2012
Chapter 58 Complications of radiotherapy to the central nervous system
Omuro AM, Martin-Duverneuil N, Delattre JY. Chapter 58 Complications of radiotherapy to the central nervous system. Handbook Of Clinical Neurology 2012, 105: 887-901. PMID: 22230540, DOI: 10.1016/b978-0-444-53502-3.00030-6.Peer-Reviewed Original Research
2011
Cognitive functions in primary CNS lymphoma after single or combined modality regimens
Correa DD, Shi W, Abrey LE, Deangelis LM, Omuro AM, Deutsch MB, Thaler HT. Cognitive functions in primary CNS lymphoma after single or combined modality regimens. Neuro-Oncology 2011, 14: 101-108. PMID: 22013168, PMCID: PMC3245999, DOI: 10.1093/neuonc/nor186.Peer-Reviewed Original ResearchConceptsWhole brain radiotherapyPrimary CNS lymphomaQuality of lifeHD-MTXWhite matter diseaseModality regimenCNS lymphomaHigh-dose methotrexate-based chemotherapyCognitive impairmentExtensive white matter diseaseMethotrexate-based chemotherapySubset of patientsBaseline neuropsychological evaluationBrain radiotherapyDisease remissionModality regimensMost cognitive domainsStandard treatmentTreatment completionCognitive dysfunctionSufficient severityPatientsNeuropsychological evaluationCognitive functionSubstantial risk
2005
Delayed Neurotoxicity in Primary Central Nervous System Lymphoma
Omuro AM, Ben-Porat LS, Panageas KS, Kim AK, Correa DD, Yahalom J, DeAngelis LM, Abrey LE. Delayed Neurotoxicity in Primary Central Nervous System Lymphoma. JAMA Neurology 2005, 62: 1595-1600. PMID: 16216945, DOI: 10.1001/archneur.62.10.1595.Peer-Reviewed Original ResearchConceptsPrimary central nervous lymphomaPathophysiologic mechanismsPrimary central nervous system lymphomaMemorial Sloan-Kettering Cancer CenterTreatment-related toxic effectsCentral nervous system lymphomaDiffuse white matter diseaseAvailable autopsy dataProgressive subcortical dementiaMental status changesNervous system lymphomaDepartment of NeurologyWhite matter damagePotential risk factorsWhite matter diseaseFrontal-subcortical circuitsMicrovascular alterationsNeurologic deteriorationCumulative incidenceClinical courseImproved survivalRetrospective reviewSystem lymphomaClinical findingsSubcortical dementia