2013
Implications of Myocardial Reperfusion on Survival in Women Versus Men With Acute Myocardial Infarction Undergoing Primary Coronary Intervention
Meller SM, Lansky AJ, Costa RA, Soffler M, Costantini CO, Brodie BR, Cox DA, Stuckey TD, Fahy M, Grines CL, Stone GW. Implications of Myocardial Reperfusion on Survival in Women Versus Men With Acute Myocardial Infarction Undergoing Primary Coronary Intervention. The American Journal Of Cardiology 2013, 112: 1087-1092. PMID: 23827398, DOI: 10.1016/j.amjcard.2013.05.052.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionMyocardial blush gradeAcute myocardial infarctionIndependent predictorsMyocardial perfusionPrimary angioplastyCoronary interventionMyocardial infarctionMyocardial Infarction 3 flowEnhanced survival benefitWomen Versus MenPrimary coronary interventionLong-term mortalityPercutaneous coronary interventionFinal ThrombolysisMBG 2/3Blush gradeLate mortalitySurvival benefitMyocardial reperfusionMyocardial salvageGender-specific responsesLate survivalInterventional strategiesMortality rate
2011
Relationship between angiographic dynamic and densitometric assessment of myocardial reperfusion and survival in patients with acute myocardial infarction treated with primary percutaneous coronary intervention: The Harmonizing Outcomes with Revascularization and Stents in AMI (HORIZONS-AMI) trial
Brener SJ, Cristea E, Mehran R, Dressler O, Lansky AJ, Stone GW. Relationship between angiographic dynamic and densitometric assessment of myocardial reperfusion and survival in patients with acute myocardial infarction treated with primary percutaneous coronary intervention: The Harmonizing Outcomes with Revascularization and Stents in AMI (HORIZONS-AMI) trial. American Heart Journal 2011, 162: 1044-1051. PMID: 22137078, DOI: 10.1016/j.ahj.2011.08.022.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPercutaneous coronary interventionCoronary interventionIndependent predictorsMyocardial infarctionMyocardial perfusionHORIZONS-AMI studyEarly clinical outcomesLong-term mortalityElevation myocardial infarctionAcute myocardial infarctionHarmonizing OutcomesLate mortalityAMI trialEpicardial flowMyocardial reperfusionClinical outcomesGrade 2/3Multivariable analysisLate survivalPatientsMortalityTime pointsDensitometric assessmentImpact of Bleeding on Mortality After Percutaneous Coronary Intervention Results From a Patient-Level Pooled Analysis of the REPLACE-2 (Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events), ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy), and HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trials
Mehran R, Pocock S, Nikolsky E, Dangas GD, Clayton T, Claessen BE, Caixeta A, Feit F, Manoukian SV, White H, Bertrand M, Ohman EM, Parise H, Lansky AJ, Lincoff AM, Stone GW. Impact of Bleeding on Mortality After Percutaneous Coronary Intervention Results From a Patient-Level Pooled Analysis of the REPLACE-2 (Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events), ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy), and HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trials. JACC Cardiovascular Interventions 2011, 4: 654-664. PMID: 21700252, DOI: 10.1016/j.jcin.2011.02.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAntithrombinsConfidence IntervalsCoronary Artery DiseaseDrug-Eluting StentsFemaleHealth Status IndicatorsHemorrhageHeparinHirudinsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial ReperfusionPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexRandomized Controlled Trials as TopicRecombinant ProteinsRisk AssessmentRisk FactorsTriageConceptsPercutaneous coronary interventionTIMI major bleedingPatient-level pooled analysisHORIZONS-AMI trialMajor bleedingBlood transfusionSubsequent mortalityRisk scoreHazard ratioIndependent predictorsPooled analysisGlycoprotein IIb/IIIa inhibitorsPercutaneous Coronary Intervention ResultsIIb/IIIa inhibitorsMajor bleeding ratesTIMI major bleedTIMI minor bleedingRespective hazard ratiosArtery bypass graftRisk score groupsHigh-risk groupRisk of patientsIsolated hematomasMajor bleedsLate mortality
2010
Predictive value of C-reactive protein on 30-day and 1-year mortality in acute coronary syndromes: an analysis from the ACUITY trial
