPositive allosteric modulatorsΑ7 nicotinic acetylcholine receptorNicotine rewardNicotine CPPNicotinic acetylcholine receptorsΑ7 nAChRsAgonist PNU282987Acetylcholine receptorsPlace preference testMorphine CPPPharmacological modulationPharmacological agentsCPP paradigmPlace preferenceAllosteric modulatorsPNU282987MethodsThe effectsΑ7Beneficial effectsMiceSilent agonistPNU120596ObjectivesThis studyNS1738NS6740
2018
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice
Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D'Aniello E, Giordano C, Ignatowska-Jankowska BM, Mustafa MA, Guida F, Petrie GN, Parker L, Smoum R, Sim-Selley L, Maione S, Lichtman AH, Damaj MI, Di Marzo V, Mechoulam R. N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice. Neuropharmacology 2018, 148: 320-331. PMID: 29567093, PMCID: PMC6408981, DOI: 10.1016/j.neuropharm.2018.03.020.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryNicotine-dependent miceNicotine addictionNicotine rewardInsular cortexWithdrawal responseNicotine CPPExperimental traumatic brain injuryPeroxisome proliferator-activated receptor alphaProliferator-activated receptor alphaPlace preference paradigmN-oleoyl glycineTobacco smokingMorphine CPPCigarette smokersIntraperitoneal administrationAntagonist GW6471Brain damageBrain injuryOlGlySystemic administrationRewarding effectsReceptor alphaMicePreference paradigm