2018
The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome
Abou Ziki M, Mani A. The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome. Nutrition Research 2018, 70: 18-25. PMID: 30049588, PMCID: PMC6320319, DOI: 10.1016/j.nutres.2018.06.009.Peer-Reviewed Original ResearchConceptsMetabolic syndromeLow density lipoprotein clearanceVascular smooth muscle proliferationEnd-organ complicationsCanonical WntSmooth muscle proliferationLow-density lipoproteinDe novo lipogenesisInsulin receptor expressionTranscription factor 7Growth factor βRas homolog gene family member AExtracellular matrix depositionCardiometabolic abnormalitiesLiver inflammationFamily member AInsulin resistanceLipoprotein clearanceLiver fatHepatic fibrosisSevere manifestationsLDL receptor-related protein 6Receptor expressionCardiovascular diseaseMuscle proliferation
2015
The Protective Effect of Transcription Factor 7‐Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta‐Analysis
Wang S, Song K, Srivastava R, Fathzadeh M, Li N, Mani A. The Protective Effect of Transcription Factor 7‐Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta‐Analysis. Journal Of Diabetes Research 2015, 2015: 468627. PMID: 26576435, PMCID: PMC4631899, DOI: 10.1155/2015/468627.Peer-Reviewed Original ResearchConceptsType 2 diabetesTranscription factor 7Rs7903146 variantNondiabetic subjectsMinor alleleHeterozygote comparison modelHDL-C levelsLower plasma triglyceride levelsTCF7L2 rs7903146 polymorphismFactor 7Plasma lipid levelsPlasma triglyceride levelsVariant rs7903146Metabolic syndromeRs7903146 polymorphismPlasma lipidsTG levelsTriglyceride levelsPlasma triglyceridesLipid levelsProtective effectLower riskElectronic databasesType 2Meta-Analysis