Caixeta A, Stone GW, Mehran R, Lee EA, McLaurin BT, Cox DA, Bertrand ME, Lincoff AM, Moses JW, White HD, Ohman EM, Palmerini T, Syros G, Kittas C, Fahy M, Hooper WC, Lansky AJ, Dangas GD. Predictive value of C-reactive protein on 30-day and 1-year mortality in acute coronary syndromes: an analysis from the ACUITY trial. Journal Of Thrombosis And Thrombolysis 2010, 31: 154-164. PMID: 20953817, DOI: 10.1007/s11239-010-0516-y.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeC-reactive proteinTroponin-positive patientsBaseline CRP levelsCRP levelsACUITY trialCoronary syndromeHigh-risk acute coronary syndromesQuartiles of CRPEarly invasive treatment strategyRelationship of CRPHigher baseline CRP levelsEarly invasive strategyLong-term mortalityPowerful independent predictorEarly invasive treatmentTroponin-negative patientsInvasive treatment strategyLate mortalityPositive patientsIndependent predictorsClinical outcomesCRP valuesHighest quartileMultivariable analysisImpact of Anemia on Clinical Outcomes of Patients With ST-Segment Elevation Myocardial Infarction in Relation to Gender and Adjunctive Antithrombotic Therapy (from the HORIZONS-AMI Trial)
Tsujita K, Nikolsky E, Lansky AJ, Dangas G, Fahy M, Brodie BR, Dudek D, Möckel M, Ochala A, Mehran R, Stone GW. Impact of Anemia on Clinical Outcomes of Patients With ST-Segment Elevation Myocardial Infarction in Relation to Gender and Adjunctive Antithrombotic Therapy (from the HORIZONS-AMI Trial). The American Journal Of Cardiology 2010, 105: 1385-1394. PMID: 20451683, DOI: 10.1016/j.amjcard.2010.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnemiaAngioplasty, Balloon, CoronaryCombined Modality TherapyDrug Therapy, CombinationElectrocardiographyFemaleFibrinolytic AgentsFollow-Up StudiesHeparinHirudinsHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNeoadjuvant TherapyPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexProbabilityProportional Hazards ModelsRecombinant ProteinsRisk AssessmentSex FactorsSurvival AnalysisThrombolytic TherapyTreatment OutcomeConceptsST-elevation myocardial infarctionElevation myocardial infarctionGlycoprotein IIb/IIIa inhibitorsPrimary percutaneous coronary interventionIIb/IIIa inhibitorsBaseline anemiaPercutaneous coronary interventionAdjunctive antithrombotic therapyMajor bleedingMyocardial infarctionAntithrombotic therapyCoronary interventionUnfractionated heparinST-segment elevation myocardial infarctionMultivariate analysisAcute Myocardial Infarction trialImpact of anemiaMyocardial Infarction trialOutcomes of patientsHarmonizing OutcomesCardiac mortalityCause mortalityLate mortalityPrimary PCIClinical outcomesImpact of Delay to Angioplasty in Patients With Acute Coronary Syndromes Undergoing Invasive Management Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Trial
Sorajja P, Gersh BJ, Cox DA, McLaughlin MG, Zimetbaum P, Costantini C, Stuckey T, Tcheng JE, Mehran R, Lansky AJ, Grines CL, Stone GW. Impact of Delay to Angioplasty in Patients With Acute Coronary Syndromes Undergoing Invasive Management Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Trial. Journal Of The American College Of Cardiology 2010, 55: 1416-1424. PMID: 20359590, DOI: 10.1016/j.jacc.2009.11.063.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeCoronary syndromeACUITY trialNSTE-ACSCoronary interventionIndependent predictorsClinical presentationMyocardial infarctionSegment elevation acute coronary syndromesTiming of PCIElevation acute coronary syndromeAdverse ischemic outcomesInvasive management strategyNSTE-ACS patientsHigh-risk featuresSignificant independent predictorsPaucity of dataComposite ischemiaIschemic outcomesUrgent angiographyImpact of delayLate mortalityMultivariable analysisOutcome analysis
2005
Impact of smoking status on outcomes of primary coronary intervention for acute myocardial infarction—The smoker's paradox revisited
Weisz G, Cox DA, Garcia E, Tcheng JE, Griffin JJ, Guagliumi G, Stuckey TD, Rutherford BD, Mehran R, Aymong E, Lansky A, Grines CL, Stone GW. Impact of smoking status on outcomes of primary coronary intervention for acute myocardial infarction—The smoker's paradox revisited. American Heart Journal 2005, 150: 358-364. PMID: 16086943, DOI: 10.1016/j.ahj.2004.01.032.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAnticoagulantsComorbidityCoronary AngiographyFemaleFollow-Up StudiesHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMortalityMyocardial InfarctionPlatelet Aggregation InhibitorsProspective StudiesRecurrenceRiskSmokingSmoking CessationStentsStrokeSurvival AnalysisTreatment OutcomeConceptsAcute myocardial infarctionSmoking statusCurrent smokersSmoker's paradoxCoronary interventionFormer smokersCigarette smokingMyocardial infarctionPrior acute myocardial infarctionPrimary percutaneous coronary interventionPercutaneous transluminal coronary angioplastyTriple-vessel coronary diseaseMechanical reperfusion therapyPrimary coronary interventionProcedural success ratePercutaneous coronary interventionTransluminal coronary angioplastyAge-adjusted riskCurrent smoking statusOccurrence of AMITime of presentationLower mortality rateCADILLAC trialLate mortalityPrimary PCI
