2022
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Collins M, Ji J, Chung Y, Lympus C, Afriyie-Agyemang Y, Addington J, Goodyear B, Bearden C, Cadenhead K, Mirzakhanian H, Tsuang M, Cornblatt B, Carrión R, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Woods S, Powers A, Anticevic A, Cannon T. Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk. Molecular Psychiatry 2022, 28: 1182-1189. PMID: 36434057, PMCID: PMC10005940, DOI: 10.1038/s41380-022-01870-7.Peer-Reviewed Original ResearchConceptsCHR-NCPercent thickness changeCortical thinningPsychosis onsetHealth controlsProgressive grey matter lossNorth American Prodrome Longitudinal StudyClinical high-risk individualsGray matter lossHigh-risk individualsLongitudinal studyGreater percent decreaseNovel treatment targetsParietal cortical regionsTargeted early interventionsCortical thicknessCortical areasMRI scansCHR individualsTreatment targetsEarly interventionCortical regionsLeft hemisphere regionsROC analysisHC participants
2021
Regression dynamic causal modeling for resting‐state fMRI
Frässle S, Harrison SJ, Heinzle J, Clementz BA, Tamminga CA, Sweeney JA, Gershon ES, Keshavan MS, Pearlson GD, Powers A, Stephan KE. Regression dynamic causal modeling for resting‐state fMRI. Human Brain Mapping 2021, 42: 2159-2180. PMID: 33539625, PMCID: PMC8046067, DOI: 10.1002/hbm.25357.Peer-Reviewed Original Research
2019
Does hallucination perceptual modality impact psychosis risk?
Niles H, Walsh B, Woods S, Powers A. Does hallucination perceptual modality impact psychosis risk? Acta Psychiatrica Scandinavica 2019, 140: 360-370. PMID: 31355420, PMCID: PMC6752971, DOI: 10.1111/acps.13078.Peer-Reviewed Original ResearchConceptsClinical high riskPerceptual abnormalitiesPsychosis riskNon-verbal contentAuditory perceptual abnormalitiesIndividuals ages 12Verbal experienceAuditory experienceCHR individualsThought contentCHR sampleUnusual thought contentPredictive validityAuditory scoresGustatory componentsAge 12Meeting criteriaPsychotic disordersPhenomenological aspectsInterview notesPsychosisConversion riskScoresIndividualsExperience
2017
Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups
Woods SW, Powers AR, Taylor JH, Davidson CA, Johannesen JK, Addington J, Perkins DO, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH. Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups. Schizophrenia Bulletin 2017, 44: 254-263. PMID: 29036402, PMCID: PMC5814797, DOI: 10.1093/schbul/sbx138.Peer-Reviewed Original ResearchConceptsCHR syndromeDiagnostic outcomesCHR subgroupsClinical high-risk syndromeHigh-risk syndromeOnset of psychosisClinical high riskPersistence of anxietyEmergent psychosisCHR patientsRisk syndromeObservational studyCHR casesHigh riskNonpsychotic disordersComorbid disordersComparison subjectsBipolar disorderDiagnostic InterviewSyndromeDSM-IVPatientsPsychosisDiagnostic specificityComparison group