2003
Increased CK-MB release is a “trade-off” for optimal stent implantation an intravascular ultrasound study
Iakovou I, Mintz GS, Dangas G, Abizaid A, Mehran R, Kobayashi Y, Lansky AJ, Aymong ED, Nikolsky E, Stone GW, Moses JW, Leon MB. Increased CK-MB release is a “trade-off” for optimal stent implantation an intravascular ultrasound study. Journal Of The American College Of Cardiology 2003, 42: 1900-1905. PMID: 14662249, DOI: 10.1016/j.jacc.2003.06.012.Peer-Reviewed Original ResearchConceptsCK-MB releaseTarget lesion revascularizationOptimal stent implantationStent expansionLesion revascularizationClinical restenosisStent implantationGroup 1Creatine kinase-MB isoenzyme releaseGroup 3Lower mortalityIntravascular ultrasound-guided stentingLower target lesion revascularizationPeak CK-MB valuesMajor adverse cardiac eventsLumen cross-sectional areaAdverse cardiac eventsAggressive stent expansionPercutaneous coronary interventionIntravascular ultrasound studyCK-MB valuesLate mortalityCardiac eventsCoronary interventionConsecutive patients
2002
New-Device Angioplasty in Women: Clinical Outcome and Predictors in a 7,372-Patient Registry
Lansky AJ, Mehran R, Dangas G, Desai K, Costantini-Ortiz C, Cristea E, New G, Negoita M, Stone GW, Leon MB. New-Device Angioplasty in Women: Clinical Outcome and Predictors in a 7,372-Patient Registry. Epidemiology 2002, 13: s46-s51. PMID: 12071484, DOI: 10.1097/00001648-200205001-00010.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsNew device angioplastyClinical outcomesFemale genderHospital mortalityLate mortalityIndependent predictorsMortality rateHospital major adverse cardiac eventsIschemic coronary artery diseaseLong-term clinical outcomesSaphenous vein graft lesionsMultivariable logistic regression analysisDevice-specific outcomesHospital cardiac mortalityLate clinical outcomesAdverse cardiac eventsComorbid risk factorsCongestive heart failureNative coronary arteriesOutcomes of womenVein graft lesionsCoronary artery diseaseReference vessel sizeConventional balloon angioplasty
2001
Clinical outcome following percutaneous coronary interventions in patients with chronic renal failure
Gruberg L, Dangas G, Mehran R, Mintz GS, Kent KM, Pichard AD, Satler LF, Lansky AJ, Stone GW, Leon MB. Clinical outcome following percutaneous coronary interventions in patients with chronic renal failure. Catheterization And Cardiovascular Interventions 2001, 55: 66-72. PMID: 11793497, DOI: 10.1002/ccd.10103.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseChronic renal failurePercutaneous coronary interventionClinical outcomesLate mortalityRenal dysfunctionCoronary interventionRenal failureRenal functionRenal diseaseHigher left ventricular ejection fractionNon-Q-wave myocardial infarctionLeft ventricular ejection fractionAngiographic success rateImpaired renal functionNormal renal functionVentricular ejection fractionHospital mortalityCreatinine clearanceConsecutive patientsDiabetes mellitusEjection fractionIndependent correlatesMyocardial infarctionLarge cohortAre we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results
Hong M, Mehran R, Dangas G, Mintz G, Lansky A, Kent K, Pichard A, Satler L, Stone G, Leon M. Are we making progress with percutaneous saphenous vein graft treatment? A comparison of 1990 to 1994 and 1995 to 1998 results. Journal Of The American College Of Cardiology 2001, 38: 150-154. PMID: 11451265, DOI: 10.1016/s0735-1097(01)01324-9.Peer-Reviewed Original ResearchConceptsLate cardiac eventsSVG lesionsCardiac eventsDistal embolizationStent useSaphenous vein graft angioplastyUnfavorable lesion characteristicsVein graft angioplastyOne-year outcomesProcedural success rateHigh procedural successHigh-risk lesionsGraft angioplastySVG angioplastyLate mortalityRepeat revascularizationBaseline characteristicsProcedural successRisk lesionsFavorable outcomeLesion characteristicsGraft treatmentMultivariate analysisAngioplastyLesions
2000
Long-term clinical events following creatine kinase–myocardial band isoenzyme elevation after successful coronary stenting
Saucedo J, Mehran R, Dangas G, Hong M, Lansky A, Kent K, Satler L, Pichard A, Stone G, Leon M. Long-term clinical events following creatine kinase–myocardial band isoenzyme elevation after successful coronary stenting. Journal Of The American College Of Cardiology 2000, 35: 1134-1141. PMID: 10758952, DOI: 10.1016/s0735-1097(00)00513-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplasty, Balloon, CoronaryBiomarkersCoronary DiseaseCreatine KinaseDisease-Free SurvivalFemaleHumansIncidenceLogistic ModelsMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesPulmonary EdemaRadiographyRecurrenceRisk FactorsSeverity of Illness IndexStentsTreatment OutcomeConceptsCK-MB elevationCreatine kinase-myocardial band isoenzyme (CK-MB) elevationMajor adverse clinical eventsCK-MB riseAdverse clinical eventsCoronary stentingLate mortalityClinical eventsGroup 1Group 3Group 2Long-term clinical importanceLong-term clinical eventsHospital recurrent ischemiaLate clinical outcomesCardiac enzyme elevationEvent-free survivalClinical end pointsHigher late mortalityPercutaneous coronary interventionPercutaneous coronary revascularizationCK-MB levelsNative coronary arteriesSuccessful coronary stentingSuccessful stent implantationAtherosclerotic Plaque Burden and CK-MB Enzyme Elevation After Coronary Interventions
Mehran R, Dangas G, Mintz G, Lansky A, Pichard A, Satler L, Kent K, Stone G, Leon M. Atherosclerotic Plaque Burden and CK-MB Enzyme Elevation After Coronary Interventions. Circulation 2000, 101: 604-610. PMID: 10673251, DOI: 10.1161/01.cir.101.6.604.Peer-Reviewed Original ResearchConceptsCK-MB elevationAtherosclerotic plaque burdenPreintervention intravascular ultrasoundPlaque burdenTimes upper limitIntravascular ultrasoundCoronary interventionSerum creatine kinase MB fractionPlatelet glycoprotein IIb/IIIa inhibitorsGlycoprotein IIb/IIIa inhibitorsReference segmentsFinal minimal lumen diameterLesion site plaque burdenIIb/IIIa inhibitorsCreatine kinase MB fractionAngiographic lesion morphologyDe novo lesionsNative coronary lesionsPercutaneous coronary interventionMinimal lumen diameterDiffuse atherosclerotic diseaseCatheter-based interventionsCross-sectional narrowingAtheroablative techniquesLate mortalityProcedural results and intermediate clinical outcomes after multiple saphenous vein graft stenting
Bhargava B, Kornowski R, Mehran R, Kent K, Hong M, Lansky A, Waksman R, Pichard A, Satler L, Leon M. Procedural results and intermediate clinical outcomes after multiple saphenous vein graft stenting. Journal Of The American College Of Cardiology 2000, 35: 389-397. PMID: 10676686, DOI: 10.1016/s0735-1097(99)00564-1.Peer-Reviewed Original ResearchConceptsMid-term clinical outcomesSVG interventionClinical outcomesProcedural successOverall cardiac event-free survivalCardiac event-free survivalSaphenous vein graft angioplastyNon-Q-wave MIHospital procedural successVein graft angioplastyEvent-free survivalIntermediate clinical outcomesMajor complication rateOverall procedural successSaphenous vein graftsGraft angioplastyLesion revascularizationSimultaneous stentingSVG diseaseSVG groupSVG stentingLate mortalityComplication rateDistal embolizationMI rates
1999
Creatine Kinase-MB Enzyme Elevation Following Successful Saphenous Vein Graft Intervention Is Associated With Late Mortality
Hong M, Mehran R, Dangas G, Mintz G, Lansky A, Pichard A, Kent K, Satler L, Stone G, Leon M. Creatine Kinase-MB Enzyme Elevation Following Successful Saphenous Vein Graft Intervention Is Associated With Late Mortality. Circulation 1999, 100: 2400-2405. PMID: 10595951, DOI: 10.1161/01.cir.100.24.2400.Peer-Reviewed Original ResearchConceptsCK-MB elevationSaphenous vein graft interventionCK-MB riseVein graft interventionLate mortalityGraft interventionClinical eventsCreatine kinase‐MB enzyme elevationPeriprocedural CK-MB elevationNormal CK-MBMajor clinical eventsLate clinical eventsCreatine kinase elevationStrong independent predictorHospital complicationsSVG angioplastySVG interventionSVG lesionsConsecutive patientsDiabetes mellitusEnzyme elevationIndependent predictorsPrognostic significanceCK-MBMultivariate analysis